Jamunarani Veeraraghavan, Ph.D.,
Assistant Professor
Positions
- Assistant Professor
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Breast Center - Schiff-Osborne lab
ÌÇÐÄÊÓƵ of Medicine
Houston, TX, US
- Member
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Dan L Duncan Comprehensive Cancer Center
ÌÇÐÄÊÓƵ of Medicine
Houston, Texas, United States
Education
- PhD from The University of Oklahoma Health Sciences Center
- 05/2012 - Oklahoma City, Oklahoma, United States
- Pathology
Professional Interests
- Cancer cell biology, Gene fusion, Preclinical tumor models, HER2-positive breast cancer, Precision Medicine, Treatment resistance, ERBB2 mutations, HER2-targeted therapy
Professional Statement
Through a correlative biomarker study using tumor specimens from chemotherapy-sparing neoadjuvant clinical trial, we recently demonstrated that there is a clinical subtype in breast cancer with high HER2 amplification and intact PI3K pathway that is especially sensitive to HER2-targeted therapy, without chemotherapy.
My current primary research interests are: i) delineate the mechanisms of resistance to potent HER2-targeted therapies, ii) unravel the genomic complexity of HER2-positive metastatic breast cancer, with a particular focus on brain metastasis, and iii) develop treatment strategies to effectively circumvent resistance and metastasis in HER2-positive breast cancer.
My current primary research interests are: i) delineate the mechanisms of resistance to potent HER2-targeted therapies, ii) unravel the genomic complexity of HER2-positive metastatic breast cancer, with a particular focus on brain metastasis, and iii) develop treatment strategies to effectively circumvent resistance and metastasis in HER2-positive breast cancer.
Websites
Selected Publications
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Veeraraghavan J, Tan Y, Cao X, Kim JA, Wang X, Chamness G.C, Maiti S.N, Laurence J.N. Cooper, Edwards D.P, Contreras A, Hilsenbeck S.G, Chang E.C, Schiff R and Wang X-S. " " Nat Commun. 2014 Aug 7; 5 (1) : 1-12.
Pubmed PMID: . -
Xu X, De Angelis C, Burke KA, Nardone A, Hu H, Qin L, Veeraraghavan J, et al.,. " " Clin Cancer Res. 2017 Jan 9; 23 (17) : 5123-5134.
Pubmed PMID: . -
Veeraraghavan J, De Angelis C, Reis-Filho JS, Prat A, Rimawi MF, Pascual T, Osborne CK, Schiff R.. " " Breast. 2017 Aug ; 34 (Suppl) : S19-S26.
Pubmed PMID: . -
Goutsouliak K*, Veeraraghavan J*, Sethunath V, De Angelis C, Osborne CK, Rimawi MF, Schiff R. *contributed equally. " " Nat Rev Clin Oncol. 2020 Apr ; 17 (4) : 233-250.
Pubmed PMID: .
Skills
- Cancer cell and molecular biology
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