Jianming Xu

Jianming Xu, Ph.D.

Gordon Cain Endowed Professorship in Cell Biology

(713) 798-6199

Email

jxu@bcm.edu

Positions

Gordon Cain Endowed Professorship in Cell Biology: Mol & Cell Biology-Xu
��Ƶ of Medicine
Houston, TX, US

Addresses

Gordon Cain Endowed Professorship in Cell Biology, Department of Molecular and Cellular Biology; Director of the Genetically Engineered Mouse Core, ��Ƶ of Medicine (Office): One Baylor Plaza, Alkek Building, Room N630.03
Houston, TX, 77030
United States

Education

PhD from Clarkson University/W. Alton Johns Cell Science Center: 05/1994 - Potsdam, NY, United States

Postdoctoral Training at ��Ƶ Of Medicine: 10/1997 - Houston, TX, United States

Professional Interests

Gene networks & signaling pathways that regulate steroid hormone-promoted cancers

Professional Statement

Overexposure and/or super sensitiveness to sex steroid hormones, such as estrogen and androgen, are risk factors that promote breast, endometrial and prostate carcinogenesis. Because of the high incidences and mortality, these steroid-promoted cancers remain to be a major threat to human health. Steroid receptors are transcription factors that depend on their coregulators to regulate specific gene expression. Each receptor can work with multiple coregulators and each coregulators also can work with multiple receptors and other types of transcription factors to regulate gene expression. In turn, these gene products are involved in various signaling pathways that control initiation, progression and metastasis of these steroid promoted cancers. Our research is mainly focused on determining the oncogenic or tumor-suppressive roles of a group of coregulators altered in breast, prostate or endometrial cancers and elucidating their molecular mechanisms for regulating the initiation, progression and metastasis of these cancers. Our ultimate goal is to identify cancer type-specific targets and pathways for the cure of steroid-promoted cancers.

Our lab is adequately equipped to execute multidisciplinary, complex studies from a single molecule to an entire mouse. In addition to common molecular, cellular and animal approaches, we routinely use many advanced technologies in our research, such as gene expression profiling, ChIP-Seq, whole genome sequencing, metabolomic profiling, Co-IP/mass spectrometry, gene knock-down/knockout/knock-in in various cell lines or mice, generation and staining of micro tissue arrays, and various kinds of xenograft/transgenic mouse models of human cancers. We have many years of experience on generating and characterization of genetically engineered mouse models.

Up to date, Dr. Xu has published ~160 peer-reviewed articles and trained 32 postdocs and 11 graduate students.

