ÌÇÐÄÊÓƵ

Email

elz@bcm.edu

Positions

Kyle and Josephine Morrow Chair in Molecular Virology and Microbiology

Molecular Virology and Microbiology
ÌÇÐÄÊÓƵ of Medicine
Houston, TX, USA

Professor

Verna and Marrs McLean Department of Biochemistry & Molecular Pharmacology
ÌÇÐÄÊÓƵ of Medicine
Houston, Texas, United States

Member

Dan L Duncan Comprehensive Cancer Center
ÌÇÐÄÊÓƵ of Medicine
Houston, Texas, United States

Member

Dan L. Duncan Comprehensive Cancer Center

Education

Postdoctoral Training at University Of California, Berkeley

07/1997 - Berkeley, California, United States

Biophysics, Microbiology

PhD from Vanderbilt University

08/1990 - Nashville, Tennessee, United States

Biochemistry

BS from University Of Arkansas

05/1985 - Fayetteville, Arkansas, United States

Zoology, Math, Music

Honors & Awards

Elected Fellow

American Association for the Advancement of Science (11/2022)

Elected Fellow

National Academy of Inventors (12/2017)

Barbara and Corbin J. Robertson Jr. Presidential Award for Excellence in Education

"The Barbara and Corbin J. Robertson, Jr. Presidential Award for Excellence in Education emphasizes Baylor's commitment to education and recognizes the excellence in educational contributions of our faculty. The faculty who are honored with this prestigious award have shaped the lives of students through innovative teaching methods and mentoring to prepare our trainees to adopt the mantle of leadership regardless of the career path they choose. They represent the educational efforts of our entire faculty who excel in achieving the goals of our educational mission." Paul E. Klotman, M.D. President, CEO and Executive Dean, ÌÇÐÄÊÓƵ of Medicine

(05/2020)

Woman of Excellence

The Women of Excellence Award was established in 2018 to honor individuals who have demonstrated extraordinary dedication to issues that affect women at ÌÇÐÄÊÓƵ of Medicine or in the larger community and who exemplify Baylor values.

ÌÇÐÄÊÓƵ of Medicine (05/2018)

Human Frontier Science Program Research Grant

Human Frontier Science Program (07/2010 - 06/2014)

John S. Dunn Foundation Collaborative Research Award

John S. Dunn Foundation, Rice University and ÌÇÐÄÊÓƵ of Medicine (11/2011 - 10/2013)

Baylor Research Advocates for Student Scientists (BRASS) mentor of the year award

ÌÇÐÄÊÓƵ of Medicine (03/2013)

Applied Biosystems SOLiDTM 3 System $10K Genome Award

(02/2009)

Burroughs Wellcome Fund New Investigator Award in the Toxicological Sciences

Burroughs Wellcome Fund (07/1998 - 06/2002)

