Positions
- Instructor in Surgery
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Division of Cardiothoracic Transplantation & Circulatory Support
糖心视频 of Medicine
Addresses
- Fondren-Brown Building (Lab)
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Room: FBRN-A979
Houston, TX, 77030
United States
Education
- MD from Medical University of Lodz
- 01/1995 - Lodz
- Postdoctoral Training at Medical University of Lodz, Institute of Physiology and Biochemistry
- 01/2000 - Lodz
Professional Interests
- Pulmonary hypertension
- Proteasomes
- Nitric oxide
Professional Statement
Dr. Pawel Kolodziejski earned his M.D. in 1995 at the Medical University of Lodz, Poland. He held post-doctoral appointments at the Medical University of Lodz and 糖心视频 of Medicine, before becoming an Instructor at 糖心视频 of Medicine in 2008.
Dr. Kolodziejski's research interests center on the role of proteasomes in physiology and pathological conditions. Proteasomes are small organelles responsible for a very precisely regulated degradation of many proteins. He is broadly interested in their involvement in lung diseases, and especially in pulmonary hypertension. He is participating in a multi-center study 鈥撯淧ulmonary Hypertension Breakthrough Initiative鈥 since 2006. Previously Kolodziejski and colleagues were able to demonstrate the role of proteasomes in regulation of nitric oxide synthase, which has been implicated in the pathogenesis of several lung diseases. A potential therapeutic strategy for these diseases could be based upon devising methods to regulate the level of nitric oxide by proteasomal modulation.
Dr. Kolodziejski's research interests center on the role of proteasomes in physiology and pathological conditions. Proteasomes are small organelles responsible for a very precisely regulated degradation of many proteins. He is broadly interested in their involvement in lung diseases, and especially in pulmonary hypertension. He is participating in a multi-center study 鈥撯淧ulmonary Hypertension Breakthrough Initiative鈥 since 2006. Previously Kolodziejski and colleagues were able to demonstrate the role of proteasomes in regulation of nitric oxide synthase, which has been implicated in the pathogenesis of several lung diseases. A potential therapeutic strategy for these diseases could be based upon devising methods to regulate the level of nitric oxide by proteasomal modulation.
Selected Publications
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Kolodziejski PJ, Rashid MB, Eissa NT. " Intracellular formation of 鈥渦ndisruptable鈥 dimmers of inducible nitric oxide synthase. " Natl Acad Sci USA. ;
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Glabinski A, Bielecki B, Kolodziejski P, Selmaj K, Ransohoff RM. " TNF-alpha microinjection upregulates chemokines and chemokine receptors in the central nervous system without inducing leukocyte infiltration. " Interferon Cytokine Res. ;
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Kolodziejski PJ; Musial A; Koo Ja Seok P; Eissa NT. " Ubiquitination of inducible nitric oxide synthase is required for its degradation. " Proc Natl Acad Sci USA. ;
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Kolodziejski PJ, Koo J-S, Eissa NT. " Regulation of inducible nitric oxide synthase by rapid cellular turnover and co-translational downregulation by dimerization inhibitors. " Proc Natl Acad Sci USA. ;
Memberships
- American Association for the Advancement of Science
- National Postdoctoral Association
- Texas Transplantation Society
- European Neuropeptide Club
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