Indira Mysorekar

Indira Mysorekar, Ph.D.

indira.mysorekar@bcm.edu

Professor of Medicine; Chief of Basic and Translational Research: Medicine
Infectious Diseases
��Ƶ of Medicine
Houston, TX, USA

E.I. Wagner Endowed, M.D., Chair Internal Medicine II: Department of Medicine
Infectious Diseases
��Ƶ of Medicine
Houston, Texas, United States

PhD from Washington University School of Medicine: 05/2002 - St. Louis, Missouri, United States

J. Christian Herr Award from the American Society for Reproductive Immunology: (01/2021)

Outstanding Graduate Student Mentor award (2019 Mentor of the Year at Washington University): (01/2019)

Verma S, Joshi CS, Silverstein RB, He M, Carter EB, Mysorekar IU. " " Med (N Y). 2021 May 14; 2303-2313.
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Cao B, Parnell LA, Diamond MS, Mysorekar IU. " " J Exp Med. 2017 Aug 7; 575-590.
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Miner JJ, Cao B, Govero J, Smith AM, Fernandez E, Cabrera OH, Garber C, Noll M, Klein RS, Noguchi KK, Mysorekar IU, Diamond MS.. " " 2016 May 19; 1081-1091.
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Ligon MM, Wang C, DeJong EN, Schulz C, Bowdish DME, Mysorekar IU.. " " 2020 Nov 13; 908-918.
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Meister MR, Wang C, Lowder JL, Mysorekar IU.. " " 2021 Jan 1; e39-e44.
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Wang C, Bauckman KA, Ross ASB, Symington JW, Ligon MM, Scholtes G, Kumar A, Chang HW, Twentyman J, Fashemi BE, Xavier RJ, Mysorekar IU. " " 2019 Mar 15; 527-542.
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Interleukin-6 and Aging: Impact on Immune Defense and Tissue Repair in Urinary Bladder #R01AG052494: (09/30/2016 - 05/31/2021); Grant funding from NIH NIA; Recurrent urinary tract infections afflict millions of post-menopausal women in the US each year, imposing a tremendous personal and financial burden on society. Our goal here is to understand how the sex hormone estrogen regulates the course of UTIs and bladder recovery after the infection. This work will lead to development of therapeutic interventions for this recalcitrant disease in aging menopausal populations.

Mechanisms of Zika Virus Maternal-Fetal Transmission #R01HD091218: (04/01/2017 - 03/31/2022); Grant funding from NIH NICHD; The goal of this proposal is to identify how ZIKV is able to cross the placental barrier to cause adverse outcomes in the baby. This work has significant clinical implications for understanding ZIKV-pathology and for developing strategies for mitigating ZIKV trafficking through the placenta and thus reducing adverse outcomes.

Molecular and neuro-inflammatory biology of aging bladder in normal and disease states #P20DK119840: (12/01/2018 - 03/01/2021); Grant funding from NIH NIDDK; This goal of this project is to facilitate collaborations between IIT Mandi (Giri lab) and Washington University (Mysorekar lab) to understand the biophysics of Zika virus membrane fusion and host placental pathogenesis

Mechanism of age-associated inflammation and lymphoid neogenesis in the urinary bladder #R56 AG064634: (07/01/2019 - 06/30/2024); Grant funding from NIH NIA; The goal of this project is to define the cellular mechanisms driving chronic inflammation and response to recurrent urinary tract infections in the elderly, to develop and identify biomarkers of age-related immune function changes that can be used to guide future clinical trials and treatment strategies to improve responses to infections in the elderly.

Molecular and neuro-inflammatory biology of aging bladder in normal and disease states: Administrative Core #P20DK119840-01(5404): (09/01/2018 - 06/01/2021); Grant funding from NIH NIDDK

Safety, Testing/Transmission, and Outcomes in Pregnancy with COVID-19 (STOP-COVID19) #3R01HD091218-04S1: (11/01/2020 - 10/31/2022); NIH NICHD RADX-UP; The goal of the study is to examine the factors that impede testing for SARS-CoV-2, help determine optimal testing strategies, inform prenatal care plans, and contribute to our ability to counsel women and create prenatal care plans if they are pregnant or considering pregnancy.

Role of Gut Microbiota in Endometriosis #R01HD102680: (04/01/2021 - 03/31/2026); Grant funding from NIH NICHD; The goal of the project is to test that whereas some gut bacteria promote endometriosis by inducing inflammation, others protect against endometriosis by fermenting fiber to produce short chain fatty acids.

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