Professional Interests

• DNA supercoiling, DNA topoisomerases, antibiotic resistance, gene therapy

Websites

Selected Publications

• Vayssières M, Marechal N, Yun L, Lopez Duran B, Murugasamy NK, Fogg JM, Zechiedrich L, Nadal M, Lamour V. " " Science. 2024 Apr 12; 384 : 227-232.
  Pubmed PMID: .
• Radost Waszkiewicz, Maduni Ranasinghe, Jonathan M Fogg, Daniel J. Catanese, Jr., Maria L Ekiel-Jezewska, Maciej Lisicki, Borries Demeler, Lynn Zechiedrich, Piotr Szymczak. " " Nucleic Acids Res. 2023 ;
  Pubmed PMID: .
• Waszkiewicz R, Ranasinghe M, Fogg JM, Catanese DJ, Ekiel-Jeżewska ML, Lisicki M, Demeler B, Zechiedrich L, Szymczak P. " " Nucleic Acids Res. 2023 May 8; 51 (8) : 4027-4042.
  Pubmed PMID: .
• Chou A, Sucgang R, Hamill RJ, Zechiedrich L, Trautner BW. " " Access Microbiol. 2023 Feb 27; 5 (2) : acmi000421.
  Pubmed PMID: .
• Andrew Chou​​, Richard Sucgang​, Richard J. Hamill​, Lynn Zechiedrich, Barbara W. Trautner. " " Access Microbiol. 2023 Feb 27; 5 (2) : acmi000421.
  Pubmed PMID: .
• Maduni Ranasinghe, Jonathan M Fogg, Daniel J Catanese Jr, Lynn Zechiedrich, Borries Demeler. " " Eur Biophys J. 2023 Jul 27; DOI: 10.1007/s00249-023-01671-y
  Pubmed PMID: .
• Blunck BN, Angelo LS, Henke D, Avadhanula V, Cusick M, Ferlic-Stark L, Zechiedrich L, Gilbert BE, Piedra PA. " " Frontiers in Immunology. 2022 ; 13 : 823652.
  Pubmed PMID: .
• Jonathan M Fogg, Allison K Judge, Erik Stricker, Hilda L Chan, Lynn Zechiedrich. " " 2021 Sep ; 12 : 5683.
  Pubmed PMID: .
• Blunck BN, Aideyan L, Ye X, Avadhanula V, Ferlic-Stark L, Zechiedrich L, Gilbert BE, Piedra PA.. " " 2021 Feb ; 39 (8) : 1248-1256.
  Pubmed PMID: .
• Blunck BN, Aideyan L, Ye X, Avadhanula V, Ferlic-Stark L, Zechiedrich L, Gilbert BE, Piedra PA. " " 2021 Jan 24; 40 (3) : 536–543.
  Pubmed PMID: .
• Fogg, JM and Zechiedrich, L. " " 2020 ; 746 : 3–15.
• Arévalo-Soliz LM, Hardee CL, Fogg JM, Corman NR, Noorbakhsh C, Zechiedrich L.. " " 2020 Nov ; 6 (10) : 1489-1505.
  Pubmed PMID: .
• Fogg JM Zechiedrich L. " " Contemporary Mathematics—Topology and Geometry of Biopolymers. American Mathematical Society. 2020 ; 746 : 4–15.
• Zechiedrich L Fogg JM. " " J Tech Innov. 2019 ; 20 : 427-440.
• Zechiedrich L. " " Cell Gene Therapy Insights. 2019 Feb 4; 5 ((S1)) : 1–7.
• Conley ZC, Carlson-Banning KM, Carter AG, de la Cova A, Song Y, Zechiedrich L.. " " 2019 Jan 11; 1 : e0210547.
  Pubmed PMID: .
• Conley, ZC, Bodine, TJ, Chou, A, and Zechiedrich, L. " " PLOS Pathog.. 2018 Mar 1; 14 (3) : e1006805.
  Pubmed PMID: .
• Bizard AH, Yang X, Débat H, Fogg JM, Zechiedrich L, Strick TR, Garnier F, Nadal M. " " Nucleic Acids Res. 2018 Jan 25; 46 (2) : 861-872.
  Pubmed PMID: .
