About the Lab
The Wensel Lab research includes the following areas:
- Visual transduction
- G protein pathways and proteins that regulate them in the retina and the brain
- RGS proteins: GAPs for heterotrimeric G proteins
- Biomembranes
- Ocular Proteomics
- Cryo-electron microscopy and tomography
- Gene repair in neurons
- Phosphoinositide signaling
- Super resolution fluorescence microscopy
- Gene engineering in mice and frogs
- TRP Channels
- Primary cilia and retinal ciliopathies
Dosey et al., 2018, Nature Structural and Molecular Biology
Structure of cation channel TRPV2 in open state
Enhanced Serotonin Responses in Dopamine Receptor Mutants
Serotonin responses of dopamine receptors engineered by evolution-guided mutagenesis.
Localization of RGS9-2
Localization of RGS9-2, a regulator of G-protein coupled receptors, in cultured striatal neurons.
Wensel et al., Progress in Retinal and Eye Research, 2016.
3D structure of daughter centriole by cryo-ET
Cryo-electron tomography and sub-tomogram averaging was used to determine 3D structure of a daughter centriole from a mammalian rod sensory cilium.