Rachel Schiff

Rachel Schiff, Ph.D.

Professor

(713) 798-1676

Email

rschiff@bcm.edu

Positions

Professor: Breast Center - Schiff
��Ƶ of Medicine
Houston, TX, US

Member: Dan L Duncan Comprehensive Cancer Center
��Ƶ of Medicine
Houston, Texas, United States

Professional Interests

Biology of ER-positive and HER2-positive breast cancer, targeted therapies, treatment resistance, correlative biomarkers, integrative OMICS and functional genomics

Professional Statement

My research program focuses on understanding the key signaling pathways in breast cancer and on identifying therapeutic strategies to overcome them, particularly treatments targeting the estrogen receptor and the HER2 receptor. Major research themes include the crosstalk between the ER signaling network and growth factor and cellular kinase pathways, the role of ER co-regulators and pioneer factors in breast cancer development and metastasis, the identification of genomic and epigenomic alterations underlying resistance to endocrine and HER2-targeted therapies, and the development of biomarkers for tailored therapeutic interventions.

Websites

Schiff-Osborne lab

Selected Publications

Kessler JD, Kahle KT, Sun T, Meerbrey KL, Schlabach MR, Schmitt EM, Skinner SO, Xu Q, Li MZ, Hartman ZC, Rao M, Yu P, Dominguez-Vidana R, Liang AC, Solimini NL, Bernardi RJ, Yu B, Hsu T, Golding I, Luo J, Osborne CK, Creighton CJ, Hilsenbeck SG, Schiff R,. " " Science. 2012 Jan 20; 335 (6066) : 348-53.
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Sun T, Aceto N, Meerbrey KL, Kessler JD, Zhou C, Migliaccio I, Nguyen DX, Pavlova NN, Botero M, Huang J, Bernardi RJ, Schmitt E, Hu G, Li MZ, Dephoure N, Gygi SP, Rao M, Creighton CJ, Hilsenbeck SG, Shaw CA, Muzny D, Gibbs RA, Wheeler DA, Osborne CK, Schi. " " Cell. 2011 Mar 4; 144 (5) : 703-18.
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Schiff R, Massarweh SA, Shou J, Bharwani L, Arpino G, Rimawi M, Osborne CK. " " Cancer Chemother. Pharmacol.. 2005 Nov ; 56 : 41567.
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Schiff R, Chamness GC, Brown PH. " " Breast Cancer Res.. 2003 ; 5 (5) : 228-31.
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Osborne CK, Schiff R. " " J. Steroid Biochem. Mol. Biol.. 2005 May ; 95 (41279) : 183-7.
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Cui X, Schiff R, Arpino G, Osborne CK, Lee AV. " " J. Clin. Oncol.. 2005 Oct 20; 23 (30) : 7721-35.
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Schiff R, Massarweh S, Shou J, Osborne CK. " " Clin. Cancer Res.. 2003 Jan ; 9 (1) : 447S-54S.
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Schiff R, Lee AV. " " Nat Clin Pract Oncol. 2006 Mar ; 3 (3) : 134-5.
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Cheng CM, Li H, Gasman S, Huang J, Schiff R, Chang EC. " " Mol. Cell. Biol.. 2011 Mar ; 31 (5) : 983-97.
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Schiff R, Massarweh SA, Shou J, Bharwani L, Mohsin SK, Osborne CK. " " Clin. Cancer Res.. 2004 Jan 1; 10 (1) : 331S-6S.
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Osborne CK, Shou J, Massarweh S, Schiff R. " " Clin. Cancer Res.. 2005 Jan 15; 11 (2) : 865s-70s.
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Arpino G, Wiechmann L, Osborne CK, Schiff R. " " Endocr. Rev.. 2008 Apr ; 29 (2) : 217-33.
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Welsh AW, Lannin DR, Young GS, Sherman ME, Figueroa JD, Henry NL, Ryden L, Kim C, Love RR, Schiff R, Rimm DL. " " Clin. Cancer Res.. 2012 Jan 1; 18 (1) : 118-26.
