Nagireddy Putluri

Nagireddy Putluri, Ph.D

Professor

Email

putluri@bcm.edu

Positions

Professor: Molecular and Cellular Biology
��Ƶ of Medicine
Houston, Texas, United States

Education

PhD from Indian Institute Of Chemical Technology-IICT: 01/2007 - Hyderabad, AP, India; Analytical Chemistry-Mass Spectrometry, Metabolomics, Proteomics

MS from Osmania University: 07/2001 - HYDERABAD, AP, India; ORGANIC CHEMISTRY

BS from Osmania University: 06/1998 - HYDERABAD, AP, India

Post-Doctoral Fellowship at Pennington Biomedical Research Center, LSU: 07/2007 - Baton Rouge, Louisiana, United States; Proteomics

Post-Doctoral Fellowship at Medical College of Georgia: 01/2009 - Augusta, Georgia, United States; Metabolomics

Professional Statement

My research is centered on leveraging advanced mass spectrometry technologies to investigate metabolic reprogramming in cancer development and progression. I have established a robust and independent research program with a particular focus on bladder cancer. My team has identified key metabolic alterations associated with tobacco smoking and health disparities, and more recently, elucidated the role of oncogenic signaling pathways in driving bladder cancer progression. These studies have culminated in several impactful publications in high-profile journals, including Nature Communications (2024), JCI Insight (2024), Oncogene (2020), Clinical Cancer Research (2019), European Urology Focus (2017), Oncotarget (2017), and The Journal of Urology (2016). I maintain active collaborations with clinicians to translate these findings into meaningful advances in biomarker discovery and clinical applications. Since joining ��Ƶ of Medicine as Director of the Cancer Metabolomics Core, I have led the strategic development and expansion of a state-of-the-art metabolomics infrastructure. Originally launched as an institutional core, the facility has since evolved into a Texas Medical Center-wide service unit, supporting investigators across a broad spectrum of research areas. I have developed and implemented a comprehensive suite of mass spectrometry-based platforms, including targeted metabolite profiling, untargeted global metabolomics, lipidomics, and more recently, in vitro metabolic flux analysis.
These integrated platforms enable high-resolution, quantitative interrogation of metabolic pathways, contributing to a deeper understanding of cancer biology and metabolic disease. My work has contributed to numerous high-impact publications in leading journals such as Cell (2014), Science (2018), Nature (2017, 2018), Journal of Clinical Investigation (2014, 2015, 2017), Cell Metabolism (2017), and Cancer Research (2011, 2016).
Through both my research and leadership, I remain committed to bridging basic and translational science with the ultimate goal of identifying metabolic vulnerabilities and developing innovative strategies for cancer diagnosis, prognosis, and therapy.