Websites

Selected Publications

Xu J, Liao L, Ning G, Yoshida-Komiya H, Deng C, O'Malley BW. " " Proc. Natl. Acad. Sci. U.S.A.. 2000 Jun 6; 97 (12) : 6379-84.
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Qin L, Liu Z, Chen H, Xu J. " " Cancer Res.. 2009 May 1; 69 (9) : 3819-27.
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Fu J, Qin L, He T, Qin J, Hong J, Wong J, Liao L, Xu J. " " Cell Res.. 2011 Feb ; 21 (2) : 275-89.
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Qin L, Liao L, Redmond A, Young L, Yuan Y, Chen H, O'Malley BW, Xu J. " " Mol. Cell. Biol.. 2008 Oct ; 28 (19) : 5937-50.
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Qin L, Chen X, Wu Y, Feng Z, He T, Wang L, Liao L, Xu J. " " Cancer Res.. 2011 Mar 1; 71 (5) : 1742-51.
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Hong J, Zhou J, Fu J, He T, Qin J, Wang L, Liao L, Xu J. " " Cancer Res.. 2011 Jun 1; 71 (11) : 3980-90.
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Mark M, Yoshida-Komiya H, Gehin M, Liao L, Tsai MJ, O'Malley BW, Chambon P, Xu J. " " Proc. Natl. Acad. Sci. U.S.A.. 2004 Mar 30; 101 (13) : 4453-8.
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Xu J, Qiu Y, DeMayo FJ, Tsai SY, Tsai MJ, O'Malley BW. " " Science. 1998 Mar 20; 279 (5358) : 1922-5.
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Qin Q, Xu Y, He T, Qin C, Xu J. " " Cell Res.. 2012 Jan ; 22 (1) : 90-106.
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Xu J, Wu RC, O'Malley BW. " " Nat. Rev. Cancer. 2009 Sep ; 9 (9) : 615-30.
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Kuang SQ, Liao L, Wang S, Medina D, O'Malley BW, Xu J. " " Cancer Res.. 2005 Sep 1; 65 (17) : 7993-8002.
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Liu Z, Zhou S, Liao L, Chen X, Meistrich M, Xu J. " " J. Biol. Chem.. 2010 Jan 22; 285 (4) : 2758-70.
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Zhang H, Kuang SQ, Liao L, Zhou S, Xu J. " " Cancer Res.. 2004 Oct 1; 64 (19) : 7169-77.
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Yuan Y, Qin L, Liu D, Wu RC, Mussi P, Zhou S, Songyang Z, Xu J. " " Cancer Res.. 2007 Sep 1; 67 (17) : 8032-42.
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Chung AC, Zhou S, Liao L, Tien JC, Greenberg NM, Xu J. " " Cancer Res.. 2007 Jun 15; 67 (12) : 5965-75.
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Wang S, Yuan Y, Liao L, Kuang SQ, Tien JC, O'Malley BW, Xu J. " " Proc. Natl. Acad. Sci. U.S.A.. 2009 Jan 6; 106 (1) : 151-6.
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Kuang SQ, Liao L, Zhang H, Pereira FA, Yuan Y, DeMayo FJ, Ko L, Xu J. " " J. Biol. Chem.. 2002 Nov 22; 277 (47) : 45356-60.
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Kuang SQ, Liao L, Zhang H, Lee AV, O'Malley BW, Xu J. " " Cancer Res.. 2004 Mar 1; 64 (5) : 1875-85.
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Chen X, Liu Z, Xu J. " " Mol. Endocrinol.. 2010 Oct ; 24 (10) : 1917-34.
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Yuan Y, Liao L, Tulis DA, Xu J. " " Circulation. 2002 Jun 4; 105 (22) : 2653-9.
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Li Q, Chu MJ, Xu J. " " Mol. Cell. Biol.. 2007 Dec ; 27 (23) : 8073-86.
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Xu J, Nawaz Z, Tsai SY, Tsai MJ, O'Malley BW. " " Proc. Natl. Acad. Sci. U.S.A.. 1996 Oct 29; 93 (22) : 12195-9.
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Louet JF, Chopra AR, Sagen JV, An J, York B, Tannour-Louet M, Saha PK, Stevens RD, Wenner BR, Ilkayeva OR, Bain JR, Zhou S, DeMayo F, Xu J, Newgard CB, O'Malley BW. " " Cell Metab.. 2010 Dec 1; 12 (6) : 606-18.