• Bodine TJ, Evangelista MA, Chang HT, Ayoub CA, Samuel BS, Sucgang R, Zechiedrich L. " " 2017 Jul 11; 12 : e0180800.
  Pubmed PMID: .
• Wang Q, Irobalieva RN, Chiu W, Schmid MF, Fogg JM, Zechiedrich L, Pettitt BM. " " 2017 Jul 27; 45 : 7633-7642.
  Pubmed PMID: .
• Hardee CL, Arévalo-Soliz LM, Hornstein BD, Zechiedrich L. " " 2017 Feb 10; 8 : pii: E65.
  Pubmed PMID: .
• Chou A, Roa M, Evangelista MA, Sulit AK, Lagamayo E, Torres BC, Klinzing DC, Daroy ML, Navoa-Ng J, Sucgang R, Zechiedrich L. " " 2016 Oct ; 22 : 585-588.
  Pubmed PMID: .
• Hornstein BD, Roman D, Arévalo-Soliz LM, Engevik MA, Zechiedrich L. " " 2016 Dec 5; 11 : e0167537.
  Pubmed PMID: .
• Bates D, Pettitt BM, Buck GR, Zechiedrich L. " " 2016 Sep ; 18 : 160-164.
  Pubmed PMID: .
• Koire A, Gilbert BE, Sucgang R, Zechiedrich L. " " 2016 Oct 27; 11 : e0165729.
  Pubmed PMID: .
• Chou A, Nuila RE, Franco LM, Stager CE, Atmar RL, Zechiedrich L. " " 2016 Sep ; 65 : 1047-8.
  Pubmed PMID: .
• Pandey N, Nobles CL, Zechiedrich L, Maresso AW, Silberg JJ. " " 2015 May 15; 4 : 615-24.
  Pubmed PMID: .
• Irobalieva RN, Fogg JM, Catanese DJ Jr, Sutthibutpong T, Chen M, Barker AK, Ludtke SJ, Harris SA, Schmid MF, Chiu W, Zechiedrich L. " " 2015 Oct 12; 6 : 8440.
  Pubmed PMID: .
• Carlson-Banning, KM and Zechiedrich, L. " Antibiotic classes and mechanisms of resistance—considerations for future antibiotic development.. " Encyclopedia of Metagenomics. 2014 ;
• Carlson-Banning KM, Chou A, Liu Z, Hamill RJ, Song Y, Zechiedrich L. " " 2013 Jul 23; 8 : e69646.
  Pubmed PMID: .
• Swick MC, Evangelista MA, Bodine TJ, Easton-Marks JR, Barth P, Shah MJ, Bormann Chung CA, Stanley S, McLaughlin SF, Lee CC, Sheth V, Doan Q, Hamill RJ, Steffen D, Becnel LB, Sucgang R, Zechiedrich L. " " 2013 Jun 18; 8 : e65961.
  Pubmed PMID: .
• Fogg JM, Randall GL, Pettitt BM, Sumners de WL, Harris SA, Zechiedrich L. " " Q. Rev. Biophys.. 2012 Aug ; 45 (3) : 257-99.
  Pubmed PMID: .
• Zechiedrich L. " " Int. J. Urol.. 2012 Apr ; 19 (4) : 368-9.
  Pubmed PMID: .
• Singh R, Swick MC, Ledesma KR, Yang Z, Hu M, Zechiedrich L, Tam VH. " " Antimicrob. Agents Chemother.. 2012 Apr ; 56 (4) : 1680-5.
  Pubmed PMID: .
• Catanese DJ, Fogg JM, Schrock DE, Gilbert BE, Zechiedrich L. " " Gene Ther.. 2012 Jan ; 19 (1) : 94-100.
  Pubmed PMID: .
• Zhao N, Fogg JM, Zechiedrich L, Zu Y. " " Gene Ther.. 2011 Mar ; 18 (3) : 220-4.
  Pubmed PMID: .
• Swick MC, Morgan-Linnell SK, Carlson KM, Zechiedrich L. " " Antimicrob. Agents Chemother.. 2011 Feb ; 55 (2) : 921-4.
  Pubmed PMID: .
• Liu Z, Zechiedrich L, Chan HS. " " J. Mol. Biol.. 2010 Jul 30; 400 (5) : 963-82.
  Pubmed PMID: .
• Zechiedrich L, Osheroff N. " " Structure. 2010 Jun 9; 18 (6) : 661-3.
