Penelope E Bonnen, Ph.D., B.S.
Associate Professor
Positions
- Associate Professor
-
Molecular and Human Genetics
ÌÇÐÄÊÓƵ of Medicine
Houston, Texas, United States
- Associate Professor
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Molecular Physiology & Biophysics
ÌÇÐÄÊÓƵ of Medicine
Houston, Texas, United States
- Faculty Member
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Computational and Integrative Biomedical Research Center
ÌÇÐÄÊÓƵ of Medicine
Houston, Texas, United States
- Faculty Member
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Program in Structural & Computational Biology and Molecular Biophysics
ÌÇÐÄÊÓƵ of Medicine
Houston, Texas, United States
- Faculty Senator
-
ÌÇÐÄÊÓƵ of Medicine
Houston, Texas, United States
- Member
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Dan L Duncan Comprehensive Cancer Center
ÌÇÐÄÊÓƵ of Medicine
Houston, Texas, United States
Education
- BS from Texas A&M University
- 01/1993 - College Station, Texas, United States
- PhD from ÌÇÐÄÊÓƵ Of Medicine
- 01/2002 - Houston, TX, United States
- Post-Doctoral Fellowship at The Rockefeller University
- 01/2007 - New York, NY, United States
Professional Interests
- Functional genomics, bioinformatics, metabolomics and human genetics of mitochondrial and metabolic disease.
Professional Statement
Personalized genomics to identify genes causing Mitochondrial Disease
Mitochondrial disease has an incidence of 1/5000 and can affect every organ system. Childhood-onset mitochondrial disease most often results from recessive mutations in the nuclear genome; however, the vast majority of cases remain without a molecular diagnosis and no effective treatments, thus underscoring the critical need to identify the genetic aberrations driving these disorders. We are leveraging a personalized functional genomics approach combining genome-wide sequencing, mitochondrial functional profiling in patient cells and functional genomics to identify validated novel mitochondrial disease genes. This project will significantly advance the diagnosis and treatment of mitochondrial disease, as well as provide new insights into the mechanisms underlying the pathology of mitochondrial respiratory chain disorders and commonly occurring conditions associated with mitochondrial dysfunction such as cancer, diabetes and neurodegeneration.
Mitochondrial disease has an incidence of 1/5000 and can affect every organ system. Childhood-onset mitochondrial disease most often results from recessive mutations in the nuclear genome; however, the vast majority of cases remain without a molecular diagnosis and no effective treatments, thus underscoring the critical need to identify the genetic aberrations driving these disorders. We are leveraging a personalized functional genomics approach combining genome-wide sequencing, mitochondrial functional profiling in patient cells and functional genomics to identify validated novel mitochondrial disease genes. This project will significantly advance the diagnosis and treatment of mitochondrial disease, as well as provide new insights into the mechanisms underlying the pathology of mitochondrial respiratory chain disorders and commonly occurring conditions associated with mitochondrial dysfunction such as cancer, diabetes and neurodegeneration.
Selected Publications
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Besse A, Wu P, Bruni F, Donti T, Graham BH, Craigen WJ, McFarland R, Moretti P, Lalani S, Scott KL, Taylor RW, Bonnen PE. " " Cell Metab. 2015 Mar 3; 21 : 417-27.
Pubmed PMID: . -
Bonnen PE, Yarham JW, Besse A, Wu P, Faqeih EA, Al-Asmari AM, Saleh MA, Eyaid W, Hadeel A, He L, Smith F, Yau S, Simcox EM, Miwa S, Donti T, Abu-Amero KK, Wong LJ, Craigen WJ, Graham BH, Scott KL, McFarland R, Taylor RW. " " Am J Hum Genet. 2013 Sep 5; 93 (3) : 471-81.
Pubmed PMID: . -
Craigen WJ, Graham BH, Wong LJ, Scaglia F, Lewis RA, Bonnen PE. " " BMC Med Genet. 2013 Aug 16; 14 : 83.
Pubmed PMID: . -
Bacino CA, Dhar SU, Brunetti-Pierri N, Lee B, Bonnen PE. " " Am J Med Genet A. 2012 ; 158 (11) : 2917-24.
Pubmed PMID: .
Memberships
- American Society of Human Genetics
- Member
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