John P Lydon

John P Lydon, Ph.D.

Associate Professor

Email

jlydon@bcm.edu

Positions

Associate Professor: Mol & Cell Biology-O'Malley
��Ƶ of Medicine
Houston, TX, US

Member: Dan L Duncan Comprehensive Cancer Center
��Ƶ of Medicine
Houston, Texas, United States

Professional Interests

Steroid receptor and coregulator control of normal and abnormal functions of the uterus and mammary gland.

Professional Statement

Our research group is interested in understanding the cellular and molecular signaling mechanisms by which steroid hormone receptors and their coregulators control the biology and pathobiology of the female reproductive tract and mammary gland. One of our research projects is focused on delineating the role of progesterone receptor mediated signaling in the development of uterine receptivity, an endometrial transient state that is necessary for embryo implantation and pregnancy establishment. Another research focus is to elucidate the involvement of progesterone signaling in postnatal mammary gland development and tumorigenesis, currently a controversial and poorly understood area of breast cancer investigation. Our final—and more recent—research focus is to determine the molecular underpinnings that initiate and promote salivary gland malignancies, an understudied but lethal subset of head and neck cancers. Along with the use of state-of-the-art engineered mouse models, inventive cellular and molecular investigative approaches, and genome-wide analytics, we routinely collaborate with our clinical colleagues to translate our findings from both cell culture and mouse studies to the human. Because of the research questions being addressed in our laboratory, results from our studies have the potential to significantly advance our clinical understanding of female infertility as well as the etiopathogenesis of select exocrine tissue cancers, such as those of the mammary and salivary gland.

