Mihail G. Chelu

Mihail G. Chelu, M.D., Ph.D.

Professor

Email

mihail.chelu@bcm.edu

Positions

Professor: Medicine - Cardiology
��Ƶ of Medicine
Houston, Texas, United States

Director of Electrophysiology: ��Ƶ of Medicine
Houston, Texas, United States

Director of Clinical Electrophysiology Research: ��Ƶ of Medicine
Houston, Texas, United States

Medical Director: Inherited Arrhythmia and Cardiomyopathy Clinic
��Ƶ of Medicine
Houston, Texas, United States

Associate Program Director: Electrophysiology Fellowship
��Ƶ of Medicine

Addresses

Fannin Tower - Cardiology (Clinic): 6624 Fannin Street, Ste. 2480
Houston, TX, 77030
United States
Phone: (713) 529-5530

Education

MD from Iuliu Hatieganu University of Medicine and Pharmacy: 09/2000 - Cluj-Napoca, Romania

PhD from ��Ƶ of Medicine: 09/2006 - Houston, Texas, United States; Molecular Physiology and Biophysics

Clinical Fellowship at Texas Heart Institute at St Luke's Episcopal Hospital/��Ƶ of Medicine: 06/2013 - Houston, Texas, United States; Cardiac Electrophysiology

Clinical Fellowship at Texas Heart Institute at St Luke's Episcopal Hospital/��Ƶ of Medicine: 06/2012 - Houston, Texas, United States; Cardiovascular Disease

Postdoctoral Fellowship at ��Ƶ of Medicine: 03/2009 - Houston, Texas, United States; Internal Medicine/Clinical Investigator Pathway

Residency at University of Texas Health Science Center: 03/2009 - Houston, Texas, United States; Internal Medicine/Clinical Investigator Pathway

Internship at University of Texas Health Science Center: 03/2006 - Houston, Texas, United States; Internal Medicine

MS from Babes-Bolyai University: 06/1997 - Cluj-Napoca, Romania; Theoretical Physics

BS from Babes-Bolyai University: 06/1996 - Cluj-Napoca, Romania; Physics

Certifications

Clinical Cardiac Electrophysiology: American Board of Internal Medicine

Cardiovascular Disease: American Board of Internal Medicine

Honors & Awards

Associate Fellow: American College of Cardiology

Professional Interests

Clinical Cardiac Electrophysiology
Inherited cardiac arrhythmias and cardiomyopathies
Sudden cardiac death
Ablation of complex atrial flutters and fibrillation
Ablation of ventricular arrhythmias
Implantation of pacemakers, defibrillators, cardiac resynchronization therapy devices
Conduction system pacing

Professional Statement

Dr. Chelu’s research interests include:
1) molecular mechanisms and genetics of cardiac arrhythmias and cardiomyopathies;
2) clinical trials of devices and medications for treatment of arrhythmias;
3) outcomes research of interventions for treatment of cardiovascular diseases;
4) integration of sensors and mobile platforms to monitor, identify disease signatures, and determine impact on quality of life.

Websites

Selected Publications

Kim JA, Kim SE, Ellenbogen KA, Vijayaraman P, Chelu MG.. " " J Cardiovasc Electrophysiol.. 2023 ; 34 (8) : 1718-1729.
Pubmed PMID: .
Haddadin F, Majmundar M, Jabri A, Pecha L, Scott C, Daher M, Kumar A, Kalra A, Fram R, Haddadin F, Almahameed S, DeSimone CV, Cha YM, Mulpuru SK, Ellenbogen KA, Saeed M, Chelu MG, Deshmukh AJ.. " " Heart Rhythm.. 2022 ; 19 (8) : 1289-1296.
Pubmed PMID: .
Kim JA, Khan K, Kherallah R, Khan S, Kamat I, Ulhaq O, Marashly Q, Chelu MG.. " " J Interv Card Electrophysiol.. 2022 ; 66 (3) : 737-756.
Pubmed PMID: .
Chelu MG, Sarma S, Sood S, Wang S, van Oort RJ, Skapura DG, Li N, Santonastasi M, Müller FU, Schmitz W, Schotten U, Anderson ME, Valderrábano M, Dobrev D, Wehrens XH. " " J Clin Invest. 2009 Jul ; 119 (7) : 1940-51.
Pubmed PMID: .
Li T, Marashly Q, Kim JA, Li N, Chelu MG. " Cardiac conduction diseases: understanding the molecular mechanisms to uncover targets for future treatments. " Expert Opin Ther Targets. 2024 ;
Vijayaraman P, Sharma PS, Cano O, Ponnusamy SS, Herweg B, Zanon F, Jastrzebski M, Zou J, Chelu MG, Vernooy K, Whinnett ZI, ... , Subzposh FA, Ellenbogen KA. " Comparison of Left Bundle-Branch Area Pacing to Biventricular Pacing in Candidates for Resynchronization Therapy. " J Am Coll Cardiol.. 2023 ;
Lynch PT, Maloof A, Badjatiya A, Safavi-Naeini P, Segar MW, Kim JA, Marashly Q, Molina-Razavi JE, Simpson L, Oberton SB, Xie LX, Civitello A, Mathuria N, Cheng J, Rasekh A, Saeed M, Razavi M, Nair A, Chelu MG. " Mortality in Recipients of Durable Left Ventricular Assist Devices Undergoing Ventricular Tachycardia Ablation. " JACC Clin Electrophysiol. 2024 ;

Funding

Left vs Left RCT #PLACER 2021C3- 24160: $30,777,361.00 (01/01/2023 - 06/30/2029); Patient-Centered Outcomes Research Institute (PCORI); Cardiac Resynchronization Therapy Using His/Left Bundle Branch Pacing vs Biventricular Pacing with a Left Ventricular Epicardial Lead in Patients with Heart Failure (HF) with Left Ventricular Ejection Fraction (LVEF) ≤ 50% and with either a Wide QRS Complex (> 130 ms) or with/anticipated > 40% Pacing Randomized Clinical Trial (RCT) (NCT05650658) The goal is test the comparative effectiveness of His/Left Bundle Branch Pacing in relation to patient centered outcomes (quality of life, heart failure hospitalization, mortality) and comparative safety in relation to device-related complications and re-interventions (e.g., lead dislodgement, infection) relative to standard of care biventricular pacing in patients with heart failure with LVEF≤50% and an indication for cardiac resynchronization therapy by the current guidelines. The primary outcome is death from any cause or HF leading to hospitalization. The study is expected to enroll and randomize 2136 participants at 65 investigational sites in USA and Canada. The enrollment is ongoing with 469 participants randomized at 63 active sites as of April 10, 2025.

Mechanisms of Lamin A/C-mediated Cardiac Conduction Disorders #1R01HL166832: (09/25/2024 - 06/30/2029); NIH/NHLBI

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