Vernon R Sutton

Vernon R Sutton, M.D.

Professor

(832) 822-4292

Email

vrsutton@texaschildrens.org

Positions

Professor: Molecular and Human Genetics
��Ƶ of Medicine
Houston, TX, US

Vice Chair for Graduate Medical Education: Molecular and Human Genetics
��Ƶ of Medicine

Medical Director: Biochemical Genetics
Baylor Genetics

Director: Medical Genetics Residency & Fellowship Programs
��Ƶ of Medicine

Director: Inborn Errors of Metabolism Service
Texas Children's Hospital

Education

BA from Transylvania University, Kentucky: 01/1988 - Lexington, KY, United States

MD from University Of Kentucky College Of Medicine: 01/1992 - Lexington, KY, United States

Residency at Washington University Affiliate Hospitals: 01/1996 - St. Louis, MO, United States; Pediatrics

Clinical Fellowship at ��Ƶ Of Medicine: 01/1999 - Houston, TX, United States; Medical Genetics

Certifications

Clinical Genetics: American Board of Medical Genetics

Clinical Biochemical Genetics: American Board of Medical Genetics

Professional Interests

Osteogenesis imperfecta/brittle bone disease
Achondroplasia
Creatine transporter deficiency
Aicardi syndrome
Goltz syndrome
Inborn Errors of Metabolism
Skeletal dysplasias
Robinow Syndrome
White-Sutton Syndrome

Professional Statement

I have committed myself to advance scientific knowledge and patient care by applying my clinical skills to research questions. I have employed my knowledge and expertise in the diagnosis of genetic syndromes, dysmorphology, genetic mechanisms of disease, inborn errors of metabolism and skeletal dysplasias to answer clinical research questions. I have done this in independent studies of my own design as well as many instances of collaborative research with colleagues engaged in the laboratory investigation of Mendelian diseases.

I have made contributions through gene discovery and defining the phenotypic spectrum of a number of syndromes including Uniparental Disomy for Chromosome 14, Aicardi, Goltz, Ankyloblepharon-Ectodermal Dysplasia Clefting (AEC), Robinow and White-Sutton syndromes. I am the clinical geneticist for the Baylor Center for Genomic Research to Elucidate the Genetics of Rare Disorders (GREGoR) which is an NIH/NHGRI-funded study to discover the genetic basis of Mendelian disorders.

In my role as the Medical Director of the Biochemical Genetics Laboratory at Baylor Genetics, I have overseen the development of large-scale metabolomic profiling for the screening and diagnosis of inborn errors of metabolism, and our laboratory is the first in the world to offer metabolomic profiling on a clinical basis, which has led to both advances in care and new discoveries.

I am co-principal investigator for a multi-site longitudinal study of OI that is funded by the NIH (NCATS, NICHD, NIDCR, NIAMS & NIMH) as part of the Brittle Bone Disorders Consortium of the Rare Disease Clinical Research Network. I am also the clinical team liaison for this project.

