Positions
- Professor
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Pediatrics
Nutrition
ÌÇÐÄÊÓƵ of Medicine
Houston, Texas, United States
Addresses
- Children's Nutrition Research Center (Lab)
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Room: CNRC-8012
Houston, TX, 77030
United States
Phone: (713) 798-0359
- Children's Nutrition Research Center (Office)
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Room: CNRC-8066
Houston, TX, 77030
United States
Phone: (713) 798-7199
yongx@bcm.edu
Education
- Fellowship at University Of Texas Southwestern Medical School
- Dallas, TX, United States
- PhD from University of Alberta
- 10/2006 - Edmonton, Alberta, Canada
- MSc from Tongji Medical University
- 06/2002 - Wuhan, China
- MD from Tongji Medial University
- 06/1999 - Wuhan, China
Professional Interests
- Brain control of feeding behavior, body weight, and glucose balance
Professional Statement
The goal of my research is to identify the novel neural circuits, neurotransmitters and intra-neuronal signals that are critical for coordinated control of body weight, feeding behavior, and glucose balance. We generate unique mouse models, using Cre-loxP/Flp-frt strategy, with genes of interest manipulated in specific populations of neurons at the time of choice. We use these models, in combination of the modern chemogenetics/optogenetics, electrophysiology and neurotracing approaches, to establish the physiological relevance of specific neural networks in the regulation of energy homeostasis, glucose balance and behaviors.
Ongoing projects in the laboratory include:
(1) To identify the critical ER-expressing neurons and the downstream circuits that mediate estrogenic effects on body weight and glucose balance.
(2) To determine the roles of nuclear receptor co-activators in the hypothalamus in the context of obesity and diabetes.
(3) To reveal the mechanisms by which the central 5-HT neural circuits regulate feeding behavior.
Ongoing projects in the laboratory include:
(1) To identify the critical ER-expressing neurons and the downstream circuits that mediate estrogenic effects on body weight and glucose balance.
(2) To determine the roles of nuclear receptor co-activators in the hypothalamus in the context of obesity and diabetes.
(3) To reveal the mechanisms by which the central 5-HT neural circuits regulate feeding behavior.
Selected Publications
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He Y, Xu P, Wang C, Xia Y, Yu M, Yang Y, Yu K, Cai X, Qu N, Saito K, Wang J, Hyseni I, Robertson M, Piyarathna B, Gao M, Khan SA, Liu F, Chen R, Coarfa C, Zhao Z, Tong Q, Sun Z, Xu Y. " Estrogen receptor-α expressing neurons in the ventrolateral VMH regulate glucose balance. " Nature Communications. 2020 ;
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Cai X, Liu H, Feng B, Yu M, He Y, Liu H, Yang Y, Tu L, Zhang N, Wang L, Yin N, Han J, Yan Z, Wang C, Xu P, Wu Q, Tong Q, He Y, Xu Y. " A D2 to D1 shift in dopaminergic inputs to midbrain 5-HT neurons causes anorexia in mice. " Nat Neuro. 2022 May 25;
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Ye H, Feng B, Wang C, Saito K, Yang Y, Ibrahimi L, Schaul S, Patel N, Saenz L, Luo P, Lai P, Torres V, Kota M, Dixit D, Cai X, Qu N, Hyseni I, Yu K, Jiang Y, Tong Q, Sun Z, Arenkiel BR, He Y, Xu P, Xu Y. " An estrogen-sensitive hypothalamus-midbrain neural circuit controls thermogenesis and physical activity. " Science Advances. 2022 Jan 21;
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Moya-Garzon MD, Wang M, Li VL, ..., Xu Y (co-corresponding), Long JZ.. " A secondary BHB metabolism pathway linked to energy balance.. " Cell (accepted). ;
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