Positions
- Associate professor
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Pediatrics
Neurology
ÌÇÐÄÊÓƵ of Medicine
Houston, TX, US
- Principal Investigator
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Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital
- Cynthia and Anthony G. Petrello Endowed Scholar in Neurological Research
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Texas Children's Hospital
- Associate Professor
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Dan L Duncan Comprehensive Cancer Center
ÌÇÐÄÊÓƵ of Medicine
Houston, Texas, United States
Addresses
- Departments of Pediatrics and Neuroscience (Office)
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Neurological Research Institute
Houston, TX, 77030
United States
- Departments of Pediatrics and Neuroscience (Lab)
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Neurological Research Institute
Houston, TX, 77030
United States
Education
- BS from University of Dong-A
- 02/2004 - Busan, South Korea
- Biotechnology
- PhD from Dong-A College of Medicine
- 02/2009 - Busan, South Korea
- Physiology, Neuroscience
- Postdoctoral Fellowship at ÌÇÐÄÊÓƵ of Medicine
- 12/2015 - Houston, Texas, United States
- Glial development
Honors & Awards
- Career Transition Award
- National Multiple Sclerosis Society
- Research Mentor Award
- Dept Pediatrics, BCM/TCH
- Young Investigator Award
- Dept Pediatrics, BCM/TCH
Professional Interests
- Elucidating mechanisms of gliogenesis in neural development and how its dysfunction can lead to neurodegenerative diseases
Professional Statement
In my laboratory, we plan to take an interdisciplinary approach to the study of neural development and eventually neurodegenerative disease. Glia play diverse roles in the functioning CNS and, consequently, are associated with numerous neurological disorders and malignancies. In spite of their vital role in CNS physiology and pathology, the molecular mechanisms that control their development and diversity remain poorly defined; accordingly, how these processes contribute to CNS pathology also remains undefined. Therefore, our studies focus on the identification of novel molecular signaling and regulatory pathway in glial cell development by manipulation both chick and mouse model systems and biochemical techniques combined with an array of complex CNS injury models. These studies will provide the foundation upon which we will translate developmentally relevant findings to demyelinating diseases and neurodegenerative disorders in an effort to develop therapeutic interventions.
Websites
Selected Publications
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Cristobal CD, Lee HK.. " " Glia. 2022 Jul ;
Pubmed PMID: . -
Cristobal CD*, Wang C*, Zuo Z, Smith J, Bellen H, Lee HK. " " J. Neurosci.. 2022 Mar ;
Pubmed PMID: . -
Jo J, Woo J, Cristobal CD, Choi JM, Wang CY, Ye Q, Smith JA, Ung K, Liu G, Cortes D, Jung SY, Arenkiel BR, Lee HK.. " " EMBO Rep. 2021 Dec ;
Pubmed PMID: . -
Ding X, Jo J, Cristobal DC, Zuo Z, Wang CY, Wirianto M, Ye Q, Lindeke-Myers A, Choi JM, Mohila CA, Kawabe H, Jung SY, Bellen H, Yoo, SH, Lee HK. " " Genes Dev. 2020 Sep ; 1 (34(17-18)) : 1177-1189.
Pubmed PMID: .
Funding
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R01NS110859
- NIH/NINDS R01
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R01DE021798-06A1
- NIH/NIDCR R01
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RG 1907-34551
- National Multiple Sclerosis Society
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Research grant
- Helis Medical Research Foundations
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Research grant
- Mark A. Wallace Endowment Award
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