  Pubmed PMID: .
• Liu Z, Zechiedrich L, Chan HS. " " Phys Rev E Stat Nonlin Soft Matter Phys. 2010 Mar ; 81 (3) : 31902.
  Pubmed PMID: .
• Randall GL, Zechiedrich L, Pettitt BM. " " Nucleic Acids Res.. 2009 Sep ; 37 (16) : 5568-77.
  Pubmed PMID: .
• Liu Z, Deibler RW, Chan HS, Zechiedrich L. " " Nucleic Acids Res.. 2009 Feb ; 37 (3) : 661-71.
  Pubmed PMID: .
• Morgan-Linnell SK, Becnel Boyd L, Steffen D, Zechiedrich L. " " Antimicrob. Agents Chemother.. 2009 Jan ; 53 (1) : 235-41.
  Pubmed PMID: .
• Becnel Boyd L, Maynard MJ, Morgan-Linnell SK, Horton LB, Sucgang R, Hamill RJ, Jimenez JR, Versalovic J, Steffen D, Zechiedrich L. " " Antimicrob. Agents Chemother.. 2009 Jan ; 53 (1) : 229-34.
  Pubmed PMID: .
• Boyd LB, Atmar RL, Randall GL, Hamill RJ, Steffen D, Zechiedrich L. " " BMC Infect. Dis.. 2008 ; 8 : 4.
  Pubmed PMID: .
• Morgan-Linnell SK, Hiasa H, Zechiedrich L, Nitiss JL. " " Curr Protoc Pharmacol. 2007 Dec ; Unit3.13.
  Pubmed PMID: .
• Morgan-Linnell SK, Zechiedrich L. " " Antimicrob. Agents Chemother.. 2007 Nov ; 51 (11) : 4205-8.
  Pubmed PMID: .
• Deibler RW, Mann JK, Sumners de WL, Zechiedrich L. " " BMC Mol. Biol.. 2007 ; 8 : 44.
  Pubmed PMID: .
• Liu Z, Mann JK, Zechiedrich EL, Chan HS. " " J. Mol. Biol.. 2006 Aug 11; 361 (2) : 268-85.
  Pubmed PMID: .
• Randall GL, Pettitt BM, Buck GR, Zechiedrich EL. " " J Phys Condens Matter. 2006 Apr 12; 18 (14) : S173-S185.
  Pubmed PMID: .
• Fogg JM, Kolmakova N, Rees I, Magonov S, Hansma H, Perona JJ, Zechiedrich EL. " " J Phys Condens Matter. 2006 Apr 12; 18 (14) : S145-S159.
  Pubmed PMID: .
• Liu Z, Zechiedrich EL, Chan HS. " " Biophys. J.. 2006 Apr 1; 90 (7) : 2344-55.
  Pubmed PMID: .
• Yang S, Lopez CR, Zechiedrich EL. " " Proc. Natl. Acad. Sci. U.S.A.. 2006 Feb 14; 103 (7) : 2386-91.
  Pubmed PMID: .
• Lopez CR, Yang S, Deibler RW, Ray SA, Pennington JM, Digate RJ, Hastings PJ, Rosenberg SM, Zechiedrich EL. " " Mol. Microbiol.. 2005 Oct ; 58 (1) : 80-101.
  Pubmed PMID: .
• Gruger T, Nitiss JL, Maxwell A, Zechiedrich EL, Heisig P, Seeber S, Pommier Y, Strumberg D. " " Antimicrob. Agents Chemother.. 2004 Dec ; 48 (12) : 4495-504.
  Pubmed PMID: .
• Buck GR, Zechiedrich EL. " " J. Mol. Biol.. 2004 Jul 23; 340 (5) : 933-9.
  Pubmed PMID: .
• Yang S, Clayton SR, Zechiedrich EL. " " J. Antimicrob. Chemother.. 2003 Mar ; 51 (3) : 545-56.
  Pubmed PMID: .
• Rahmati S, Yang S, Davidson AL, Zechiedrich EL. " " Mol. Microbiol.. 2002 Feb ; 43 (3) : 677-85.
  Pubmed PMID: .
• Deibler RW, Rahmati S, Zechiedrich EL. " " Genes Dev.. 2001 Mar 15; 15 (6) : 748-61.
  Pubmed PMID: .
• Zechiedrich EL, Khodursky AB, Bachellier S, Schneider R, Chen D, Lilley DM, Cozzarelli NR. " " J. Biol. Chem.. 2000 Mar 17; 275 (11) : 8103-13.