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Creighton CJ, Massarweh S, Huang S, Tsimelzon A, Hilsenbeck SG, Osborne CK, Shou J, Malorni L, Schiff R. " " Cancer Res.. 2008 Sep 15; 68 (18) : 7493-501.
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Giuliano M, Trivedi MV, Schiff R. " " Breast Cancer Res.. 2012 ; 14 (3) : 310.
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Morrison AJ, Herrera RE, Heinsohn EC, Schiff R, Osborne CK. " " Mol. Endocrinol.. 2003 Aug ; 17 (8) : 1543-54.
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Kang YK, Schiff R, Ko L, Wang T, Tsai SY, Tsai MJ, O'Malley BW. " " Cancer Res.. 2008 Oct 1; 68 (19) : 7887-96.
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Sampath L, Kwon S, Ke S, Wang W, Schiff R, Mawad ME, Sevick-Muraca EM. " " J. Nucl. Med.. 2007 Sep ; 48 (9) : 1501-10.
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Osborne CK, Schiff R, Arpino G, Lee AS, Hilsenbeck VG. " " Breast. 2005 Dec ; 14 (6) : 458-65.
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Schiff R, Osborne CK. " " Breast Cancer Res.. 2005 ; 7 (5) : 205-11.
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Rimawi MF, Shetty PB, Weiss HL, Schiff R, Osborne CK, Chamness GC, Elledge RM. " " Cancer. 2010 Mar 1; 116 (5) : 1234-42.
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Harrington WR, Kim SH, Funk CC, Madak-Erdogan Z, Schiff R, Katzenellenbogen JA, Katzenellenbogen BS. " " Mol. Endocrinol.. 2006 Mar ; 20 (3) : 491-502.
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Fuqua SA, Schiff R, Parra I, Moore JT, Mohsin SK, Osborne CK, Clark GM, Allred DC. " " Cancer Res.. 2003 May 15; 63 (10) : 2434-9.
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Zhang X, Podsypanina K, Huang S, Mohsin SK, Chamness GC, Hatsell S, Cowin P, Schiff R, Li Y. " " Oncogene. 2005 Jun 16; 24 (26) : 4220-31.
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Arpino G, Weiss H, Lee AV, Schiff R, De Placido S, Osborne CK, Elledge RM. " " J. Natl. Cancer Inst.. 2005 Sep 7; 97 (17) : 1254-61.
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Osborne CK, Schiff R, Fuqua SA, Shou J. " " Clin. Cancer Res.. 2001 Dec ; 7 (12) : 4338s-4342s; di.
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Oesterreich S, Deng W, Jiang S, Cui X, Ivanova M, Schiff R, Kang K, Hadsell DL, Behrens J, Lee AV. " " Cancer Res.. 2003 Sep 1; 63 (17) : 5203-8.
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Osborne CK, Schiff R. " " J. Clin. Oncol.. 2005 Mar 10; 23 (8) : 1616-22.
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Fuqua SA, Schiff R, Parra I, Friedrichs WE, Su JL, McKee DD, Slentz-Kesler K, Moore LB, Willson TM, Moore JT. " " Cancer Res.. 1999 Nov 1; 59 (21) : 5425-8.
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Osborne CK, Neven P, Dirix LY, Mackey JR, Robert J, Underhill C, Schiff R, Gutierrez C, Migliaccio I, Anagnostou VK, Rimm DL, Magill P, Sellers M. " " Clin. Cancer Res.. 2011 Mar 1; 17 (5) : 1147-59.
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Osborne CK, Schiff R. " " Breast. 2003 Dec ; 12 (6) : 362-7.
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Gutierrez C, Schiff R. " " Arch. Pathol. Lab. Med.. 2011 Jan ; 135 (1) : 55-62.
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Shah C, Miller TW, Wyatt SK, McKinley ET, Olivares MG, Sanchez V, Nolting DD, Buck JR, Zhao P, Ansari MS, Baldwin RM, Gore JC, Schiff R, Arteaga CL, Manning HC. " " Clin. Cancer Res.. 2009 Jul 15; 15 (14) : 4712-21.
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Carpin LB, Bickford LR, Agollah G, Yu TK, Schiff R, Li Y, Drezek RA. " " Breast Cancer Res. Treat.. 2011 Jan ; 125 (1) : 27-34.