Websites

Genetics Clinics

Selected Publications

Snyder MT Divin K Liu N Sun Q Wang Y Luo X Ben-Moshe Y Burrage LC Sutton VR. " " Mol Genet Metab. 2025 Jun ; 145 : 109183.
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Authors: Unger S Ferreira CR Mortier GR Ali H Bertola DR Calder A Cohn DH Cormier-Daire V Girisha KM Hall C Krakow D Makitie O Mundlos S Nishimura G Robertson SP Savarirayan R Sillence D Simon M Sutton VR Warman ML Superti-Furga A. " " Am J Med Genet A. 2023 May ; 191 : 1164-1209.
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Odom JD Sutton VR. " " Clin Chem. 2021 Dec ; 67 : 1606-1617.
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Li Y Tan Z Zhang Y Zhang Z Hu Q (…) Sutton VR Schiff M Feillet F Zhang S Lin C Yang L. " " Science. 2021 Aug ; 373 : 662-673.
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Murali CN Slater B Musaad S Cuthbertson D Nguyen D Turner A Azamian M Tosi L Rauch F Sutton VR Lee B Members of the BBD Consortium Nagamani SCS. " " Clin Genet. 2021 Feb ; 99 : 772-779.
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Liu N, Xiao J, Gijavanekar C, Pappan KL, Glinton KE, Shayota BJ, Kennedy AD, Sun Q, Sutton VR, Elsea SH. " " JAMA Network Open. 2021 Jul ; 4 : e2114155.
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Shayota BJ, Zhang C, Shypailo RJ, Mazzeu JF, Carvalho CMB, Sutton VR. " " Am J Med Genet. 2020 Nov ; 182 : 2632-2640.
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Murali CN, Cuthbertson D, Slater B, Nguyen D, Turner A, (…) Sutton VR, (...) Nagamani SCS. " Pediatric outcomes data collection instrument is a useful patient-reported outcome measure for physical function in children with osteogenesis imperfecta.. " Genet Med.. 2020 ; 22 : 581-5.
Tosi LL, Floor MK, Dollar CM, Gillies AP; Members of the Brittle Bone Disease Consortium, Hart TS, Cuthbertson DD, Sutton VR, Krischer JP. " Assessing disease experience across the life span for individuals with osteogenesis imperfecta: challenges and opportunities for patient-reported outcomes (PROs) measurement: a pilot study.. " Orphanet J Rare Dis.. 2019 ; 14 : 23.
White JJ, Mazzeu JF, Coban-Akdemir Z, Bayram Y, Bahrambeigi V, (...), Sutton VR, Lupski JR, Carvalho CMB. " " Am J Hum Genet.. 2018 Jan ; 102 : 27-43.
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Eldomery MKI, Akdemir ZC, Vögtle FN, Charng WL, Mulica P, (...), Sutton VR. " " Genome Med. 2017 Nov ; 8 : 106.
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Posey JE, Harel T, Liu P, Rosenfeld JA, James RA, (...), Sutton VR, Shaw CA, Plon SE, Yang Y, Lupski JR. " " N Engl J Med.. 2017 Jan ; 376 : 21-31.
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Bostwick B, Fang P, Patel A, Sutton VR. " Phenotypic and molecular characterization of focal dermal hypoplasia in 18 individuals.. " Am J Med Genet C Semin Med Genet.. 2016 ; 172C : 9-20.
Romere C, Duerrschmid C, Bournat J, Constable P, Jain M, Xia F, Saha PK, Del Solar M, Zhu B, York B, Sarkar P, Rendon DA, Gaber MW, LeMaire SA, Coselli JS, Milewicz DM, Sutton VR, Butte NF, Moore DD, Chopra AR. " Asprosin, a Fasting-Induced Glucogenic Protein Hormone.. " Cell. 2016 ; 165 : 566-79.
White J, Beck CR, Harel T, Posey JE, Jhangiani SN, (...), Sutton VR. " " Genome Med. 2016 Jan ; 8 : 3.
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Miller MJ, Kennedy AD, Eckhart AD, Burrage LC, Wulff JE, Miller LA, Milburn MV, Ryals JA, Beaudet AL, Sun Q, Sutton VR, Elsea SH. " " J Inherit Metab Dis. 2015 Apr 15; 38 : 1029-39.
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Chong JX, Buckingham KJ, Jhangiani SN, Boehm C, Sobreira N,..., Sutton VR, Tabor HK, Leal SM, Gunel M, Mane S, Gibbs RA, Boerwinkle E, Hamosh A, Shendure J, Lupski JR, Lifton RP, Valle D, Nickerson DA; Centers for Mendelian Genomics, Bamshad MJ. " " Am J Hum Genet. 2015 Aug 6; 97 (2) : 199-215.
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White J, Mazzeu JF, Hoischen A, Jhangiani SN, ..., Muzny DM, Sutton VR, Gibbs RA; Baylor-Hopkins Center for Mendelian Genomics, Lupski JR, Brunner HG, van Bon BW, Carvalho CM. " " Am J Hum Genet. 2015 Apr 2; 96 : 612-22.
