Tsz-Kwong Man

Tsz-Kwong Man, Ph.D., B.S.

Associate Professor

(832) 824-4682

Email

ctman@texaschildrenshospital.org

Positions

Associate Professor: Pediatrics-Oncology
��Ƶ of Medicine
Houston, TX, US

Member: Dan L Duncan Comprehensive Cancer Center
��Ƶ of Medicine
Houston, Texas, United States

Education

Postdoctoral Training at Washington University: 01/2001 - St. Louis, MO, United States

PhD from University Of Texas Medical School At Houston: 01/1997 - Houston, Texas, United States

BSc from Hong Kong Baptist College: 01/1986 - Hong Kong, Hong Kong

Professional Interests

Research Interests

Professional Statement

Molecular classification of cancer using a systems biology approach. We use a systems biology approach to generate genomic and proteomic profiles from various specimens of cancer patients, such as tumors and plasma. The goal of our laboratory is to integrate these diverse data by various classification algorithms to construct prediction models, which can better predict clinical phenotypes of pediatric cancer, such as drug resistance, metastatic potential, and prognosis. Ultimately, we aim to develop an easy-to-use and minimally invasive blood test that can help to diagnose and prognosticate patients with pediatric cancers, so they can be treated as early and precisely as possible.

Mechanistic study of metastatic determinants. Using a proteomic approach, we have identified p27 (CDKN1B) as a crucial metastatic determinant in pediatric osteosarcoma. We have shown that p27 is frequently mislocalized in the cytoplasm of osteosarcoma cases, and the mislocalization increases the metastatic potential of tumor cells. p27 is a well-known tumor suppressor gene that regulates normal cell cycle progression when it is located in the nucleus, but its oncongenic function when located in the cytoplasm is still largely unknown. It may act as a master switch between tumorigenesis and cancer progression. We use a panel of targeted genomic and proteomic methods to dissect the mechanism of the cytoplasmic p27 in the promotion of metastasis in osteosarcoma and other cancers. Our goal is to test if cytoplasmic p27 can be used as a novel therapeutic target to abolish metastasis in cancer.

Cancer bioinformatics. With the explosion of the genomic data and the decreasing cost of the genomic assays, there is a wealth of genomic data available in various public repositories. These resources provide an unprecedented opportunity for data mining to identify common cancer signatures and mechanisms in various cancers. Understanding these common features of different types of cancer will provide an important clue on how to target cancer in general. Our lab is interested in developing bioinformatic methods and tools that can utilize these resources to answer specific biological or clinical questions that will lead to a better understanding of common cancer phenotypes and the development of novel therapeutic targets.

