Matthew McGinley

Matthew McGinley, Ph.D.

Associate Professor

Email

matthew.mcginley@bcm.edu

Positions

Associate Professor: Neuroscience
��Ƶ of Medicine

Addresses

McGinley Lab (Lab): Duncan Neurological Research Institute
Room: NRI N.1265.08
Houston, TX, 77030
United States
Phone: (832) 824-3966
mmcginle@bcm.edu

McGinley Lab (Office): Duncan Neurological Research Institute
Room: NRI N.1265.08
Houston, TX, 77030
United States
Phone: (832) 824-3966
mmcginle@bcm.edu

Education

BS from University of Wisconsin, Madison: 08/2002 - Madison, Wisconsin, United States; Physics, Mathematics

MS from University of Wisconsin, Madison: 08/2004 - Madison, Wisconsin, United States; Biomedical Engineering

PhD from Oregon Health & Science University: 08/2010 - Portland, Oregon, United States; Neuroscience

Postdoctoral Fellowship at Yale University: 07/2015 - New Haven, Connecticut, United States; Neuroscience

Certifications

Assistant Professor: (08/01/2016); ��Ƶ of Medicine

Professional Interests

Neural mechanisms of auditory perception
Influence of brain state on perception and behavior
Neural mechanisms of perceptual cuing in decision making
Pupillometric measures, and neural correlates, of brain states and decisions
Neural mechanisms of perceptual enhancement with peripheral nerve stimulation

Professional Statement

Each moment, our senses are bombarded with information from many sources. How do networks of neurons in the brain rapidly process this information in order to make sense out of the world and choose appropriate actions? The McGinley lab approaches this question by studying neural mechanisms of auditory perceptual decision making behaviors, in mice. We primarily use whole-cell recording and two-photon imaging in head-fixed mice while they perform auditory perceptual decision-making tasks. The lab also utilizes computational and engineering approaches, optogenetics, multi-channel extracellular recording, pupillometry, and histological methods. We are currently focused on three related projects regarding the cellular, synaptic, and neuromodulatory mechanisms of auditory perceptual decision making: 1) Neuromodulatory mechanisms of attentional effort; 2) Improved perceptual learning with peripheral nerve stimulation; and 3) Brain circuits for navigation in acoustic virtual reality.

Websites

McGinley Lab website

Videos

McGinley et al. discover that cortical membrane potentials tightly track changes in arousal indicated by the pupil diameter. Additionally, arousal strongly influences performance on a detection task, revealing that hyperpolarized, quiescent cortical membrane potentials precede large, reliable sensory-evoked synaptic and action potentials during optimal states for behavior.

Selected Publications

McGinley MJ, David SV, and McCormick DA. " Cortical membrane potential signature of optimal states for sensory signal detection.. " Neuron. 2015 ; 87 : 179-192.
Wen H, Linhoff MW, McGinley MJ, Li GL, Corson GM, Mandel G, and Brehm P. " Distinct roles for two synaptotagmin isoforms in synchronous and asynchronous transmitter release at zebrafish neuromuscular junction.. " PNAS. 2010 ; 107(31) : 13906-11.
McGinley MJ, Liberman MC, Bal R, and Oertel D. " Generating synchrony from the asynchronous: compensation for cochlear traveling wave delays by the dendrites of individual brainstem neurons.. " J Neurosci. 2012 ; 32(27) : 9301-11.
McGinley MJ, and Westbrook GL. " Hierarchical excitatory synaptic connectivity in mouse olfactory cortex.. " PNAS. 2013 ; 110(40) : 16193-8.
Zagha E, Casale, AE, Sachdev RNS, McGinley MJ, and McCormick DA. " Motor cortex feedback influences sensory processing by modulating network state.. " Neuron. 2013 ; 79(3) : 567-78.
Hadzipasic M, Ni W, Nagy M, Steenrod N, McGinley MJ, Kaushal A, Thomas E, McCormick DA, and Horwitz AL. " Reduced high frequency motor neuron firing, EMG fractionation, and gait variability in awake walking ALS mice.. " 2016 ;
Reimer J*, McGinley MJ*, Liu Y, Rodenkirch C, Wang Q, McCormick DA, and Tolias A. " Pupil fluctuations track rapid changes in adrenergic and cholinergic activity in cortex.. " Nature Commun. 2016 ;
Tovar KR, McGinley MJ, and Westbrook GL. " Triheteromeric NMDA receptors at hippocampal synapses.. " J Neurosci. 2013 ; 33(21) : 9150-60.
McGinley MJ*, Vinck M*, Reimer J*, Batista-Brito R, Zagha E, Cadwell CR, Tolias AS, Cardin JA, McCormick DA. " Waking State: rapid variations modulate neural and behavioral responses.. " Neuron. 2015 ; 87(6) : 1143-61.

Memberships

Society for Neuroscience

Association for Research in Otolaryngology

Funding

Neuromodulatory Mechanisms of Listening Effort #R03DC015618: (08/01/2016 - 07/31/2019); Grant funding from National Institute of Deafness and Communication Disorders

Targeted Neuroplasticity Training: (01/01/2017 - 01/01/2021); Grant funding from Defense Advanced Research Projects Agency

Cain Foundation Laboratories: Gift funding from Cain Foundation

to edit your profile

������Ƶ