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Liu Y, Ludes-Meyers J, Zhang Y, Munoz-Medellin D, Kim HT, Lu C, Ge G, Schiff R, Hilsenbeck SG, Osborne CK, Brown PH. " " Oncogene. 2002 Oct 31; 21 (50) : 7680-9.
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Suo J, Snider SJ, Mills GB, Creighton CJ, Chen AC, Schiff R, Lloyd RE, Chang EC. " " Oncogene. 2011 Feb 10; 30 (6) : 724-36.
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Dave B, Migliaccio I, Gutierrez MC, Wu MF, Chamness GC, Wong H, Narasanna A, Chakrabarty A, Hilsenbeck SG, Huang J, Rimawi M, Schiff R, Arteaga C, Osborne CK, Chang JC. " " J. Clin. Oncol.. 2011 Jan 10; 29 (2) : 166-73.
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Osborne CK, Schiff R. " " Annu. Rev. Med.. 2011 Feb 18; 62 : 233-47.
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Shou J, Massarweh S, Osborne CK, Wakeling AE, Ali S, Weiss H, Schiff R. " " J. Natl. Cancer Inst.. 2004 Jun 16; 96 (12) : 926-35.
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Massarweh S, Osborne CK, Jiang S, Wakeling AE, Rimawi M, Mohsin SK, Hilsenbeck S, Schiff R. " " Cancer Res.. 2006 Aug 15; 66 (16) : 8266-73.
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Gutierrez MC, Detre S, Johnston S, Mohsin SK, Shou J, Allred DC, Schiff R, Osborne CK, Dowsett M. " " J. Clin. Oncol.. 2005 Apr 10; 23 (11) : 2469-76.
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Creighton CJ, Kent Osborne C, van de Vijver MJ, Foekens JA, Klijn JG, Horlings HM, Nuyten D, Wang Y, Zhang Y, Chamness GC, Hilsenbeck SG, Lee AV, Schiff R. " " Breast Cancer Res. Treat.. 2009 Mar ; 114 (2) : 287-99.
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Fu X, Huang C, Schiff R. " " Breast Cancer Res.. 2011 ; 13 (2) : 307.
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Rimawi MF, Mayer IA, Forero A, Nanda R, Goetz MP, Rodriguez AA, Pavlick AC, Wang T, Hilsenbeck SG, Gutierrez C, Schiff R, Osborne CK, Chang JC. " " J. Clin. Oncol.. 2013 Apr 8;
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Mohsin SK, Weiss HL, Gutierrez MC, Chamness GC, Schiff R, Digiovanna MP, Wang CX, Hilsenbeck SG, Osborne CK, Allred DC, Elledge R, Chang JC. " " J. Clin. Oncol.. 2005 Apr 10; 23 (11) : 2460-8.
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Lee AV, Schiff R, Cui X, Sachdev D, Yee D, Gilmore AP, Streuli CH, Oesterreich S, Hadsell DL. " " Clin. Cancer Res.. 2003 Jan ; 9 (1) : 516S-23S.
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Schiff R, Reddy P, Ahotupa M, Coronado-Heinsohn E, Grim M, Hilsenbeck SG, Lawrence R, Deneke S, Herrera R, Chamness GC, Fuqua SA, Brown PH, Osborne CK. " " J. Natl. Cancer Inst.. 2000 Dec 6; 92 (23) : 1926-34.
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Buchwalter G, Hickey MM, Cromer A, Selfors LM, Gunawardane RN, Frishman J, Jeselsohn R, Lim E, Chi D, Fu X, Schiff R, Brown M, Brugge JS. " " Cancer Cell. 2013 Jun 10; 23 (6) : 753-67.
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Sengupta S, Schiff R, Katzenellenbogen BS. " " Breast Cancer Res. Treat.. 2009 Sep ; 117 (2) : 243-51.
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Come SE, Buzdar AU, Arteaga CL, Bissell MJ, Brown MA, Ellis MJ, Goss PE, Green JE, Ingle JN, Lee AV, Medina D, Nicholson RI, Santen RJ, Schiff R, Hart CS. " " Clin. Cancer Res.. 2004 Jan 1; 10 (1) : 327S-330S.
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Zhou C, Nitschke AM, Xiong W, Zhang Q, Tang Y, Bloch M, Elliott S, Zhu Y, Bazzone L, Yu D, Weldon CB, Schiff R, McLachlan JA, Beckman BS, Wiese TE, Nephew KP, Shan B, Burow ME, Wang G. " " Breast Cancer Res.. 2008 ; 10 (6) : R105.