Websites

Selected Publications

Fernandez-Valdivia R, Jeong J, Mukherjee A, Soyal SM, Li J, Ying Y, Demayo FJ, Lydon JP. " " Genesis. 2010 Feb ; 48 (2) : 106-13.
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Mukherjee A, Soyal SM, Li J, Ying Y, Szwarc MM, He B, Kommagani R, Hodgson MC, Hiremath M, Cowin P, Lydon JP. " " Transgenic Res.. 2011 Aug ; 20 (4) : 827-40.
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Ismail PM, Li J, DeMayo FJ, O'Malley BW, Lydon JP. " " Mol. Endocrinol.. 2002 Nov ; 16 (11) : 2475-89.
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Soyal SM, Mukherjee A, Lee KY, Li J, Li H, DeMayo FJ, Lydon JP. " " Genesis. 2005 Feb ; 41 (2) : 58-66.
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Lydon JP, Edwards DP. " " Endocrinology. 2009 Jul ; 150 (7) : 2988-90.
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Fernandez-Valdivia R, Lydon JP. " " Mol. Cell. Endocrinol.. 2012 Jun 24; 357 (41276) : 91-100.
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Lydon JP, DeMayo FJ, Funk CR, Mani SK, Hughes AR, Montgomery CA, Shyamala G, Conneely OM, O'Malley BW. " " Genes Dev.. 1995 Sep 15; 9 (18) : 2266-78.
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Lydon JP. " " Nature. 2010 Jun 10; 465 (7299) : 695-6.
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Mukherjee A, Soyal SM, Li J, Ying Y, He B, DeMayo FJ, Lydon JP. " " FASEB J.. 2010 Nov ; 24 (11) : 4408-19.
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Mukherjee A, Soyal SM, Fernandez-Valdivia R, DeMayo FJ, Lydon JP. " " Genesis. 2007 Oct ; 45 (10) : 639-46.
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Mukherjee A, Soyal SM, Wheeler DA, Fernandez-Valdivia R, Nguyen J, DeMayo FJ, Lydon JP. " " Genesis. 2006 Dec ; 44 (12) : 601-10.
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Fernandez-Valdivia R, Mukherjee A, Ying Y, Li J, Paquet M, DeMayo FJ, Lydon JP. " " Dev. Biol.. 2009 Apr 1; 328 (1) : 127-39.
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Fernandez-Valdivia R, Mukherjee A, Creighton CJ, Buser AC, DeMayo FJ, Edwards DP, Lydon JP. " " Endocrinology. 2008 Dec ; 149 (12) : 6236-50.
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Kommagani R, Szwarc MM, Vasquez YM, Peavey MC, Mazur EC, Gibbons WE, Lanz RB, DeMayo FJ, Lydon JP. " " PLoS Genet.. 2016 Apr 1; 12 (4)
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Kommagani R, Szwarc MM, Kovanci E, Creighton CJ, O'Malley BW, DeMayo FJ, Lydon JP. " " Biol Reprod.. 2014 Apr 10; 90 (4)
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Kommagani R, Szwarc MM, Kovanci E, Gibbons WE, Putluri N, Maity S, Creighton CJ, Sreekumar A, DeMayo FJ, Lydon JP, O'Malley BW. " " PLoS Genet.. 2013 Oct 9; 10
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Szwarc MM, Kommagani R, Lessey BA, Lydon JP. " " Biol Reprod.. 2014 Nov ; 91 (5)
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Fernandez-Valdivia R, Mukherjee A, Creighton CJ, Buser AC, DeMayo FJ, Edwards DP, Lydon JP.. " " Endocrinology. 2008 Dec ; 149 (12) : 6236-50.
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Hai L, Szwarc MM, Lonard DM, Rajapakshe K, Perera D, Coarfa C, Ittmann M, Fernandez-Valdivia R, and Lydon JP. " " Cytokine. 2019 Jun 18; 18 (123) : 154745-.
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Szwarc MM, Hai L, Gibbons WE, Mo Q, Lanz RB, DeMayo FJ, Lydon JP. " " Journal of Steroid Biochemistry and Molecular Biology. 2019 Jan 31; 189 : 282-290.
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Hai L, Szwarc MM. He B, Lonard DM, Kommagani R, DeMayo FJ, Lydon JP. " " Biology of Reproduction. 2018 Jun 1; 98 (6) : 856-869.
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Hai L, Szwarc MM, Lanza DG, Heanet JD, Lydon JP. " " Genesis. 2019 Mar ; 57 (3)
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Szwarc MM, Kommagani R, Putluri V, Dubrulle J, Stossi F, Mancini MA, Coarfa C, Lanz RB, Putluri N, DeMayo FJ, Lydon JP, O'Malley BW. " " Scientific Reports. 2018 Sep 3; 8 (1)
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Wang X, Li X, Wang T, Wu SP, Jeong JW, Kim TH, Young SL, Lessy BA, Lanz RB, Lydon JP, DeMayo FJ. " " Nature Communications. 2018 Oct 24; 9 (1)
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Szwarc MM, Hai L, Gibbons WE, White LD, Mo Q, Kommagani R, Lanz RB, DeMayo FJ, O'Malley BW, Lydon JP. " " Reproduction. 2018 Oct 16; 156 (5) : 387-395.
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Szwarc MM, Hai L, Gibbons WE, Peavey MC, White LD, Mo Q, LOnard DM, Kommagani R, Lanz RB, DeMayo FJ, Lydon JP. " " Biology of Reproduction. 2018 Jan 1; 98 (1) : 15-27.
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Vasquez YM, Wang X, Wetendorf M, Franco HL, Mo Q, Wang T, Lanz RB, Young SL, Lessy BA, Spencer TE, Lydon JP, DeMayo FJ. " " PLoS Genetics. 2018 Nov 20; 14 (11)
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Hai L, Szwarc MM, Wetendorf M, Wu SP, Peavey MC, Grimm SL, Edwards DP, DeMayo FJ, Lydon JP. " " Genesis. 2018 Aug 10; 56 (8)
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Peavey MC, Reynolds CL, Szwarc MM, Gibbons WE, Valdes CT, DeMayo FJ, Lydon JP. " " Journal of Visual Expression. 2017 Oct 24; 128
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Szwarc MM, Kommagani R, Peavey MC, Hai L, Lonard DM, Lydon JP. " " PLoS One. 2017 Mar 2; 12 (3)
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Peavey MC, Reynolds CL, Szwarc MM, Gibbons WE, Valdes CT, DeMayo FJ, Lydon JP. " " PLoS One. 2017 Jan 3; 12 (1)
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Rubel CA, Wu SP, Lin L, Wang T, Lanz RB, Li X, Kommagani R, Franco HL, Camper SA, Tong Q, Jeong JW, Lydon JP, DeMayo FJ. " " Cell Reports. 2016 Oct 25; 17 (5) : 1414-1425.
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Szwarc MM, Lydon JP, O'Malley BW. " " Journal of Steroid Biochemistry and Molecular Biology. 2015 Nov ; 154 : 32-38.
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Szwarc MM, Kommagani R, Jacob AP, Dougall WC, Ittmann MM, Lydon JP. " " PLoS. 2015 Jun 10; 10 (6)
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Szwarc MM, Kommagani R, Jeong JW, Wu SP, Tsai SY, Tsai MJ, O'Malley BW, DeMayo FJ, Lydon JP. " " PLoS One. 2014 Jun 6; 9 (6)
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