Positions
- Associate Professor
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Department of Medicine Section of Gastroenterology and Hepatology
ÌÇÐÄÊÓƵ of Medicine
Houston, Texas
- Adjunct Associate Professor
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Department of Pediatrics Division of Gastroenterology, Hepatology & Nutrition Cincinnati Children's Hospital
University of Cincinnati
Cincinnati, Ohio
- Member
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Dan L Duncan Comprehensive Cancer Center
ÌÇÐÄÊÓƵ of Medicine
Houston, Texas, United States
- Core Director
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Digestive Diseases Center
Texas Medical Center
/research/centers/digestive-disease
Addresses
- BCM-Alkek Graduate School (Lab)
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Room: BCMN-N1301
Houston, TX, 77030
United States
Education
- BS from Louisiana State University
- Baton Rouge, Louisiana, United States
- Microbiology and Biochemistry
- PhD from ÌÇÐÄÊÓƵ of Medicine
- Houston, Texas, United States
- Cell and Molecular Biology
- Post-Doctoral Fellowship at ÌÇÐÄÊÓƵ of Medicine
- Houston, Texas, United States
- Molecular and Human Genetics
Professional Interests
- Mechanisms that control intestinal development and homeostasis
- Human Enteroids
Professional Statement
My laboratory is focused on understanding the mechanisms that control intestinal development and homeostasis, and translating this knowledge into novel therapeutic approaches to treat diseases of the intestine such as IBD and colorectal cancer. My laboratory has elucidated roles for epithelial transcription factors such as Atoh1 (Math1), Gfi1, and Spdef in development and differentiation of the intestine. Moreover, my laboratory has translated these findings to human diseases, by showing that Atoh1 and its target Spdef are tumor suppressors that are frequently silenced in colon cancers, and that these genes are essential targets of Notch inhibitory drugs. In addition to these mechanistic studies, we have recently developed novel organ culture methods to direct differentiation of human pluripotent stem cells into intestinal tissue to study intestinal development and disease, and we have used intestinal stem cell-derived organoids in quantitative assays to evaluate intestinal stem cell activity.
Websites
Selected Publications
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Spence JR, Mayhew CN, Rankin SA, Kuhar MF, Vallance JE, Tolle K, Hoskins EE, Kalinichenko VV, Wells SI, Zorn AM, Shroyer NF, Wells JM.. " " 2011 Feb ;
Pubmed PMID: . -
Noah TK, Shroyer NF.. " " 2013 ;
Pubmed PMID: . -
Lo Y-H., Chung, E., Li, Z., Wan, Y-W., Mahe, M.M., Chen, M-S., Noah, T.K., Bell, K.N., Yalamanchili, H.K., Klisch, T.J., Liu, Z., Park, J-S., Shroyer, N.F.. " " Cellular and Molecular Gastroenterology and Hepatology.. 2017 ; 3 : 51-71.
Pubmed PMID: . -
Lo Y-H., Noah, T.K., Chen, M-S., Zou, W., Borras, E., Vilar, E., Shroyer, N.F.. " " Gastroenterology. 2017 ; 153 : 205-218.
Pubmed PMID: .
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