  Pubmed PMID: .
• Zechiedrich EL, Crisona NJ. " " Methods Mol. Biol.. 1999 ; 94 : 99-107.
  Pubmed PMID: .
• Zechiedrich EL, Khodursky AB, Cozzarelli NR. " " Genes Dev.. 1997 Oct 1; 11 (19) : 2580-92.
  Pubmed PMID: .
• Khodursky AB, Zechiedrich EL, Cozzarelli NR. " " Proc. Natl. Acad. Sci. U.S.A.. 1995 Dec 5; 92 (25) : 11801-5.
  Pubmed PMID: .
• Zechiedrich EL, Cozzarelli NR. " " Genes Dev.. 1995 Nov 15; 9 (22) : 2859-69.
  Pubmed PMID: .
• Crisona NJ, Kanaar R, Gonzalez TN, Zechiedrich EL, Klippel A, Cozzarelli NR. " " J. Mol. Biol.. 1994 Oct 28; 243 (3) : 437-57.
  Pubmed PMID: .
• Adams DE, Shekhtman EM, Zechiedrich EL, Schmid MB, Cozzarelli NR. " " Cell. 1992 Oct 16; 71 (2) : 277-88.
  Pubmed PMID: .
• Corbett AH, Zechiedrich EL, Osheroff N. " " J. Biol. Chem.. 1992 Jan 15; 267 (2) : 683-6.
  Pubmed PMID: .
• Corbett AH, Zechiedrich EL, Lloyd RS, Osheroff N. " " J. Biol. Chem.. 1991 Oct 15; 266 (29) : 19666-71.
  Pubmed PMID: .
• Osheroff N, Zechiedrich EL, Gale KC. " " Bioessays. 1991 Jun ; 13 (6) : 269-73.
  Pubmed PMID: .
• Zechiedrich EL, Osheroff N. " " EMBO J.. 1990 Dec ; 9 (13) : 4555-62.
  Pubmed PMID: .
• Andersen AH, Christiansen K, Zechiedrich EL, Jensen PS, Osheroff N, Westergaard O. " " Biochemistry. 1989 Jul 25; 28 (15) : 6237-44.
  Pubmed PMID: .
• Zechiedrich EL, Christiansen K, Andersen AH, Westergaard O, Osheroff N. " " Biochemistry. 1989 Jul 25; 28 (15) : 6229-36.
  Pubmed PMID: .
• Osheroff N, Zechiedrich EL. " " Biochemistry. 1987 Jul 14; 26 (14) : 4303-9.
  Pubmed PMID: .
• Richman DE, Wendorff TJ, Rashid F, Beck C, Yan Q, Johnson HR, Eckerty RA, Fogg JM, Baker ML, Zechiedrich L, Berger JM. " " Nature Communications. 2026 ; in press
  Pubmed PMID: .

Show 70 more publications

Memberships

Biophysical Society

Member (01/2017 - 12/2033)

American Society For Microbiology

Member (08/1997)

American Association for the Advancement of Science

Member (01/1996 - 01/2012)

American Association for the Advancement of Science

Member (12/2017 - 12/2033)

American Society for Biochemistry and Molecular Biology

Member (01/1996 - 12/2032)

American Society for Cell Biology

Member (01/2007 - 01/2010)

American Chemical Society

Member (01/2001 - 01/2010)

American Mathematical Society

Member (01/1999 - 12/2033)

American Society for Microbiology, Texas Branch

Member (01/1997 - 12/2033)

Funding

Harnessing Supercoiling to Regulate DNA Activity
#R35 GM141793

(10/01/2021 - 09/30/2026)

Grant funding from National Institutes of Health

DNA Damage Recognition in Linear and Supercoiled DNA
#MCB 2107527

(04/01/2021 - 03/31/2025)

Grant funding from National Science Foundation