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Liao L, Dearth RK, Zhou S, Britton OL, Lee AV, Xu J. " " Endocrinology. 2006 Aug ; 147 (8) : 3877-88.
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Weiss RE#, Xu J#, Ning G, Pohlenz J, O’Malley BW, and Refetoff S. " Mice deficient in the steroid receptor coactivator-1 (SRC-1) are resistant to thyroid hormone. " EMBO J. 1999 ; 18 : 1900-4.
Puigserver P, Adelmant G, Wu Z, Fan M, Xu J, O'Malley B, Spiegelman BM. " " Science. 1999 Nov 12; 286 (5443) : 1368-71.
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Nishihara E, Yoshida-Komiya H, Chan CS, Liao L, Davis RL, O'Malley BW, Xu J. " " J. Neurosci.. 2003 Jan 1; 23 (1) : 213-22.
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Zhang H, Liao L, Kuang SQ, Xu J. " " Endocrinology. 2003 Apr ; 144 (4) : 1435-43.
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Xu J, Li Q. " " Mol. Endocrinol.. 2003 Sep ; 17 (9) : 1681-92.
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Mussi P, Yu C, O'Malley BW, Xu J. " " Mol. Endocrinol.. 2006 Dec ; 20 (12) : 3105-19.
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Mussi P, Liao L, Park SE, Ciana P, Maggi A, Katzenellenbogen BS, Xu J, O'Malley BW. " " Proc. Natl. Acad. Sci. U.S.A.. 2006 Nov 7; 103 (45) : 16716-21.
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Yu C, York B, Wang S, Feng Q, Xu J, O'Malley BW. " " Mol. Cell. 2007 Mar 9; 25 (5) : 765-78.
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Yuan Y, Xu J. " " Arterioscler. Thromb. Vasc. Biol.. 2007 Jul ; 27 (7) : 1521-7.
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Liao L, Chen X, Wang S, Parlow AF, Xu J. " " Mol. Cell. Biol.. 2008 Apr ; 28 (7) : 2460-9.
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Liu Z, Liao L, Zhou S, Xu J. " " Int. J. Biol. Sci.. 2008 ; 4 (4) : 202-7.
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Chopra AR, Louet JF, Saha P, An J, Demayo F, Xu J, York B, Karpen S, Finegold M, Moore D, Chan L, Newgard CB, O'Malley BW. " " Science. 2008 Nov 28; 322 (5906) : 1395-9.
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York B, Yu C, Sagen JV, Liu Z, Nikolai BC, Wu RC, Finegold M, Xu J, O'Malley BW. " " Proc. Natl. Acad. Sci. U.S.A.. 2010 Jun 15; 107 (24) : 11122-7.
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York B, Reineke EL, Sagen JV, Nikolai BC, Zhou S, Louet JF, Chopra AR, Chen X, Reed G, Noebels J, Adesina AM, Yu H, Wong LJ, Tsimelzon A, Hilsenbeck S, Stevens RD, Wenner BR, Ilkayeva O, Xu J, Newgard CB, O’Malley BW. " Ablation of steroid receptor coactivator-3 resembles the human CACT metabolic myopathy. " Cell Metab. 2012 ; 15 (5) : 752-63.
Zhou J, Qin L, Gao L, Chen X, Tien JCY, Wang F, Hsieh J-T, Xu J. " Nkx3.1 functions as a “Para-Transcription Factor” to regulate gene expression and cell proliferation in a non-cell-autonomous manner. " J Biol Chem. 2012 ; 287 : 17248-56.
Chen LY, Zhang Y, Zhang Q, Li H, Luo Z, Fang H, Kim SH, Qin L, Yotnda P, Xu J, Tu BP, Bai Y, Songyang Z. " Mitochondrial localization of telomeric protein TIN2 links telomere regulation to metabolic control. " Mol Cell. 2012 ; 47 (6) : 839-50.
Kawagoe J, Li Q, Mussi P, Liao L, Lydon JP, DeMayo FJ and Xu J. " Nuclear receptor coactivator-6 attenuates uterine estrogen sensitivity to permit embryo implantation. " Dev Cell. 2012 ; 23 : 858-65.
Tien JC, Liu Z, Liao L, Wang F, Xu Y, Wu YL, Zhou N, Ittmann M, Xu J. " The steroid receptor coactivator-3 is required for the development of castration-resistant prostate cancer. " Cancer Res. 2013 ; 73 (13) : 3997-4008.
