ÌÇÐÄÊÓƵ

Email

palaniap@bcm.edu

Positions

Assistant Professor

Pathology & Immunology
Center for Drug Discovery
ÌÇÐÄÊÓƵ of Medicine
Houston, Texas, United States

Group Leader

DNA encoded chemical library screening
Center for Drug Discovery
ÌÇÐÄÊÓƵ of Medicine

Member

Dan L Duncan Comprehensive Cancer Center

Education

PhD from University of Madras

Chennai, India

Postdoctoral Training at University of Michigan

Ann Arbor, Michigan, United States

Professional Interests

• Breast cancer
• DNA encoded chemical library screening
• Drug Discovery and Development

Websites

Selected Publications

• Devakrishnan AK, Madasu C, Wang Y, Modukuri R, Bohren KM, MacKenzie KR, Young DW, Fuqua SAW, Matzuk MM and Palaniappan M. " " npj Breast Cancer. 2025 Nov 12; 125 (11) : 1-15.
• Palaniappan M and Bohren KM.. " " J Steroid Biochem Mol Biol.. 2025 Jul ;
  Pubmed PMID: .
• Palaniappan M. " " Biomedicines. 2024 Dec ; 12 (Estrogen for the Treatment and Prevention of Breast Cancer) : 1-17.
• Palaniappan M*, Nguyen L, Grimm SL Xi Y, Xia Z, Li W, Coarfa C. " " PloS One. 2019 ;
  Pubmed PMID: .
• Palaniappan M, Edwards D, Creighton CJ, Medina D, Conneely OM.. " " PLoS One. 2018 Mar ;
  Pubmed PMID: .
• Modukuri RK, Monsivais D, Li F, Palaniappan M, Bohren KM, Tan Z, Ku AF, Wang Y, Madasu C, Li JY, Tang S, Miklossy G, Palmer SS, Young DW, Matzuk MM.. " " J Med Chem. 2023 ;
  Pubmed PMID: .
• Judge A, Sankaran B, Hu L, Palaniappan M, Birgy A, Prasad BVV, Palzkill T.. " " PNAS. 2024 Mar 19; 121(12) : :e2313513121.
  Pubmed PMID: .
• Ku AF, Sharma KL, Ta HM, Sutton CM, Bohren KM, Wang Y, Chamakuri S, Chen R, Hakenjos JM, Jimmidi R, Kent K, Li F, Li JY, Ma L, Madasu C, Palaniappan M, Palmer SS, Qin X, Robers MB, Sankaran B, Tan Z, Young DW, Teng M, Kim C, Matzuk MM.. " " Science. 2024 May 23; 384(6698) : 885-890.
  Pubmed PMID: .
• Lu S, Hu L, Lin H, Judge A, Rivera P, Palaniappan M, Sankaran B, Wang J, Prasad BVV, Palzkill T.. " " Nat Commun. 2022 ;
  Pubmed PMID: .
• Park S, Fan J, Chamakuri S, Palaniappan M, Sharma K, Qin X, Wang J, Tan Z, Judge A, Hu L, Sankaran B, Li F, Prasad BVV, Matzuk MM, Palzkill T.. " " J Med Chem.. 2024 Jan 11; 67(1) : 620-642..
  Pubmed PMID: .
• Li JY, Miklossy G, Modukuri RK, Bohren KM, Yu Z, Palaniappan M, Faver JC, Riehle K, Matzuk MM, Simmons N.. " " Bioconjug Chem.. 2019 Aug ;
  Pubmed PMID: .
• Du HC, Simmons N, Faver JC, Yu Z, Palaniappan M, Riehle K, Matzuk MM.. " " Org Lett. 2019 ;
  Pubmed PMID: .
• Palaniappan M, Menon KM.. " " Mol Endocrinol. 2010 ;
  Pubmed PMID: .
• Palaniappan M, Menon KM. " " Mol Endocrinol. 2012 Jul ;
  Pubmed PMID: .
• Will MA, Palaniappan M, Peegel H, Kayampilly P, Menon KM. " " Fertil Steril. 2012 Jul ;
  Pubmed PMID: .
• Palaniappan M, Menon KM.. " " Biol Reprod. 2009 ;
  Pubmed PMID: .
• Muthusamy T, Murugesan P, Srinivasan C, Balasubramanian K.. " " Mol Cell Biochem. 2011 Jun ;
  Pubmed PMID: .
• Palaniappan M, Menon B, Menon KM. " " Mol Cell Endocrinol.. 2013 ;
  Pubmed PMID: .
• Taylor DM, Anglin J, Park S, Ucisik MN, Faver JC, Simmons N, Jin Z, Palaniappan M, Nyshadham P, Li F, Campbell J, Hu L, Sankaran B, Prasad BVV, Huang H, Matzuk MM, Palzkill T.. " " ACS Infect Dis.. 2020 May ; 6
  Pubmed PMID: .
• Ye Q, Belabed H, Wang Y, Yu Z, Palaniappan M, Li JY, Kalovidouris SA, MacKenzie KR, Teng M, Young DW, Fujihara Y, Matzuk MM.. " " Andrology. 2022 ;
  Pubmed PMID: .
• Madasu C, Liao Z, Parks SE, Sharma KL, Bohren KM, Ye Q, Li F, Palaniappan M, Tan Z, Yuan F, Creighton CJ, Tang S, Masand RP, Guan X, Young DW, Monsivais D, Matzuk MM.. " " PNAS. 2024 May 8; 121(19) : e2322934121.

Show 17 more publications

Memberships

The Endocrine Society

American Association for Cancer Research (AACR)

Active Member

Funding

Development of Next-Generation Estrogen Receptor Mutant Inhibitors for Endocrine Resistant Metastatic Breast Cancer
#RP220524

$769,179.00   (03/01/2022 - 02/28/2025)

Grant funding from CPRIT

Development of a Precision Drug to target Y537S Mutant Estrogen Receptor in Metastatic Breast Cancer
#R03CA259664

$160,000.00   (12/13/2021 - 11/30/2023)

Grant funding from NIH/NCI

Developing Allosteric Small-Molecule Inhibitors of CDK6/Cyclin D to Overcome Resistance in Breast Cancer
#DBG-25-1434888-01-CCB

$297,000.00   (09/01/2025 - 08/31/2027)

Grant funding from American Cancer Society

Breast SPORE Career Enhancement Program Award

(08/01/2022 - 07/31/2023)

Grant funding from NIH/NCI

Skills

SCIENTIST