Vishnu Dileep
Assistant Professor, CPRIT Scholar
Positions
- Assistant Professor, CPRIT Scholar
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Huffington Center on Aging
ÌÇÐÄÊÓƵ of Medicine
Houston
- Assistant Professor
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Department of Molecular and Human Genetics
Baylor Colleg of Medicine
- Member
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Dan L Duncan Comprehensive Cancer Center
ÌÇÐÄÊÓƵ of Medicine
Education
- PhD from Florida State University
- Tallahassee, Florida, United States
- Cell and Molecular Biology
- Postdoctoral Training at Massachusetts Institute of Technology
- Cambridge, Massachusetts, United States
Professional Statement
The brain comprises several specialized cell types, some of which, like neurons and oligodendrocytes, can live for decades or as long as the organism itself. This longevity brings the challenge of maintaining their genomic and epigenomic integrity to preserve cellular function. Our lab investigates the organization of the genome and epigenome in brain cells, focusing on the molecular changes that drive brain aging and neurodegeneration.
Our goal is to understand how alterations in the genetic material and its regulation at the molecular level contribute to functional changes in brain aging and age-related neurological diseases at cellular and organismal scales. To achieve this, we investigate the genome from the linear sequence level to the large-scale 3D architecture of the genome, including enhancer-promoter interactions that regulate gene expression. Within this framework, our immediate focus is on how DNA damage accumulation in aging and neurological diseases disrupts genome organization and integrity. By establishing cause-effect relationships in these processes, we aim to uncover new therapeutic targets to mitigate or reverse brain aging and age-related neurological diseases.
Our goal is to understand how alterations in the genetic material and its regulation at the molecular level contribute to functional changes in brain aging and age-related neurological diseases at cellular and organismal scales. To achieve this, we investigate the genome from the linear sequence level to the large-scale 3D architecture of the genome, including enhancer-promoter interactions that regulate gene expression. Within this framework, our immediate focus is on how DNA damage accumulation in aging and neurological diseases disrupts genome organization and integrity. By establishing cause-effect relationships in these processes, we aim to uncover new therapeutic targets to mitigate or reverse brain aging and age-related neurological diseases.
Websites
Selected Publications
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Meharena HS, Marco A, Dileep V, Lockshin ER, Akatsu GY, Mullahoo J, Watson LA, Ko T, Guerin LN, Abdurrob F, Rengarajan S, Papanastasiou M, Jaffe JD, Tsai LH. " " Cell Stem Cell. 2022 ;
Pubmed PMID: . -
Marco A, Meharena HS, Dileep V, Raju RM, Davila-Velderrain J, Zhang AL, Adaikkan C, Young JZ, Gao F, Kellis M, Tsai LH. " " Nat Neurosci.. 2020 ;
Pubmed PMID: . -
Dileep V†* Boix CA*, Mathys H, Marco A, Welch GM, Meharena HS, Loon A, Jeloka R, Peng Z, Bennett DA, Kellis M†, Tsai LH†. " " Cell. 2023 ;
Pubmed PMID: . -
Dileep V, Gilbert DM. " " Nat Commun.. 2018 ;
Pubmed PMID: .
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