Xu Y, Xu Y, Liao L, Zhou Z, Theissen S, Liao X-H, Nguyen H, Ludwig T, Qin L, Martinez J, Jiang J, Xu J. " Inducible knockout of Twist1 in young and adult mice prolongs hair growth cycle and has mild effects on general health, supporting Twist1 as a preferential cancer target. " Am J Pathol. 2013 ; 183 (4) : 1281-92.
Wang Y, Lonard DM, Yu Y, Chow DC, Palzkill TG, Wang J, Qi R, Matzuk AJ, Song X, Madoux F, Hodder P, Chase P, Griffin PR, Zhou S, Liao L, Xu J, O'Malley BW. " Bufalin Is a Potent Small-Molecule Inhibitor of the Steroid Receptor Coactivators SRC-3 and SRC-1. " Cancer Res. 2014 ; 74 (5) : 1506-17.
Qin L, Wu YL, Toneff MJ, Li D, Liao L, Gao X, Bane FT, Tien J, Xu Y, Feng Z, Yang Z, Xu Y, Theissen SM, Li Y, Young L, Xu J. " NCOA1 directly targets M-CSF1 expression to promote breast cancer metastasis. " Cancer Res. 2014 ; 74 : 3477-88.
Lee DK, Liu Y, Liao L, Wang F, Xu J. " The prostate basal cell (BC) heterogeneity and the p63-positive BC differentiation spectrum in mice. " Int J Biol Sci. 2014 ; 10 (9) : 1007-17.
Tien J, Liao L, Liu Y, Liu Z, Lee DK, Wang F, Xu J. " The steroid receptor coactivator-3 is required for developing neuroendocrine tumor in mice. " Int J Biol Sci. 2014 ; 10 (10) : 1116-27.
Ma G, He J, Yu Y, Xu Y, Yu X, Martinez J, Lonard DM, Xu J. " Tamoxifen Inhibits ER-negative Breast Cancer Cell Invasion and Metastasis by Accelerating Twist1 Degradation. " Int J Biol Sci. 2015 ; 11 (5) : 618-28.
Wang L, Yu Y, Chow DC, Yan F, Hsu CC, Stossi F, Mancini MA, Palzkill T, Liao L, Zhou S, Xu J, Lonard DM, O’Malley BW. " Overactivation of the p160 SRCs by the small molecular inhibitor MCB-613 causes cancer cell stress and paraptosis. " Cancer Cell. 2015 ; 28 (2) : 240-52.
Gao L, Rabbitt EH, Condon JC, Renthal NE, Mitsche MA, Chambon P, Xu J, O’Malley BW, Mendelson CR. " Steroid receptor coactivators 1 and 2 mediate fetal-to-maternal signaling that initiates parturition. " J Clin Invest. 2015 ; 125 (7) : 2808-24.
Qin L, Xu Y, Xu Y, Ma G, Liao L, Wu Y, Li Y, Wang X, Wang X, Jiang J, Wang J, Xu J. " NCOA1 Promotes Angiogenesis in Breast Tumors by Simultaneously Enhancing both HIF1α- and AP-1-mediated VEGFa Transcription. " Oncotarget. 2015 ; 6 (27) : 11518-28.
Sun T, Fu J, Shen T, Lin X, Liao L, Feng XH, Xu J. " The small C-terminal domain phosphatase 1 inhibits cancer cell migration and invasion by dephosphorylating phospho-Ser68-Twist1 to accelerate Twist1 degradation. " J Biol Chem. 2015 ; 291 (22) : 11518-28.
Song X, Chen J, Zhao M, Zhang C, Yu Y, Lonard DM, Chow DC, Palzkill T, Xu J, O’Malley BW, Wang J. " Development of potent small-molecular inhibitors to drug the undruggable steroid receptor coactivator-3. " Proc Natl Acad Sci USA. 2016 ; 113 (18) : 4970-5.
Welte T, Kim IS, Tian L, Gao X, Wang H, Li J, Holdman XB, Herschkowitz JI, Pond A, Xie G, Kurley S, Nguyen T, Liao L, Dobrolecki LE, Pang L, Mo Q, Edwards DP, Huang S, Xin L, Xu J, Li Y, Lewis MT, Wang T, Westbrook TF, Rosen JM, Zhang XH. " Oncogenic mTOR signaling recruits myeloid-derived suppressor cells to promote tumour initiation. " Nat Cell Biol. 2016 ; 18 (6) : 632-44.
Xu Y, Qin L, Sun T, Wu H, He T, Yang Z, Mo Q, Liao L, Xu J. " Twist1 Promotes Breast Cancer Invasion and Metastasis by Silencing Foxa1 Expression. Oncogene. " Oncogene. 2016 ; 36 (8) : 1157-66.
Shi E, Kan M, Xu JM, McKeehan WL. " " J. Biol. Chem.. 1991 Mar 25; 266 (9) : 5774-9.
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Yu X, Xu J. " A “goldmine” for digging cancer-specific targets: the genes essential for embryonic development but nonessential for adult life. " J Mol Cell Biol. 2020 ; 12 (9) : 669-73.