Websites

Link to VIICTR

Selected Publications

Flores RJ, Li Y, Yu A, Shen J, Rao PH, Lau SS, Vannucci M, Lau CC, Man TK. " " BMC Syst Biol. 2012 ; 6 : 50.
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Egler RA, Li Y, Dang TA, Peters TL, Leung E, Huang S, Russell HV, Liu H, Man TK. " " Proteomics Clin Appl. 2011 Oct ; 5 (41527) : 532-41.
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Li Y, Flores R, Yu A, Okcu MF, Murray J, Chintagumpala M, Hicks J, Lau CC, Man TK. " " Cancer. 2011 Jan 1; 117 (1) : 207-17.
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Li Y, Dang TA, Shen J, Hicks J, Chintagumpala M, Lau CC, Man TK. " " Oncol. Rep.. 2011 Feb ; 25 (2) : 303-14.
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Guo B, Villagran A, Vannucci M, Wang J, Davis C, Man TK, Lau C, Guerra R. " " BMC Res Notes. 2010 ; 3 : 350.
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Cruz-Marcelo A, Guerra R, Vannucci M, Li Y, Lau CC, Man TK. " " Bioinformatics. 2008 Oct 1; 24 (19) : 2129-36.
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Daves MH, Hilsenbeck SG, Lau CC, Man TK. " " BMC Med Genomics. 2011 ; 4 : 56.
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Li Y, Dang TA, Shen J, Perlaky L, Hicks J, Murray J, Meyer W, Chintagumpala M, Lau CC, Man TK. " " Proteomics. 2006 Jun ; 6 (11) : 3426-35.
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Yu L, Baxter PA, Voicu H, Gurusiddappa S, Zhao Y, Adesina A, Man TK, Shu Q, Zhang YJ, Zhao XM, Su JM, Perlaky L, Dauser R, Chintagumpala M, Lau CC, Blaney SM, Rao PH, Leung HC, Li XN. " " Neuro-oncology. 2010 Jun ; 12 (6) : 580-94.
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Wong KK, Tsang YT, Shen J, Cheng RS, Chang YM, Man TK, Lau CC. " " Nucleic Acids Res.. 2004 ; 32 (9) : e69.
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Allen CE, Li L, Peters TL, Leung HC, Yu A, Man TK, Gurusiddappa S, Phillips MT, Hicks MJ, Gaikwad A, Merad M, McClain KL. " " J. Immunol.. 2010 Apr 15; 184 (8) : 4557-67.
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Gu JX, Wei MY, Rao PH, Lau CC, Behl S, Man TK. " " Gene Regul Syst Bio. 2007 ; 1 : 131-6.
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Dang TA, Man TK. " " Curr Pharm Biotechnol. 2007 Apr ; 8 (2) : 83-91.
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Rabin KR, Man TK, Yu A, Folsom MR, Zhao YJ, Rao PH, Plon SE, Naeem RC. " " Pediatr Blood Cancer. 2008 Aug ; 51 (2) : 171-7.
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Cheung AN, Srivastava G, Pittaluga S, Man TK, Ngan H, Collins RJ. " " J. Clin. Pathol.. 1993 Mar ; 46 (3) : 204-7.
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Cheung AN, Srivastava G, Chung LP, Ngan HY, Man TK, Liu YT, Chen WZ, Collins RJ, Wong LC, Ma HK. " " J Reprod Med. 1994 Mar ; 39 (3) : 223-7.
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Man TK, Chintagumpala M, Visvanathan J, Shen J, Perlaky L, Hicks J, Johnson M, Davino N, Murray J, Helman L, Meyer W, Triche T, Wong KK, Lau CC. " " Cancer Res.. 2005 Sep 15; 65 (18) : 8142-50.
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Man TK, Lu XY, Jaeweon K, Perlaky L, Harris CP, Shah S, Ladanyi M, Gorlick R, Lau CC, Rao PH. " " BMC Cancer. 2004 Aug 7; 4 : 45.
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Yang Y, Tsui HC, Man TK, Winkler ME. " " J. Bacteriol.. 1998 Apr ; 180 (7) : 1814-21.
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Rainusso N, Man TK, Lau CC, Hicks J, Shen JJ, Yu A, Wang LL, Rosen JM. " " Cancer Biol. Ther.. 2011 Aug 15; 12 (4) : 278-87.
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Yang Y, Zhao G, Man TK, Winkler ME. " " J. Bacteriol.. 1998 Aug ; 180 (16) : 4294-9.
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Man TK, Zhao G, Winkler ME. " " J. Bacteriol.. 1996 Apr ; 178 (8) : 2445-9.
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Man TK, Pease AJ, Winkler ME. " " J. Bacteriol.. 1997 Jun ; 179 (11) : 3458-69.
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De Bortoli M, Castellino RC, Lu XY, Deyo J, Sturla LM, Adesina AM, Perlaky L, Pomeroy SL, Lau CC, Man TK, Rao PH, Kim JY. " " BMC Cancer. 2006 ; 6 : 223.
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Ma O, Cai WW, Zender L, Dayaram T, Shen J, Herron AJ, Lowe SW, Man TK, Lau CC, Donehower LA. " " Cancer Res.. 2009 Mar 15; 69 (6) : 2559-67.
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Man TK, Stormo GD. " " Nucleic Acids Res.. 2001 Jun 15; 29 (12) : 2471-8.
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Man TK, Li Y, Dang TA, Shen J, Perlaky L, Lau CC. " " Proteome Sci. 2006 ; 4 : 3.
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De Bortoli M, Castellino RC, Skapura DG, Shen JJ, Su JM, Russell HV, Hicks MJ, Man TK, Kim JY. " " Eur. J. Cancer. 2007 May ; 43 (8) : 1308-17.
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Rabin K, Man TK, Lau CC. " " 2008 ; 62 : 173-85; discuss.
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Li Y, Dang TA, Man TK. " " Methods Mol. Biol.. 2012 ; 818 : 81-96.
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Man TK, Yang JS, Stormo GD. " " Nucleic Acids Res.. 2004 ; 32 (13) : 4026-32.
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Harris ZL, Durley AP, Man TK, Gitlin JD. " " Proc. Natl. Acad. Sci. U.S.A.. 1999 Sep 14; 96 (19) : 10812-7.
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Projects

Identification of blood-based biomarkers for ostesosarcoma: CPRIT
Examination of the prognostic significance of p27 in osteosarcoma

Memberships

Children's Oncology Group: Associate Member

American Assoication for Cancer Research: Member

Funding

Harnessing P27 for Prognostication of Pediatric Osteosarcoma #1R01HD074553: (01/01/2013 - 12/31/2015); Grant funding from NIH/NICHD

Targeted Therapies for Metastatic Osteosarcoma #RP140022-P2: (08/01/2010 - 02/29/2016); Grant funding from Cancer Prevention and Research Institute of Texas

Targeting the CXCL10-CXCR3 axis in metastatic osteosarcoma: $1,200,000.00 (08/31/2020 - 08/30/2024); Grant funding from Cancer Prevention and Research Institute of Texas

Skills

Bioinformatics

Cancer Research

Genomics and Proteomics

Languages

Chinese (Cantonese)

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