Xinchun Pi

Xinchun Pi, Ph.D.

Associate Professor

(713) 798-5984

Email

xinchun.pi@bcm.edu

Positions

Associate Professor: Medicine-Athero & Lipo
Cardiovascular Research Institute (CVRI)
��Ƶ of Medicine
Houston, TX, US

Member: Dan L Duncan Comprehensive Cancer Center
��Ƶ of Medicine
Houston, Texas, United States

Addresses

Cardiovascular Research Institute (CVRI) (Office): Room: BCMD-507D
Houston, TX, 77030
United States

Education

BS from Wuhan University: 05/1996 - Wuhan, China; Cell and Developmental Biology

MS from Wuhan University: 05/1999 - Wuhan, China; Biochemistry and Biophysics

PhD from University of Rochester: 05/2004 - Rochester, New York, United States; Pharmacology

Post-Doctoral Fellowship at University of North Carolina at Chapel Hill: 05/2008 - Chapel Hill, North Carolina, United States; Cardiovascular Research

Professional Statement

Dr. Pi studies the molecular mechanisms underneath the regulation of endothelial cell functions during vascular development and a variety of pathological conditions such as inflammation, atherosclerosis, peripheral vascular disease, cancer, diabetes and obesity. Her particular focus is to understand the signaling pathways associated with endothelial function that are critical in order to develop treatments for these vascular-associated conditions. Particular attentions are directed toward LRP1 (low density lipoprotein receptor-related protein 1) – and Bmper (Bmp-binding endothelial cell precursor-derived regulator)-dependent signaling pathways. Her work focuses on understanding how endothelial cells respond to ligand, initiate signaling cascades and cellular events such as proliferation, migration, differentiation, angiogenesis, inflammation and atherosclerosis, and change the metabolism to satisfy their needs at different active status.

