Sumimasa Arimura, Ph.D.
Assistant Professor
Positions
- Assistant Professor
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Medicine-Gastroenterology
ÌÇÐÄÊÓƵ of Medicine
Houston, TX, US
Education
- BS from Showa Pharmaceutical University
- 03/2002 - Tokyo, Japan
- MS from Showa Pharmaceutical University
- 03/2004 - Tokyo, Japan
- PhD from Kyoto University
- 07/2009 - Kyoto, Japan
- Postdoctoral Fellowship at Kyoto University
- 08/2009 - Kyoto, Japan
- Postdoctoral Fellowship at The University of Tokyo, Assistant Professor at The University of Tokyo
- 01/2018 - Tokyo, Japan
- Research Fellowship at ÌÇÐÄÊÓƵ of Medicine
- 12/2019 - Houston, United States
Certifications
- Pharmacist (Japan)
Professional Statement
We are working on the creation and application of functional cells using state-of-the-art organoid culture technology and transplantation technology. Our multidisciplinary research ranges from understanding the principles of stem cell differentiation, to new insights into stem cell differentiation including the mechanism of paligenesis (rediscovery of differentiated cell division), to the development of innovative therapeutic concepts through disease-specific cell regulation. By optimizing engraftment protocols, our group aims to develop techniques for mucosal epithelial cell replacement therapy, create next generation humanized mice, and explore the functionality of multi-organoid-derived cells in ectopic environments. Our ultimate goal is to translate these breakthroughs into clinically relevant strategies that will revolutionize regenerative medicine. By bridging the gap between basic biology and translational applications, we will open new horizons in cell-based therapy.
Selected Publications
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Arimura S, To S, Mills JC. " Changing fate: how EGFRs "pit" cell vs cell in the stomach. " Gastroenterology. 2024 ; 167 : 441-442.
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Adkins-Threats M*, Arimura S* and Mills JC, et. al. (*Co-1st. authors). " Metabolic regulator ERRγ governs stem cell differentiation into acid-secreting parietal cells. " Cell Stem Cell. 2024 ; 31 : 886-903.
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Arimura S and Yamanashi Y, et. al.. " Loss of Dok-3 in non-tumor cells induces malignant conversion of benign epithelial tumors of the intestine. " Cancer Research Communications. 2022 ; 2 : 1590-600.
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Arimura S and Yamanashi Y, et. al.. " DOK7 gene therapy benefits mouse models of diseases characterized by defects in the neuromuscular junction. " Science. 2014 ; 345 : 1505-8.
Funding
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2026-2029: Grant-in-Aid for Fund for the Promotion of Joint International Research
#25K23934 - Grant funding from Japan Society for the Promotion of Science: JSPS)
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2025-2028: Individual Investigator Research Award: Multi-PI (Other PIs: Ming Hu & Gregory Cuny)
#RP240401 - CPIRT
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2023-2028: NIDDK R01 grant : Co-I (PI: Jason C. Mills)
#R01 DK094989-12 - NIH/NIDDK
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2021-2022: The Texas Medical Center Digestive Diseases Center (TMC-DDC) Pilot/Feasibility Award: PI
#P30DK056338 - NIH/NIDDK
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2018-2019: Research in A Foreign Country (A special 2-year adopter): PI
#201640201 - The Uehara Memorial Foundation (Japan)
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2018-2018: Medical and Pharmaceutical Research in A Foreign Country: PI
#2017R1-1 - Mochida Memorial Foundation (Japan)
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2015-2017: Grant-in-Aid for Encouragement of Young Scientists A: PI
#15H05574 - Japan Society for the Promotion of Science: JSPS)
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2014-2017: The Practical Research Project for Rare/Intractable Diseases: Co-I
#16ek0109003h0003 - Japan Agency for Medical Research and Development: AMED)
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2010-2013: Grant-in-Aid for JSPS Fellow Research: PI
#10J08500 - Japan Society for the Promotion of Science: JSPS)
Languages
Japanese
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