Positions
- Professor
-
Molecular and Human Genetics
ÌÇÐÄÊÓƵ of Medicine
- Dan L. Duncan Comprehensive Cancer Center Professorship
-
Pediatrics-Oncology
ÌÇÐÄÊÓƵ of Medicine
Houston, TX, US
- Assistant Dean
-
Dual Degree Programs and Pathways, School of Medicine
ÌÇÐÄÊÓƵ of Medicine
- Co-Leader, Pediatric Cancer Program
-
Dan L Duncan Comprehensive Cancer Center
ÌÇÐÄÊÓƵ of Medicine
Houston, Texas, United States
- Director
-
Cancer Genetics Clinical and Research Programs
Texas Children's Hospital
Addresses
- Texas Children's Cancer Genetics Clinic (Clinic)
-
Mark Wallace Tower
6701 Fannin Street, 14th Floor
Houston, TX, 77030
United States
Phone: (832) 822-4240
Education
- Postdoctoral Fellowship at Fred Hutchinson Cancer Research Center
- 06/1993 - Seattle, Washington, United States
- Medical Genetics, Cancer Genetics
- Clinical Fellowship at University Of Washington Affiliate Hospitals
- 06/1993 - Seattle, Washington, United States
- Medical Genetics
- Postdoctoral Fellowship at National Cancer Institute
- 06/1989 - Bethesda, Maryland, United States
- Cancer Genetics
- Residency at University Of Washington Affiliate Hospitals
- 06/1988 - Seattle, Washington, United States
- Internal Medicine
- MD from Harvard Medical School
- 01/1987 - Boston, MA, United States
- PhD from Harvard University
- 05/1987 - Cambridge, MA, United States
- Biophysics
- BS from Massachusetts Institute Of Technology
- 05/1979 - Cambridge, MA, United States
- Chemistry
Certifications
- Clinical Genetics
- American Board of Medical Genetics
Professional Interests
- Cancer predisposition syndromes
Professional Statement
I have had a longstanding focus on the fields of cancer genetics and clinical genomics. My translational research is designed to understand mechanisms of susceptibility to pediatric cancer through large collaborative projects. We have worked closely with Dr. Philip Lupo on a landmark study of the association of birth defects and childhood cancer and are now using whole genome sequencing of these unique patients to identify novel cancer susceptibility genes as well as laboratory research to understand the hereditary basis of rhabdomyosarcoma, an often-lethal tumor in children. I serve as co-PI with Donald (Will) Parsons and Amy McGuire on the NHGRI/NCI- U01 Texas KidsCanSeq trial that studies the incorporation of CLIA clinical genome-scale exome sequencing into the care of childhood cancer patients (solid tumors and brain tumors) in the diverse patient populations across six sites in Texas. I am one of the principal investigators of the Clinical Genome Resource (ClinGen), an international effort dedicated to building a central resource that defines the clinical relevance of genes and variants for use in precision medicine and research.
Websites
Selected Publications
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Li H, Sisoudiya SD, Martin-Giacalone BA, Khayat MM, Dugan-Perez S, (…), Plon SE, Sabo A, Lupo PJ. " " J Natl Cancer Inst.. 2021 ; 113 : 875-883.
Pubmed PMID: . -
Lupo PJ, Schraw JM, Desrosiers TA, Nembhard WN, Langlois PH, (…), Plon SE. " " JAMA Oncol.. 2019 ; 5 : 1150-1158.
Pubmed PMID: . -
Parsons DW, Roy A, Yang Y, Wang T, Scollon S, Bergstrom K, (...), Eng CM, Gibbs RA, Plon SE. " " JAMA Oncol.. 2016 ; 2 : 616-624.
Pubmed PMID: .
Memberships
- American Society of Human Genetics
- Member (06/1990)
- American Association of Cancer Research
- Member (07/1995)
- American College of Medical Genetics and Genomics
- Fellow (06/1995)
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