Kruse RL, Barzi M, Legras X, Pankowicz FP, Furey N, Liao L, Xu J, Bissig-Choisat B, Slagle BL, Bissig K-D. " A hepatitis B virus transgenic mouse model with a conditional, recombinant, episomal genome. " JHEP Reports. 2021 ; 3 (2) : 100252.
Dearth RK, Kuiatse I, Wang YF, Liao L, Hilsenbeck SG, Brown PH, Xu J, Lee AV. " " BMC Cancer. 2011 ; 11 : 377.
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Liao L, Kuang SQ, Yuan YH, Xu JM. " " Shi Yan Sheng Wu Xue Bao. 2002 Sep ; 35 (3) : 163-8.
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Hartmaier RJ, Richter AS, Gillihan RM, Sallit JZ, McGuire SE, Wang J, Lee AV, Osborne CK, O'Malley BW, Brown PH, Xu J, Skaar TC, Philips S, Rae JM, Azzouz F, Li L, Hayden J, Henry NL, Nguyen AT, Stearns V, Hayes DF, Flockhart DA, Oesterreich S. " " Mol. Endocrinol.. 2012 Feb ; 26 (2) : 220-7.
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Matsuzaki K, Xu J, Wang F, McKeehan WL, Krummen L, Kan M. " " J. Biol. Chem.. 1993 Jun 15; 268 (17) : 12719-23.
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Shivaraju M, Chitta UK, Grange RMH, Jain IH, Capen D, Liao L, Xu J, Ichinose F, Zapol WM, Mootha VK, and Rajagopal J. " Airway stem cells sense hypoxia and differentiate into protective solitary neuroendocrine cells. " Science. 2021 ; 371 (6524) : 52-7.
Gatza CE, Dumble M, Kittrell F, Edwards DG, Dearth RK, Lee AV, Xu J, Medina D, Donehower LA. " " Dev. Biol.. 2008 Jan 1; 313 (1) : 130-41.
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Wang F, Kan M, Yan G, Xu J, McKeehan WL. " " J. Biol. Chem.. 1995 Apr 28; 270 (17) : 10231-5.
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Kan M, Wang F, Xu J, Crabb JW, Hou J, McKeehan WL. " " Science. 1993 Mar 26; 259 (5103) : 1918-21.
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He Y, Hooker E, Yu EJ, Cunha G, Liao L, Xu J, Earl A, Wu H, Gonzalgo M, Sun Z. " Androgen signaling is essential for development of prostate cancer initiated from prostate basal cells. " Oncogene. 2019 ; 38 (13) : 2337-50.
Wang Z, Zhang F, He J, Wu P, Tay LWR, Cai M, Nian W, Wang Y, Qin L, Chang JT, McIntire LB, Di Paolo GD, Xu J, Peng J, Du G. " Binding of PLD2-generated phosphatidic acid to KIF5B promotes MT1-MMP surface trafficking and lung metastasis of mouse breast cancer cells. " Dev Cell. 2017 ; 43 (2) : 186-97.
Xu Y, Lee D-K, Feng Z, Xu Ya, Bu W, Li Y, Liao L, Xu J. " Breast tumor cell-specific knockout of Twist1 inhibits cancer cell plasticity, dissemination and lung metastasis in mice. " Proc Natl Acad Sci USA. 2017 ; 114 (43) : 11494-99.
Ding Y, Liu Y, Lee, D-K, Tong Z, Yu X, Li Y, Xu Y, Lanz R, O’Malley BW, Xu J. " Cell lineage tracing links ER loss in Erbb2-induced breast cancer cells to the arising of a highly proliferative and metastatic breast cancer subtype. " Proc Natl Acad Sci USA. 2021 ; 118 (21) : e2100673118.
Viswakarma N, Jia Y, Bai L, Vluggens A, Borensztajn J, Xu J, Reddy JK. " " PPAR Res. 2010 ; 2010
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Lanza DG, Gaspero A, Lorenzo I, Liao L, Zheng P, Wang Y, Deng Y, Cheng C, Zhang C, Seavitt JR, DeMayo FJ, Xu J, Dickinson ME, Beaudet AL, Heaney JD. " Comparative analysis of single-stranded DNA donors to generate conditional null mouse alleles. " BMC Biology. 2018 ; 16 (1) : 69.
Shi E, Kan M, Xu J, Wang F, Hou J, McKeehan WL. " " Mol. Cell. Biol.. 1993 Jul ; 13 (7) : 3907-18.
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Ma X, Xu L, Wang S, Cui B, Li X, Xu J, Ning G. " " J. Hepatol.. 2011 Aug ; 55 (2) : 445-52.
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Ying H, Furuya F, Willingham MC, Xu J, O'Malley BW, Cheng SY. " " Mol. Cell. Biol.. 2005 Sep ; 25 (17) : 7687-95.
