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Jeanine L Van Nostrand

Van Nostrand

Jeanine L Van Nostrand, Ph.D.

Assistant Professor

Email

jeanine.vannostrand@bcm.edu

Positions

Assistant Professor
Molecular and Cellular Biology
ÌÇÐÄÊÓƵ of Medicine
Houston, TX
CPRIT Scholar in Cancer Research
Cancer Prevention and Research Institute of Texas (CPRIT)
Member
Dan L Duncan Comprehensive Cancer Center (BCM)
Houston,, TX
Member
Center for Metabolism and Experimental Therapeutics (BCM)
Faculty Member
Development, Disease Models & Therapeutics Graduate Program
Faculty Member
Cancer & Cell Biology Graduate Program

Education

Postdoctoral Fellowship at Reuben Shaw Lab, The Salk Institute for Biological Studies
La Jolla, California
PhD from Laura Attardi Lab, Stanford University
06/2014 - Stanford, California
Cancer Biology
BS from University of Nebraska- Lincoln
05/2003 - Lincoln, Nebraska
Biochemistry

Professional Interests

  • Mouse models of cancer and metabolic disease
  • AMPK and mTOR pathways
  • Hepatocellular carcinoma and Non-small cell lung Cancer

Professional Statement

Cells require energy to grow. Cancer occurs when cells find ways to circumvent limitations on energy, either through inhibiting pathways that prevent growth, activating pathways that promote growth, or finding new sources of energy. Two pathways critical for sensing the amount of energy in the cell and deciding whether cells should grow are the AMPK and mTOR pathways. Alterations in both of these pathways are implicated in cancer and metabolic disease. My lab is focused on 1) understanding the causative role of AMPK in hepatocellular carcinoma and 2) dissecting the role of AMPK-dependent regulation of mTOR in metabolic disease and cancer.

Selected Publications

  • Van Nostrand, J.L., Hellberg, K., Luo, E.C., Van Nostrand, E.L., Dayn, A., Yu, J., Shokhirev, M.N., Dayn, Y., Yeo, G.W., Shaw, R.J.. " " Genes Dev. 2020 ; 34 : 1330-1344.
    Pubmed PMID: .
  • Van Nostrand, J.L., Attardi, L.D. " " Cell Cycle. 2014 ; 13 (24) : 3798-807.
    Pubmed PMID: .
  • Van Nostrand JL, Brady CA, Jung H, Fuentes DR, Kozak MM, Johnson TM, Lin CY, Lin CJ, Swiderski DL, Vogel H, Bernstein JA, Attié-Bitach T, Chang CP, Wysocka J, Martin DM, Attardi LD. " " Nature. 2014 ; 514 : 228-32.
    Pubmed PMID: .
  • Jacob, S.B.R., Van Nostrand, J.L., Bowen, M.E., Baker, J.C., Attardi, L.D.. " " Cell Death Differ. 2019 ; 27 (1) : 297-309.
    Pubmed PMID: .

Funding

CPRIT Scholar in Cancer Research
Cancer Prevention and Research Institute of Texas (CPRIT) (12/2020-11/2025
Damon Runyon Postdoctoral Fellow
Damon Runyon Cancer Research Foundation (1/2015-1/2019)

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