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Atwal PS, Donti TR, Cardon AL, Bacino CA, Sun Q, Emrick L, Reid Sutton V, Elsea SH. " " Mol Genet Metab. 2015 Jun ; 115 : 91-4.
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Patel RM, Nagamani SC, Cuthbertson D, Campeau PM, Krischer JP, Shapiro JR, Steiner RD, Smith PA, Bober MB, Byers PH, Pepin M, Durigova M, Glorieux FH, Rauch F, Lee BH, Hart T, Sutton VR. " " Clin Genet. 2015 Feb ; 87 : 133-40.
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Sutton VR, van Bokhoven H. " " In: Pagon RA, Adam MP, Ardinger HH, Wallace S. 2015 Aug 6;
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Wu N, Ming X, Xiao J, Wu Z, Chen X, Shinawi M, Shen Y,..., Sutton VR, Wang H, Ming Y, Kulkarni S, Zhong TP, Giampietro PF, Dunwoodie SL, Cheung SW, Zhang X, Jin L, Lupski JR, Qiu G, Zhang F. " " N Engl J Med. 2015 Jan 22; 372 (4) : 341-50.
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Sutton VR, Van den Veyver IB. " " In: Pagon RA, Adam MP, Ardinger HH, Wallace S. 2014 Nov 6;
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Miller MJ, Soler-Alfonso CR, Grund JE, Fang P, Sun Q, Elsea SH, Sutton VR. " " Mol Genet Metab. 2014 Jul ; 112 (3) : 205-9.
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Chandler RJ, Tarasenko TN, Cusmano-Ozog K, Sun Q, Sutton VR, Venditti CP, McGuire PJ. " " Gene Ther. 2013 Dec ; 20 (12) : 1188-91.
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Sutton VR, Van den Veyver IB. " " In: Pagon RA, Adam MP, Ardinger HH, Wallace S. 2013 Apr 11;
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Douglas G, Axelrad ME, Brandt ML, Crabtree E, Dietrich JE, French S, Gunn S, Karaviti L, Lopez ME, Macias CG, McCullough LB, Suresh D, Austin E, Reid Sutton V. " " Pediatr Ann.. 2012 ; 41 (4) : e1-7.
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Sutton VR, Chapman KA, Gropman AL, Macleod E, Stagni K, Summar ML, Ueda K, Ah Mew N, Franks J, Island E, Matern D, Peña L, Smith B, Urv T, Venditti C, Chakarapani A. " " Mol. Genet. Metab.. 2012 Jan ; 105 (1) : 26-33.
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Fernandes PH, Wen S, Sutton VR, Ward PA, Van den Veyver IB, Fang P. " " Genet Test Mol Biomarkers. 2010 Oct ; 14 (5) : 709-13.
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Sutton VR, Plunkett K, Dang DX, Lewis RA, Bree AF, Bacino CA. " " Am. J. Med. Genet. A. 2009 Sep ; 149 (9) : 1916-21.
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Eble TN, Sutton VR, Sangi-Haghpeykar H, Wang X, Jin W, Lewis RA, Fang P, Van den Veyver IB. " " Hum. Genet.. 2009 Mar ; 125 (2) : 211-6.
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Wang X, Sutton VR, Eble TN, Lewis RA, Gunaratne P, Patel A, Van den Veyver IB. " " Am. J. Med. Genet. A. 2009 Oct ; 149 (10) : 2113-21.
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Hopkins B, Sutton VR, Lewis RA, Van den Veyver I, Clark G. " " Am. J. Med. Genet. A. 2008 Nov 15; 146 (22) : 2871-8.
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Glasmacher MA, Sutton VR, Hopkins B, Eble T, Lewis RA, Park Parsons D, Van den Veyver IB. " " J. Child Neurol.. 2007 Feb ; 22 (2) : 176-84.
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Cheung SW, Shaw CA, Scott DA, Patel A, Sahoo T, Bacino CA, Pursley A, Li J, Erickson R, Gropman AL, Miller DT, Seashore MR, Summers AM, Stankiewicz P, Chinault AC, Lupski JR, Beaudet AL, Sutton VR. " " Am. J. Med. Genet. A. 2007 Aug 1; 143 (15) : 1679-86.
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Wang X*, Sutton VR*, Peraza O, Yu Z, Rosetta R, Kou YC, Eble TN, Patel A, Thaller C, Fang P, Van den Veyver IB. " " Nat Genet.. 2007 ; 39 (7) : 836-8.
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Memberships

American Society of Human Genetics: Member

American College of Medical Genetics: Fellow

International Skeletal Dysplasia Society: Member

Society of Inherited Metabolic Diseases: Member

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