Xi Chen

Xi Chen, Ph.D.

Cullen Duncan McAshan Endowed Chair in Cancer Research

Email

xi.chen@bcm.edu

Positions

Cullen Duncan McAshan Endowed Chair in Cancer Research: Molecular and Cellular Biology
��Ƶ of Medicine
Houston, Texas, United States

Associate Professor and CPRIT Scholar in Cancer Research: Molecular and Cellular Biology
��Ƶ of Medicine
Houston, Texas, United States

Member: Dan L Duncan Comprehensive Cancer Center
��Ƶ of Medicine
Houston, Texas, United States

Education

Postdoctoral Fellowship at Laurie Glimcher Lab, Weill Cornell Medical College: 01/2015 - New York, New York, United States

Postdoctoral Fellowship at Laurie Glimcher Lab, Harvard School of Public Health/Harvard Medical School: 09/2012 - Boston, Massachusetts, United States

PhD from Huck Hui Ng Lab, Genome Institute of Singapore, A*STAR/National University of Singapore: 02/2009 - Singapore, Singapore

Honors & Awards

CPRIT Scholar in Cancer Research: Cancer Prevention Research Institute of Texas (CPRIT) (03/2015 - 02/2019)

Leukemia & Lymphoma Society Career Development Fellow Award: Leukemia & Lymphoma Society (07/2009 - 07/2012)

NIH MERIT Award for Early Stage Investigator: NCI/NIH (07/2018 - 06/2023)

Professional Interests

ER protein quality control; Tumor Microenvironment; Cancer Immunology; Therapy resistance; Stem Cell Maintenance; Unfolded Protein Response; Endoplasmic Reticulum-Associated Degradation;

Professional Statement

The Chen laboratory studies how cancer and its immune microenvironment sense and respond to stresses and therapeutic insults to evade immune surveillance and develop drug resistance. We specialize in ER stress, Unfolded Protein Response (UPR), immunology, cancer biology, biochemistry, transgenic and preclinical animal models. Our research aims to elucidate the significance and mechanisms of stress responses in therapy resistance and anti-tumor immunity, and develop mechanism-based novel therapies to overcome therapy resistance and transform cancer to a manageable chronic disease (Nat Rev Cancer, 2021). Our study published in JCI revealed a critical role of the IRE1a/XBP1 branch of the UPR in mediating chemotherapy resistance and led to the first-in-human clinical trial of IRE1a RNase inhibitor. Our efforts in understanding proteostasis regulation revealed the direct cross-talk between oncogenic signaling and the protein quality control machinery and uncovered the mechanisms that account for the proteostasis rewiring in response to KRAS inhibition, allowing the drug-resistant cells to escape oncogenic KRAS addiction and gain resistance (Science, 2023). Another research area of the Chen laboratory focuses on ER Associated Degradation (ERAD). We recently discovered the crosstalk between ERAD complex and UPR in maintaining proteostasis and niche interactions (Nat Cell Biol, 2020, eLife, 2021).