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Han SJ, Jeong J, Demayo FJ, Xu J, Tsai SY, Tsai MJ, O'Malley BW. " " Mol. Cell. Biol.. 2005 Sep ; 25 (18) : 8150-65.
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Mödder UI, Sanyal A, Kearns AE, Sibonga JD, Nishihara E, Xu J, O'Malley BW, Ritman EL, Riggs BL, Spelsberg TC, Khosla S. " " Endocrinology. 2004 Feb ; 145 (2) : 913-21.
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Xu J, Nakahara M, Crabb JW, Shi E, Matuo Y, Fraser M, Kan M, Hou J, McKeehan WL. " " J. Biol. Chem.. 1992 Sep 5; 267 (25) : 17792-803.
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Yang Z, Wolf IM, Chen H, Periyasamy S, Chen Z, Yong W, Shi S, Zhao W, Xu J, Srivastava A, Sánchez ER, Shou W. " " Mol. Endocrinol.. 2006 Nov ; 20 (11) : 2682-94.
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Zhang P, Chen Y, Gong M, Zhuang Z, Wang Y, Mu L, Wang T, Pan J, Liu Y, Xu J, Liang R, Yuan Y. " Gab2 Regulates the Stemness of HER2-overexpressed Breast Cancer Cell. " Cell Physiol Biochem. 2018 ; 50 : 52-65.
Xiao Y, Xu J, Wang S, Mao C, Jin M, Ning G, Xu J, Zhang Y. " " Glia. 2010 Jun ; 58 (8) : 932-42.
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Song EC, Min S, Oyelakin A, Smalley K, Bard JE, Liao L, Xu J, Romano RA. " Genetic and scRNA-seq Analysis Reveals Distinct Cell Populations that Contribute to Salivary Gland Development and Maintenance. " Sci Rep. 2018 ; 8 (1) : 14043.
Park SE, Xu J, Frolova A, Liao L, O'Malley BW, Katzenellenbogen BS. " " Mol. Cell. Biol.. 2005 Mar ; 25 (5) : 1989-99.
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Xu J, Matsuzaki K, McKeehan K, Wang F, Kan M, McKeehan WL. " " Proc. Natl. Acad. Sci. U.S.A.. 1994 Aug 16; 91 (17) : 7957-61.
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Zerrad-Saadi A, Lambert-Blot M, Mitchell C, Bretes H, Collin de l'Hortet A, Baud V, Chereau F, Sotiropoulos A, Kopchick JJ, Liao L, Xu J, Gilgenkrantz H, Guidotti JE. " " Endocrinology. 2011 Jul ; 152 (7) : 2731-41.
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McCartan D, Bolger JC, Fagan A, Byrne C, Hao Y, Qin L, McIlroy M, Xu J, Hill AD, Gaora PÓ, Young LS. " " Cancer Res.. 2012 Jan 1; 72 (1) : 220-9.
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Sang M, Hulsurkar M, Zhang X, Song H, Zheng D, Zhang Y, Li M, Xu J, Zhang S, Ittmann M, Li W. " GRK3 is a direct target of CREB activation and regulates neuroendocrine differentiation of prostate cancer cells. " Oncotarget. 2016 ; 7 (29) : 45171-85.
Peng K, Su G, Ji J, Yang X, Miao M, Mo P, Li M, Xu J, Li W, Yu C. " Histone demethylase JMJD1A promotes colorectal cancer growth and metastasis by enhancing Wnt/β-catenin signaling. " J Biol Chem. 2018 ; 293 (27) : 10606-19.
Zhang QJ, Tran TAT, Wang M, Ranek MJ, Kokkonen-Simon KM, Gao J, Luo X, Tan W, Krychenko V, Liao L, Xu J, Hill JA, Olson EN, Kass DA, Martinez ED, and Liu Z-P. " Histone lysine dimethyl-demethylase KDM3A controls pathological cardiac hypertrophy and fibrosis. " Nat Commun. 2018 ; 9 (1) : 5230.
Li Q, Xu J. " " Int. J. Biol. Sci.. 2011 ; 7 (5) : 505-16.
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Xu J, Liao L, Qin J, Xu J, Liu D, Songyang Z. " " J. Biol. Chem.. 2009 May 22; 284 (21) : 14377-85.
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IJpenberg A, Tan NS, Gelman L, Kersten S, Seydoux J, Xu J, Metzger D, Canaple L, Chambon P, Wahli W, Desvergne B. " " EMBO J.. 2004 May 19; 23 (10) : 2083-91.
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Xu J, McKeehan K, Matsuzaki K, McKeehan WL. " " J. Biol. Chem.. 1995 Mar 17; 270 (11) : 6308-13.
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Prudovsky I, Savion N, Zhan X, Friesel R, Xu J, Hou J, McKeehan WL, Maciag T. " " J. Biol. Chem.. 1994 Dec 16; 269 (50) : 31720-4.