Websites

Cancer Metabolomics

Putluri Lab Website

Selected Publications

Kornberg MD, Bhargava P, Kim PM, Putluri V, Snowman AM, Putluri N, Calabresi PA, Snyder SH.. " " Science. 2018 Apr 27; 360 (6387) : 449-453.
Pubmed PMID: .
Vantaku V, Amara CS, Piyarathna DWB, Donepudi SR, Ambati CR, Putluri V, Tang W, Rajapakshe K, Estecio MR, Terris MK, Castro PD, Ittmann MM, Williams SB, Lerner SP, Sreekumar A, Bollag R, Coarfa C, Kornberg MD, Lotan Y, Ambs S, Putluri N.. " " Carcinogenesis. 2019 ;
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Zhang X, Wang X, Wang XQD, Su J, Putluri N, Zhou T, Qu Y, Jeong M, Guzman A, Rosas C, Huang YN, Sreekumar A, Li W, Goodell MA. " " Blood. 2020 ;
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Dasgupta S, Rajapakshe K, Zhu B, Nikolai BC, Yi P, Putluri N, Choi JM, Jung SY, Coarfa C, Westbrook TF, Zhang XH, Foulds CE, Tsai SY, Tsai MJ, O'Malley BW.. " " Nature. 2018 Apr 3; 556 (7700) : 249-254.
Pubmed PMID: .
Vareed SK, Bhat VB, Thompson C, Vasu VT, Fermin D, Choi H, Creighton CJ, Gayatri S, Lan L, Putluri N, Thangjam GS, Kaur P, Shabahang M, Giri JG, Nesvizhskii AI, Asea AA, Cashikar AG, Rao A, McLoughlin J, Sreekumar A. " " PLoS ONE. 2011 ; 6 (3) : e17177.
Pubmed PMID: .
Kaushik AK, Vareed SK, Basu S, Putluri V, Putluri N, Panzitt K, Brennan CA, Chinnaiyan AM, Vergara IA, Erho N, Weigel NL, Mitsiades N, Shojaie A, Palapattu G, Michailidis G, Sreekumar A. " " J Proteome Res. 2013 ;
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Putluri N, Shojaie A, Vasu VT, Nalluri S, Vareed SK, Putluri V, Vivekanandan-Giri A, Byun J, Pennathur S, Sana TR, Fischer SM, Palapattu GS, Creighton CJ, Michailidis G, Sreekumar A. " " PLoS ONE. 2011 ; 6 (7) : e21417.
Pubmed PMID: .
Putluri N, Shojaie A, Vasu VT, Vareed SK, Nalluri S, Putluri V, Thangjam GS, Panzitt K, Tallman CT, Butler C, Sana TR, Fischer SM, Sica G, Brat DJ, Shi H, Palapattu GS, Lotan Y, Weizer AZ, Terris MK, Shariat SF, Michailidis G, Sreekumar A.. " " Cancer Research. 2011 Oct ;
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Bader DA, Hartig SM, Putluri V, Foley C, Hamilton MP, Smith EA, Saha PK, Panigrahi A, Walker C, Zong L, Martini-Stoica H, Chen R, Rajapakshe K, Coarfa C, Sreekumar A, Mitsiades N, Bankson JA, Ittmann MM, O'Malley BW, Putluri N, McGuire SE. " " Nature Metabolism. 2019 ;
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Vantaku V, Dong J, Ambati CR, et. al... Coarfa C, Putluri N. " " Clinical Cancer Research. 2019 ;
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Terunuma, A. Putluri, N. Sreekumar, A. and Ambs, S. " " J Clin Invest. 2014 Jan ; 124 : 398-412.
Pubmed PMID: .
Dey P et. al.... DePinho RA. " " Cancer Discovery. 2020 Feb ;
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Hu Q, et. al........Yang L.. " " Nature Immunology. 2019 ;
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Putluri N, Maity S, Kommangani R, Creighton CJ, Putluri V, Chen F, Nanda S, Bhowmik SK, Terunuma A, Dorsey T, Nardone A, Fu X, Shaw C, Sarkar TR, Schiff R, Lydon JP, O'Malley BW, Ambs S, Das GM, Michailidis G, Sreekumar A. " " Neoplasia. 2014 May ; 16 (5) : 390-402.
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Scherp P, Putluri N, LeBlanc GJ, Wang ZQ, Zhang XH, Yu Y, Ribnicky D, Cefalu WT, Kheterpal I. " " J Proteomics. 2012 ;
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Scherp P, Putluri N, Leblanc GJ, Wang ZQ, Zhang XH, Yu Y, Ribnicky D, Cefalu WT, Kheterpal I. " " J Proteomics. 2012 Jun 18; 75 (11) : 3199-210.
Pubmed PMID: .
Stashi E, Lanz RB, Mao J, Michailidis G, Zhu B, Kettner NM, Putluri N, Reineke EL, Reineke LC, Dasgupta S, Dean A, Stevenson CR, Sivasubramanian N, Sreekumar A, Demayo F, York B, Fu L, O'Malley BW. " " Cell Rep. 2014 Feb ;
Pubmed PMID: .
Andreas Martin Lisewski, Joel P. Quiros, et. al. " Supergenomic Network Compression and the Discovery of EXP1 as a Glutathione Transferase Inhibited by Artesunate. " cell. 2014 Aug ;
Amara CS, Kami Reddy KR, et al.. Msaouel P, Kavuri SM, Putluri N.. " " Nature Communication. 2024 Feb 14;
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Memberships

Sigma Xi: Active Member (01/2010)

American Association for Cancer Research (AACR): Associate Member (01/2009)

American Society of Mass Spectrometry: Member (01/2007)

American Urological Association - AUA: Member (01/2017)

Funding

Elucidating the Role of Xenobiotic Metabolism in Bladder Cancer Progression: $796,000.00 (07/01/2015 - 06/30/2019); Grant funding from American Cancer Society

RACIAL DISPARITY IN BLADDER CANCER AND IDENTIFICATION OF ALTERED METABOLISM IN AFRICAN AMERICAN COMPARE TO EUROPEAN BLADDER CANCER #R01CA220297: $1,819,903.00 (06/05/2017 - 06/05/2022); Grant funding from National Cancer Institute/NIH

IDENTIFY THE DNA ADDUCT AND ASSOCIATED METABOLIC ALTERATIONS IN BLADDER CANCER OF SMOKERS #RO1CA216426: $1,980,358.00 (04/01/2018 - 03/31/2023); Grant funding from National Cancer Institute/NIH

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