Positions
- Visiting Professor
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Molecular and Human Genetics
ÌÇÐÄÊÓƵ of Medicine
- Joint Professor
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HGSC:Faculty-General/Basic
ÌÇÐÄÊÓƵ of Medicine
Houston, TX, US
- Professor
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Ophthalmology
University of California Irvine
Irvine, California, United States
Education
- BS from Tsinghua University
- 01/1994 - Beijing, China, People's Rep
- PhD from ÌÇÐÄÊÓƵ Of Medicine
- 01/1999 - Houston, TX, United States
- Post-Doctoral Fellowship at ÌÇÐÄÊÓƵ Of Medicine
- 01/2002 - Houston, United States
Professional Statement
With over 30 million variants in the human genome, which ones are important? Through the lens of human variation and diseases, we focus on advancing our ability to identify, assess, and predict variants with functional consequences using an interdisciplinary approach.
The Chen lab uses innovative genetics and genomics, single cell omics, computational, and imaging tools to understand the connection between genetic variants and human diseases, using the visual system as the model.
We pursue these goals in the following areas:
• Identify genes and mutations underlying human diseases.
• Systematically predict and assess the function consequence of genetic variants across the genome.
• Investigate the changes in transcriptome and epigenome during development and under disease condition at single-cell resolution.
• Develop novel therapeutics, including gene therapy, genome editing, and neural regeneration, for treating the diseases.
Genetics of disease
Genetics plays important role in human visual disorders that affect more than 30 million people in the United States alone. The Chen lab aims at characterizing the genetic factors underlying the neural degenerative diseases in the human visual system, including both the inherited to age related retinal degenerative diseases. A combination of next generation sequencing, single cell omics, patient derived iPSC and retinal organoid, mice and non human primate models, and machine learning and deep learning technologies are used.
Single cell omics
The Chen lab is leading the effort of the constructing the cell atlas of the visual system as part of the Human Cell Atlas (HCA) project (https://www.humancellatlas.org/biological-networks/). Building on this foundation, we aim at gaining insights of the development and the disease of the visual system as the single cell resolution.
Therapeutics
The Chen lab is applying what has been learnt from the genetics to develop novel therapeutics treating human retinal degenerative diseases.
The Chen lab uses innovative genetics and genomics, single cell omics, computational, and imaging tools to understand the connection between genetic variants and human diseases, using the visual system as the model.
We pursue these goals in the following areas:
• Identify genes and mutations underlying human diseases.
• Systematically predict and assess the function consequence of genetic variants across the genome.
• Investigate the changes in transcriptome and epigenome during development and under disease condition at single-cell resolution.
• Develop novel therapeutics, including gene therapy, genome editing, and neural regeneration, for treating the diseases.
Genetics of disease
Genetics plays important role in human visual disorders that affect more than 30 million people in the United States alone. The Chen lab aims at characterizing the genetic factors underlying the neural degenerative diseases in the human visual system, including both the inherited to age related retinal degenerative diseases. A combination of next generation sequencing, single cell omics, patient derived iPSC and retinal organoid, mice and non human primate models, and machine learning and deep learning technologies are used.
Single cell omics
The Chen lab is leading the effort of the constructing the cell atlas of the visual system as part of the Human Cell Atlas (HCA) project (https://www.humancellatlas.org/biological-networks/). Building on this foundation, we aim at gaining insights of the development and the disease of the visual system as the single cell resolution.
Therapeutics
The Chen lab is applying what has been learnt from the genetics to develop novel therapeutics treating human retinal degenerative diseases.
Selected Publications
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Liang Q, Dharmat R, Owen L, Shakoor A, Li Y, Kim S, Vitale A, Kim I, Morgan D, Liang S, Wu N, Chen K, DeAngelis MM, Chen R. " Single-nuclei RNA-seq on human retinal tissue provides improved transcriptome profiling.. " Nat Commun.. 2019 ; 10 : 5743.
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Moshiri A, Chen R, Kim S, Harris RA, Li Y, Raveendran M, Davis S, Liang Q, Pomerantz O, Wang J, Garzel L, Cameron A, Yiu G, Stout JT, Huang Y, Murphy CJ, Roberts J, Gopalakrishna KN, Boyd K, Artemyev NO, Rogers J, Thomasy SM. " " J Clin Invest. 2019 Feb 1; 129 (2) : 863-874.
Pubmed PMID: . -
Kim S, Lowe A, Dharmat R, Lee S, Owen LA, Wang J, Shakoor A, Li Y, Morgan DJ, Hejazi AA, Cvekl A, DeAngelis MM, Zhou ZJ, Chen R*, Liu W. " " Proc Natl Acad Sci U S A. 2019 May 28; 116 (22) : 10824-10833.
Pubmed PMID: . -
Jun Wang, Li Zhao, Xia Wang, Yong Chen, Mingchu Xu, Zachry T. Soens, Zhongqi Ge, Peter Ronghan Wang, Fei Wang and Rui Chen. " " Genome Biology. 2018 ; 19 : 203.
Pubmed PMID: .
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