Selected Publications

Lv X, Lu X, Cao J, Luo Q, Ding Y, Peng F, Pataer A, Lu D, ....Chen Y, Yao W, Chang EC, Catic A, Lin X, Miles G, Huang P, Sun Z, Burt B, Wang H, Wang J, Yao QC, Zhang B, Roth JA, O'Malley BW, Ellis MJ, Rimawi MF, Ying H, Chen X.. " " Science. 2023 Sep 8; 381(6662)
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Xu L, Liu X, Peng F, Zhang W, Zheng L, Ding Y, Gu T, Lv K, Wang J, Ortinau L, Hu T, Shi X, Shi G, Shang G, Sun S, Iwawaki T, Ji Y, Li W, Rosen JM, Zhang XH, Park D, Adoro S, Catic A, Tong W, Qi L, Nakada D, Chen X. " " Nat Cell Biol. 2020 Oct 22; 22 (10) : 1162-1169.
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Zhao N, Cao J ,Xu LY, Tang QZ, Dobrolecki L, Lyu XD, Talukdar M, Lu Y, Wang XR, Wang YF, Liu X, Bu W, Sun Z, Ying HQ, Lin X, Feng XH, Hartig S, Li F, Shen HF, Chen YW, Han L, Zeng QP, Patterson J, Putluri N, Sicheri F, Rosen J, Lewis MT, Chen X. " " J Clin Invest. 2018 ; 128 (4) : 1283-1299.
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Chen X#, Cubillos-Ruiz JR#.. " " Nat Rev Cancer. 2020 Nov 19; (#: Corresponding Author)
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Liu X, Yu J, Xu L, Umphred-Wilson K, Peng F, Ding Y, Barton BM, Lv X, Zhao MY, Sun S, Hong Y, Qi L, Adoro S, Chen X. " " eLife. 2021 Jul 9;
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Chen X, Iliopoulos D, Zhang Q, Tang Q, Greenblatt MB, Hatziapostolou M, Lim E, Tam W, Ni M, Chen Y, Mai J, Shen H, Hu DZ, Adoro Z, Hu B, Song M, Landis MD, Ferrari M, Brown M, Chang JC, Liu XS, Glimcher LH. " " Nature. 2014 ; 508 (7494) : 103-7.
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Chen X, Xu H, Yuan P, Fang F, Huss M, Vega VB, Wong E, Orlov YL, Zhang W, Jiang J, Loh YH, Yeo HC, Yeo ZX, Narang V, Govindarajan KR, Leong B, Shahab A, Ruan Y, Bourque G, Sung WK, Clarke ND, Wei CL, Ng HH. " " Cell. 2008 ; 133 (6) : 1106-17.
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Liu L, Zhao M, Jin X, Ney G, Yang KB, Peng F, Cao J, Iwawaki T, Del Valle J, Chen X, Li Q. " " Nat Cell Biol. 2019 ; 21 (3) : 328-337.
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Zheng ZY, Anurag M, Lei JT, Cao J, Singh P, Peng J, Kennedy H, Nguyen NC, Chen Y, Lavere P, Li J, Du XH, Cakar B, Song W, ......Chen X, Banks KC, Lanman RB, Shafaee MN, Zhang XH, Vasaikar S, Zhang B, Hilsenbeck SG, Li W, Foulds CE, Ellis MJ, Chang EC. " " Cancer Cell. 2020 ; 37 (3) : 387-402..
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Tam WL, Lu H, Buikhuisen J, Soh BS, Lim E, Reinhardt F, Wu ZJ, Krall JA, Bierie B, Guo W, Chen X, Liu XS, Brown M, Lim B, Weinberg RA. " " Cancer Cell. 2013 ; 24 (3) : 347-64.
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Martinon F, Chen X, Lee AH, Glimcher LH. " " Nat Immunol. 2010 ; 11 (5) : 411-8.
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Dong H, Adams NM, Xu Y, Cao J, Allan DSJ, Carlyle JR, Chen X, Sun JC, Glimcher LH. " " Nat Immunol. 2019 ; 20 (7) : 865-878.
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Lazarevic V, Chen X, Shim JH, Hwang ES, Jang E, Bolm AN, Oukka M, Kuchroo VK, Glimcher LH. " " Nat Immunol. 2011 ; 12 (1) : 96-104.
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Chen X, Fang F, Liou YC, Ng HH. " " Stem Cells. 2008 ; 26 (11) : 2759-67.
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Chen X, Vega VB, Ng HH. " " Cold Spring Harb Symp Quant Biol.. 2008 ; 73 : 203-9.
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Wu Q*, Chen X*, Zhang J, Loh YH, Low TY, Zhang W, Zhang W, Sze SK, Lim B, Ng HH. " " J Biol Chem. 2006 ; 281 (34) : 24090-4.
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Zou W, Chen X, Shim JH, Huang Z, Brady N, Hu D, Drapp R, Sigrist K, Glimcher LH, Jones D.. " The E3 ubiquitin ligase Wwp2 regulates craniofacial development through mono-ubiquitylation of Goosecoid. " Nat Cell Biol.. 2011 ; 13 (1) : 59-65.
Chen K, Chen Z, Wu D, Zhang L, Lin X, Su J, Rodriguez B, Xi Y, Xia Z, Chen X, Shi X, Wang Q, Li W.. " " Nat Genet. 2015 Oct ; 47 (10) : 1149-57.
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Loh YH, Wu Q, Chew JL, Vega VB, Zhang W, Chen X, Bourque G, George J, Leong B, Liu J, Wong KY, Sung KW, Lee CW, Zhao XD, Chiu KP, Lipovich L, Kuznetsov VA, Robson P, Stanton LW, Wei CL, Ruan Y, Lim B, Ng HH. " " Nat Genet. 2006 Mar ; 38 (4) : 431-40.
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