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Creighton CJ, Fu X, Hennessy BT, Casa AJ, Zhang Y, Gonzalez-Angulo AM, Lluch A, Gray JW, Brown PH, Hilsenbeck SG, Osborne CK, Mills GB, Lee AV, Schiff R. " " Breast Cancer Res.. 2010 ; 12 (3) : R40.
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Rimawi MF, Wiechmann LS, Wang YC, Huang C, Migliaccio I, Wu MF, Gutierrez C, Hilsenbeck SG, Arpino G, Massarweh S, Ward R, Soliz R, Osborne CK, Schiff R. " " Clin. Cancer Res.. 2011 Mar 15; 17 (6) : 1351-61.
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Massarweh S, Schiff R. " " Endocr. Relat. Cancer. 2006 Dec ; 13 : S15-24.
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Osborne CK, Bardou V, Hopp TA, Chamness GC, Hilsenbeck SG, Fuqua SA, Wong J, Allred DC, Clark GM, Schiff R. " " J. Natl. Cancer Inst.. 2003 Mar 5; 95 (5) : 353-61.
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Xu J, Wan M, He Q, Bassett RL, Fu X, Chen AC, Shi F, Creighton CJ, Schiff R, Huo L, Liu D. " " Breast Cancer Res. Treat.. 2012 Jul ; 134 (2) : 531-41.
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Toneff MJ, Du Z, Dong J, Huang J, Sinai P, Forman J, Hilsenbeck S, Schiff R, Huang S, Li Y. " " Neoplasia. 2010 Sep ; 12 (9) : 718-26.
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Long JS, Edwards J, Watson C, Tovey S, Mair KM, Schiff R, Natarajan V, Pyne NJ, Pyne S. " " Mol. Cell. Biol.. 2010 Aug ; 30 (15) : 3827-41.
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Huang C, Park CC, Hilsenbeck SG, Ward R, Rimawi MF, Wang YC, Shou J, Bissell MJ, Osborne CK, Schiff R. " " Breast Cancer Res.. 2011 ; 13 (4) : R84.
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Healy NA, Heneghan HM, Miller N, Osborne CK, Schiff R, Kerin MJ. " " Int. J. Cancer. 2012 Nov 15; 131 (10) : 2215-22.
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Massarweh S, Osborne CK, Creighton CJ, Qin L, Tsimelzon A, Huang S, Weiss H, Rimawi M, Schiff R. " " Cancer Res.. 2008 Feb 1; 68 (3) : 826-33.
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Lopez-Tarruella S, Schiff R. " " Clin. Cancer Res.. 2007 Dec 1; 13 (23) : 6921-5.
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Divisova J, Kuiatse I, Lazard Z, Weiss H, Vreeland F, Hadsell DL, Schiff R, Osborne CK, Lee AV. " " Breast Cancer Res. Treat.. 2006 Aug ; 98 (3) : 315-27.
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Meerbrey KL, Hu G, Kessler JD, Roarty K, Li MZ, Fang JE, Herschkowitz JI, Burrows AE, Ciccia A, Sun T, Schmitt EM, Bernardi RJ, Fu X, Bland CS, Cooper TA, Schiff R, Rosen JM, Westbrook TF, Elledge SJ. " " Proc. Natl. Acad. Sci. U.S.A.. 2011 Mar 1; 108 (9) : 3665-70.
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Arpino G, Gutierrez C, Weiss H, Rimawi M, Massarweh S, Bharwani L, De Placido S, Osborne CK, Schiff R. " " J. Natl. Cancer Inst.. 2007 May 2; 99 (9) : 694-705.
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Massarweh S, Schiff R. " " Clin. Cancer Res.. 2007 Apr 1; 13 (7) : 1950-4.
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Chen AC, Migliaccio I, Rimawi M, Lopez-Tarruella S, Creighton CJ, Massarweh S, Huang C, Wang YC, Batra SK, Gutierrez MC, Osborne CK, Schiff R. " " Breast Cancer Res. Treat.. 2012 Jul ; 134 (2) : 583-93.
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Nabha SM, Glaros S, Hong M, Lykkesfeldt AE, Schiff R, Osborne K, Reddy KB. " " Oncogene. 2005 Apr 28; 24 (19) : 3166-76.
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