Positions
- Instructor
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Medicine
Endocrinology, Diabetes, and Metabolism
ÌÇÐÄÊÓƵ of Medicine
Houston, TX, US
Education
- Postdoctoral Training at ÌÇÐÄÊÓƵ of Medicine
- 12/2019 - Housotn, Texas, United States
- Neuroscience and Metabolism
- Postdoctoral Training at UT MD Anderson Cancer Center
- 11/2014 - Houston, Texas, United States
- Neuropathic Pain and Mood Disorder
- Postdoctoral Training at University of Alabama at Birmingham
- 11/2011 - Birmingham, Alabama, United States
- Mood Disorder
- PhD from University of Shizuoka
- 03/2009 - Shizuoka City, Shizuoka, Japan
- Nutritional Neuroscience
Professional Interests
- Type 2 Diabetes
- Neurocognitive Function
- Environmental Stress and Metabolism disorders
Professional Statement
My research is focused on transcriptional regulation of energy metabolism and neurocognition by endocrine factors, environmental factors, and the circadian clock. I am interested in type 2 diabetes, mood disorders, and neurocognitive impairment.
Selected Publications
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Sungguan Hong, Wenjun Zhou, ..., Mitchell A Lazar, Zheng Sun. " " Nat Med. 2017 Feb ; 23
Pubmed PMID: . -
Wenjun Zhou, Yanlin He, ..., Zheng Sun. " " Nat Neurosci. 2019 Feb ; 22
Pubmed PMID: . -
Kong Y, Zhou W, Sun Z. " " Mol Psychiatry. 2020 Feb ;
Pubmed PMID: . -
Hanneke L D M Willemen, ..., Wenjun Zhou, ..., Niels Eijkelkamp. " " PLoS Biol .. 2018 Feb ; 16
Pubmed PMID: .
Memberships
- American Diabetes Association
- Membership (01/2019)
- Society for Neuroscience
- Membership (04/2010)
Funding
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Regulation of hepatic insulin sensitivity by the hypothalamic circadian clock
#ADA 1-19-PDF-012 - (01/01/2019 - 12/31/2022)
- Grant funding from American Diabetes Association
- Many living organisms on earth have evolved a 24h circadian patterns for sleeping, hunting, and eating, which is entrained by sunlight. Industrialized human society has changed our living environment and led to disruption of circadian rhythm by enhan nighttime light, nighttime activity, shiftwork, and social jetlag. And according to the reports from both clinic and animal model, circadian disruption will induce many metabolic disorders, such as glucose intolerance, and insulin resistance. These are highly related with type2 diabetes. This study will identify the pathological reasons of why, and how circadian disruption will cause the symptoms of type2 diabetes. The central clock structure, called suprachiasmatic nucleus (SCN), locates in the ventral part of hypothalamus, a sub-region of the brain. SCN controls and synchronizes the temporal events which should happen in the different peripheral tissues at different time partially depending on the light received by the retina. For these reasons, SCN is an ideal candidate for studying how circadian disruption changes metabolism. Based on the animal models involved in the current study, the molecular and neuronal targets of SCN, which directly regulate blood glucose level, can be identified. It will potentially refresh the insight of how circadian disruption inferring the glucose metabolism and provide a possible new treatment way.
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