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Sukyeong Lee

Lee

Sukyeong Lee, Ph.D.

Associate Professor

(713) 798-4390

Email

slee@bcm.edu

Positions

Associate Professor
Biochemistry & Molecular Pharmacology
ÌÇÐÄÊÓƵ of Medicine
Houston, Texas, United States
Core Director
Macromolecular X-Ray Crystallography Core
ÌÇÐÄÊÓƵ of Medicine
Houston, Texas, United States
Member
Dan L Duncan Comprehensive Cancer Center
ÌÇÐÄÊÓƵ of Medicine
Houston, Texas, United States
Member
Center for Drug Discovery
ÌÇÐÄÊÓƵ of Medicine
Houston, Texas, United States

Addresses

Department of Biochemistry (Office)
ÌÇÐÄÊÓƵ of Medicine
Houston, TX, 77030-3498
United States
Phone: (713) 798-4390
slee@bcm.edu

Education

Post-Doctoral Fellowship at Yale University
10/2000 - New Haven, Connecticut, United States
Molecular Biophysics and Biochemistry
Post-Doctoral Fellowship at Purdue University
03/1998 - West Lafayette, Indiana, United States
Biological Sciences
PhD from Purdue University
08/1997 - West Lafayette, Indiana, United States
Biological Sciences
MS from Seoul National University
02/1991 - Seoul, Korea
Chemistry
BS from Seoul National University
02/1989 - Seoul, Korea
Chemistry

Honors & Awards

Beginning Grant-in-Aid Award
American Heart Association Texas Affiliate
New Investigator Award
Department of Defense
International Union of Crystallography Young Scientist Travel Grant
International Union of Crystallography
Korean Government Overseas Scholarship
Korean Government
Frederick N. Andrews Doctoral Fellowship
Purdue University
Undergraduate Scholarship
Korea Scholarship Foundation for Future Leaders

Professional Interests

  • Antibiotic Resistance
  • Cryo-electron Microscopy and Tomography
  • Membranes and Membrane Proteins
  • Nano Medicine and Drug Design
  • Protein Structure Function and Protein Folding
  • Structural Biology and Macromolecular Assemblies by Organism

Professional Statement

The broad and long-term research objective of my laboratory is to provide a molecular understanding of the protein quality control machinery that maintains balance inside mitochondria. On-going research focuses on determining the structure, function, and mechanism of molecular chaperones, membrane-associated proteases, protein kinases, and enzymes using a multi-pronged biochemical and biophysical approach. The goal of our research is to provide a detailed mechanistic understanding of mitochondrial quality control proteins in order to exploit this information for rational structure-based drug development.

Websites

Lab Page

Selected Publications

  • Brooks, D., Burke, E., Lee, S. et al.. " " Hum Genet.. 2024 ; 143 : 279-291.
    Pubmed PMID: .
  • Lee, S., Lee, S.B., Sung, N., Xu, W.W., Chang, C., Kim, H.E., Catic, A. and Tsai, F.T.F.. " " Nature Commun.. 2023 Apr 11; 14 : 2028.
    Pubmed PMID: .
  • Mercado, J.M., Lee, S., Chang, C., Sung, N., Soong, L., Catic, A. and Tsai, F.T.F.. " " Proteins. 2022 ; 90 : 1242-1246.
    Pubmed PMID: .
  • Yap, Z.Y., Efthymiou, S., Seiffert, S., Vargas Parra, K., Lee, S. et al.. " " Am. J. Hum. Genet.. 2021 ; 108 : 2368-2384.
    Pubmed PMID: .

Memberships

American Crystallography Association
Member
American Association for the Advancement of Science
Member

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