Hyun-Sung Lee, M.D., Ph.D.
Associate Professor of Surgery
Positions
- Associate Professor of Surgery
-
Michael E. DeBakey Department of Surgery
David J. Sugarbaker Division of Thoracic Surgery
糖心视频 of Medicine
HOUSTON, Texas, United States
- Director
-
Systems Onco-Immunology Lab
- Member
-
Dan L Duncan Comprehensive Cancer Center
- Co-Leader
-
DLDCCC Cancer Immunology Special Interest Group
Addresses
- Laboratory (Lab)
-
Alkek Building for Biomedical Research
Houston, TX, 77030
United States
Education
- Research Fellowship at Systems Biology, UT MD Anderson Cancer Center
- HOUSTON, Texas, United States
- Clinical Fellowship at Thoracic Surgery, Center for Lung Cancer, National Cancer Center
- Goyang, Republic of Korea
- PhD from Yonsei University College of Medicine
- Seoul, Republic of Korea
- Residency at Department of Thoracic and Cardiovascular Surgery, Severance Hospital, Yonsei University College of Medicine
- Seoul, Republic of Korea
- MD from Yonsei University College of Medicine
- Seoul, Republic of Korea
Honors & Awards
- PEAR (Professional Educator Appreciation and Recognition) Award
- 糖心视频 of Medicine (08/2022)
- O.H. Frazier, M.D. Innovation Awards
- 糖心视频 of Medicine (10/2022)
- Waun Ki Hong Memorial Award
- Severance Alumni Association of USA (11/2022)
- The Power of Professionalism (POP) Award
- 糖心视频 of Medicine (03/2023)
- Michael E. DeBakey Faculty Research Award
- BAYLOR COLLEGE OF MEDICINE (07/2021 - 06/2022)
Professional Interests
- Systems Onco-Immunology
- Malignant pleural mesothelioma
- Lung cancer
- Single-Cell Multi-Omics
- Immunoproteogenomics
Professional Statement
Dr. Lee is a tenured Associate Professor of the Michael E. DeBakey Department of Surgery at 糖心视频 of Medicine (BCM). He has more than ten years of experience treating lung cancer and esophageal cancer as an attending thoracic surgeon, three years of research in the Department of Systems Biology at UT MD Anderson Cancer Center, and eight years of immunology research in the Michael E. DeBakey Department of Surgery at BCM. Dr. Lee is Director of the Systems Onco-Immunology Lab (SOIL) at BCM, in which the 10XGenomics Chromium X and Chromium Controller are equipped to generate single-cell libraries for single-cell multi-omics platforms, including single-cell RNA sequencing with TCR analysis. He is particularly enthusiastic about 鈥渟ystems onco-immunology,鈥 with specific experience in comprehensively integrating high-dimensional single-cell time-of-flight mass cytometry (CyTOF), imaging mass cytometry (IMC), mass spectrometry鈥揵ased immunopeptidomics, and single-cell multi-omics data. He has applied innovative immunoproteomic and immunogenomic approaches to this framework to understand the mechanisms underlying clinical outcomes and primary or acquired resistance to immunotherapy in these diseases. He continues to characterize and unravel the cellular immune network by analyzing human and mouse single-cell data, correlating immune composition with immunogenomic determinants to predict clinical prognosis and response to checkpoint immunotherapy.
Dr. Lee's strongest expertise lies in grasping the clinical implications of translational research and bridging our advancing science to meet the critical needs within immuno-oncology. His overarching goals are to identify potential therapeutic targets to overcome resistance to checkpoint immunotherapy and to investigate the cellular mechanism of tumor immunity and autoimmunity after immunotherapy by applying 鈥渃omprehensive and integrated systems immunology鈥 approaches.
Dr. Lee's strongest expertise lies in grasping the clinical implications of translational research and bridging our advancing science to meet the critical needs within immuno-oncology. His overarching goals are to identify potential therapeutic targets to overcome resistance to checkpoint immunotherapy and to investigate the cellular mechanism of tumor immunity and autoimmunity after immunotherapy by applying 鈥渃omprehensive and integrated systems immunology鈥 approaches.
Selected Publications
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Hyun-Sung Lee, Hee-Jin Jang, Jong Min Choi, Jun Zhang, Veronica Lenge de Rosen, Thomas M. Wheeler, Ju-Seog Lee, Thuydung Tu, Peter T. Jindra, Ronald H. Kerman, Sung Yun Jung, Farrah Kheradmand, David J. Sugarbaker, and Bryan M. Burt. " " Comprehensive immunoproteogenomic analyses of malignant pleural mesothelioma JCI Insight. 2018 Apr 5;
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Jang HJ, Truong CY, Lo EM, Holmes HM, Ramos D, Ramineni M, Lee JS, Wang DY, Pietropaolo M, Ripley RT, Burt BM, Lee HS. " " Ann Thorac Surg. 2021 Sep ;
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Lee HS, Jang HJ, Ramineni M, Wang DY, Ramos D, Choi JM, Splawn T, Espinoza M, Almarez M, Hosey L, Jo E, Hilsenbeck S, Amos CI, Ripley RT, Burt BM. " " Clin Cancer Res. 2023 Feb ; 29 (3) : 248-559.
Pubmed PMID: . -
Jang HJ, Lee HS, Yu W, Ramineni M, Truong CY, Ramos D, Splawn T, Choi JM, Jung SY, Lee JS, Wang DY, Sederstrom JM, Pietropaolo M, Kheradmand F, Amos CI, Wheeler TM, Ripley RT, Burt BM. " " Cancer Res. 2022 Jul ; 82 (14) : 2593-2609.
Pubmed PMID: .
Memberships
- Dan L Duncan Comprehensive Cancer Center member
- Research Member (03/2023)
- American Association for Thoracic Surgery (AATS)
- Member
Funding
-
Individual Investigator Research Awards 2020
- (03/01/2020 - 02/29/2024)
- Grant funding from CPRIT
- the Cancer Prevention and Research Institute of Texas
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Investigator-Initiated Sponsored Research
- (06/01/2021 - 05/31/2024)
- Grant funding from Samyang Biopharm USA
- Therapeutic targeting of MIC-NKG2D signal to overcome resistance to checkpoint immunotherapy
-
Peer Reviewed Cancer Research Program Impact Award
- Grant funding from Department Of Defense
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