Websites

Publications listed in PubMed

Selected Publications

Mao H, Angelini A, Li S, Wang G, Li L, Patterson C, Pi X, Xie L.. " " Nat. Metab.. 2023 ; 5 (8) : 1382-1394.
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Angelini A, Pi X, Xie L.. " " STAR Protoc.. 2022 ; 3 (2) : 101392.
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Mao H, Li L, Fan Q, Angelini A, Saha PK, Wu H, Ballantyne CM, Hartig SM, Xie L, Pi X.. " " Nature Communications. 2021 ; 12 (1) : 1927.
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Angelini A, Saha PK, Jain A, Jung SY, Mynatt RL, Pi X, Xie L.. " " Cell Reports. 2021 ; 37 (1) : 109767.
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Mao H, Li L, Fan Q, Angelini A, Saha PK, Coarfa C, Rajapakshe K, Perera D, Cheng J, Wu H, Ballantyne CM, Sun Z, Xie L, Pi X.. " " Nat Commun.. 2021 ; 12 (1) : 5296.
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Fan Q, Mao H, Angelini A, Coarfa C, Robertson MJ, Lagor WR, Wehrens XHT, Martin JF, Pi X, Xie L. " " Circulation.. 2019 ; 140 (5) : 440-442.
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Pi X, Xie L, Patterson C.. " " Circ Res. 2018 ; 123 (4) : 477-494.
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Fan Q, Mao H, Xie L, Pi X. " " Am J Pathol. 2018 ; 89 (1) : 200-213.
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Mao H, Lockyer P, Li L, Ballantyne CM, Patterson C, Xie L, Pi X.. " " Nature Communications. 2017 ; 8 : 14960.
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Mao H, Xie L, Pi X.. " LDL receptor related protein-1 signaling in angiogenesis.. " Front Cardiovasc Med. 2017 ; 4 : 34.
8) Lockyer P, Mao H, Fan Q, Li L, LYu-Lee L, Eissa NT, Patterson C, Xie L, Pi X.. " " Arterioscler Thromb Vasc Biol. 2017 ; 37 (8) : 1524-1535.
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Mao H, Lockyer P, Townley-Tilson WH, Xie L, Pi X.. " " Arterioscler Thromb Vasc Biol. 2016 ; 36 (2) : 350-60.
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Xie L, Pi X, Townley-Tilson WH, Li N, Wehrens XH, Entman ML, Taffet GE, Mishra A, Peng J, Schisler JC, Meissner G, Patterson C.. " PHD2/3-dependent hydroxylation tunes cardiac response to β-adrenergic stress via phospholamban.. " J Clin Invest. 2015 ; 125 (7) : 2759-71.
Xie L, Pi X, Wang Z, Willis MS, Patterson C.. " Depletion of PHD3 protects hearts from injury induced by ischemia/reperfusion and inhibits cardiomyocyte apoptosis induced by oxidative stress.. " J Mol Cell Cardiol. 2015 ; 156-165.
Townley-Tilson WHD, Pi X, Xie L.. " The role of oxygen sensors, hydroxylases, and HIF in cardiac function and disease.. " Oxid Med Cell Longev. 2015 ; 676893.
Dyer L, Lockyer P, Wu Y, Saha A, Cyr C, Moser M, Pi X, Patterson C.. " BMPER Promotes Epithelial-Mesenchymal Transition in the Developing Cardiac Cushions.. " PLoS One. 2015 ; 10 (9) : e0139209.
Cai Y, Nagel DJ, Zhou Q, Li F, Pi X, Knight PA, Yan C.. " Role of cAMP-Phosphodiesterase 1C Signaling in Regulating Growth Factor Receptor Stability, Vascular Smooth Muscle Cell Growth, Migration, and Neointimal Hyperplasia.. " Circ Res. 2015 ; 114 : 304408.
Gomes AV, Rajasekaran NS, Pi X.. " Redox Signaling and the Cardiovascular and Skeletal Muscle System.. " Oxid Med Cell Longev. 2015 ; 849095.
Dyer La, Pi X, Patterson C.. " " Trends Endocrinol Metab. 2014 Sep ; 25 (9) : 472-480.
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Dyer La, Pi X, Patterson C.. " " Developmental Biology. 2014 Nov ; 395 (1) : 111-119.
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Pi X, Xie L, Portbury Al,Kumar S, Lockyer P, Li X, Patterson C. " " Arterioscler Thromb Vasc Biol. 2014 Sep ; 34 (9) : 2023-2032.
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Pi X, Schmitt CE, Xie L, Portbury AL, Wu Y, Lockyer P, Dyer LA, Moser M, Bu G, Flynn EJ 3rd, Jin SW, Patterson C.. " An LRP1-dependent endocytic mechanism governs the signaling output of the bmp system in endothelial cells and in angiogenesis.. " Circ Res. 2012 ; 111 (5) : 564-74.
Pi X, Lockyer P, Dyer L, Schisler J, Carey S, Sweet D, Chen Z, Tzima E, Willis M, Homeister J, Moser M, Patterson C. " Bmper inhibits endothelial inflammation and protects against atherosclerosis.. " Arterioscler Thromb Vasc Biol. 2012 ; 32 (9) : 2214-22.
Xie L1, Pi X, Mishra A, Fong G, Peng J, Patterson C.. " " J Clin Invest. 2012 Aug ; 122 (8) : 2827-2836.
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Pi X, Wu Y, Ferguson JE 3rd, Portbury AL, Patterson C.. " SDF-1alpha stimulates JNK3 activity via eNOS-dependent nitrosylation of MKP7 to enhance endothelial migration.. " Proc Natl Acad Sci USA. 2009 ; 106 (14) : 5675-80.
Pi X, Ren R, Kelley R, Zhang C, Moser M, Bohil A, DiVito M, Cheney RE, Patterson C.. " Sequential roles for Myosin-X in BMP6-dependent filopodial extension, migration, and activation of BMP receptors.. " J Cell Biol. 2007 ; 179 (7) : 1569-82.
Pi X, Garin G, Xie L, Zheng Q, Wei H, Abe J, Yan C, Berk BC.. " BMK1/ERK5 is a novel regulator of angiogenesis by destabilizing hypoxia inducible factor 1alpha.. " Circ Res. 2005 ; 96 (11) : 1145-51.
Pi X, Yan C, Berk BC.. " Big mitogen-activated protein kinase (BMK1)/ERK5 protects endothelial cells from apoptosis.. " Circ Res. 2004 ; 94 (3) : 362-369.

Memberships

American Heart Association: Member (01/2001)

North American Vascular Biology Organization: Member (01/2001)

American Diabetes Association

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