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Goo YH, Na SY, Zhang H, Xu J, Hong S, Cheong J, Lee SK, Lee JW. " " J. Biol. Chem.. 2004 Feb 20; 279 (8) : 7131-5.
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McKeehan K, McKeehan WI, Xu J, Liao L. " " In Vitro Cell. Dev. Biol. Anim.. 1996 Mar ; 32 (3) : 131-4.
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Zhang B, Ci X, Tao R, Ni J, Xuan X, King J, Xia S, Li Y, Frierson H, Lee D-K, Xu J, Osunkoya A, Dong JT. " Klf5 acetylation regulates luminal differentiation of basal progenitors in prostate development and regeneration. " Nat Commun. 2020 ; 11 (1) : 997.
Wang WL, Li Q, Xu J, Cvekl A. " " Mol. Biol. Cell. 2010 Jul 15; 21 (14) : 2453-68.
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Wang F, Kan M, Xu J, Yan G, McKeehan WL. " " J. Biol. Chem.. 1995 Apr 28; 270 (17) : 10222-30.
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Xi Y, Kim T, Brumwell AN, Driver I, Wei Y, Tan V, Jackson J, Xu J, Lee D-K, Gotts J, Matthay M, Shannon JM, Chapman HA, Vaughan AE. " Local lung hypoxia determines epithelial fate decisions during alveolar regeneration. " Nat Cell Biol. 2017 ; 19 (9) : 904-14.
Ma X, Xu L, Wang S, Chen H, Xu J, Li X, Ning G. " " Lab. Invest.. 2009 Aug ; 89 (8) : 903-14.
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Weiss RE, Xu J, Ning G, Pohlenz J, O'Malley BW, Refetoff S. " " EMBO J.. 1999 Apr 1; 18 (7) : 1900-4.
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Kamiya Y, Zhang XY, Ying H, Kato Y, Willingham MC, Xu J, O'Malley BW, Cheng SY. " " Endocrinology. 2003 Sep ; 144 (9) : 4144-53.
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Xu J, O'Malley BW. " " Rev Endocr Metab Disord. 2002 Sep ; 3 (3) : 185-92.
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Liao L, Kuang SQ, Yuan Y, Gonzalez SM, O'Malley BW, Xu J. " " J. Steroid Biochem. Mol. Biol.. 2002 Dec ; 83 (41279) : 41347.
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Lee D-K, Liu Y, Liao L, Li W, Danielpour D, and Xu J. " Neuroendocrine prostate carcinoma cells originate from the p63-expressing basal cells but not the pre-existing adenocarcinoma cells in mice. " Cell Res. 2019 ; 29 (5) : 420-2.
Wu HY, Hamamori Y, Xu J, Chang SC, Saluna T, Chang MF, O'Malley BW, Kedes L. " " J. Biol. Chem.. 2005 Feb 4; 280 (5) : 3129-37.
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Feng S, Xu J, Wang F, Kan M, McKeehan WL. " " Biochim. Biophys. Acta. 1996 Jan 10; 1310 (1) : 67-73.
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McKenna NJ, Xu J, Nawaz Z, Tsai SY, Tsai MJ, O'Malley BW. " " J. Steroid Biochem. Mol. Biol.. ; 69 (41280) : 41345.
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Nishihara E, O'Malley BW, Xu J. " " Mol. Neurobiol.. 2004 Dec ; 30 (3) : 307-25.
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Wu H, Bi J, Peng Y, Huo L, Yu X, Yang Z, Zhou Y, Qin L, Xu Y, Liao L, Xie Y, Conneely OM, Jonkers J, Xu J. " Nuclear Receptor NR4A1 Is a Tumor Suppressor Down-regulated in Triple-Negative Breast Cancer. " Oncotarget. 2017 ; 8 : 54364-77.
Wang Y, Xu J, Pierson T, O'Malley BW, Tsai SY. " " Gene Ther.. 1997 May ; 4 (5) : 432-41.
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Yuan B, Liu J, Cao J, Yu Y, Zhang H, Wang F, Zhu Y, Xiao M, Liu S, Ye Y, Ma L, Xu D, Xu N, Li Y, Zhao B, Xu P, Jin J, Xu J, Chen X, Shen L, Lin X, Feng XH. " PTPN3 Acts as a Tumor Suppressor and Boosts TGF-β Signaling Independent of its Phosphatase Activity. " EMBO J. 2019 ; 38 (14) : e99945.
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