Huaizhu Wu

Huaizhu Wu, M.D.

Professor

(713) 798-4141

Email

hwu@bcm.edu

Positions

Professor: Medicine-Athero & Lipo
��Ƶ of Medicine
Houston, TX, US

Addresses

506D (Office): One Baylor Plaza, MS BCM285
Houston, TX, 77030
United States
Phone: (713) 798-4141
hwu@bcm.edu

Education

MD from Weifang Medical College: Weifang, China, People's Rep

MS from Peking Union Medical College: Beijing, China, People's Rep

Postdoctoral Fellowship at ��Ƶ of Medicine: Houston, Texas, United States

Professional Interests

Obesity, inflammation and insulin resistance
Lipids, monocytes/macrophages and atherosclerosis
Basic and translational research

Professional Statement

My research focuses on the role of inflammation in the development of atherosclerosis and diabetes associated with dyslipidemia and obesity. Using animal models of disease with ablation of interested molecules in specific tissues/cells, human specimens, cell and molecular biology technology, histology, and flow cytometry, we conduct basic and translational research on effects of hyperlipidemia and obesity on monocyte/macrophage phenotypes and their contributions to atherosclerosis and adipose tissue inflammation associated with diet-induced obesity and its role in obesity-linked diseases including insulin resistance, diabetes and atherosclerosis.

Websites

Selected Publications

Xu L, Perrard XYD, Perrard JL, Yang D, Xiao X, Teng B, Simon SI, Ballantyne CM, Wu H. " " Arterioscler Thromb Vasc Biol. 2015 ; 35 (8) : 1787-1797.
Pubmed PMID: .
Khan IM, Perrard XYD, Brunner G, Liu H, Sparks LM, Smith SR, Wang K, Shi ZZ, Lewis DE, Wu H, Ballantyne CM. " " Intern J Obesity. 2015 ; Jun 4. doi: 10..
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Wu H, Ballantyne CM. " " Cell Metab.. 2014 ; 20 : 708-709.
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Lim H, Kim YU, Sun H, Lee JH, Reynolds JM, Hanabuchi S, Wu H, Teng BB, Chung Y. " " Immunity. 2014 ; 40 (1) : 153-65.
Pubmed PMID: .
Jiang E, Perrard XD, Yang D, Khan IM, Perrard JL, Smith CW, Ballantyne CM, Wu H. " " Arterioscler Thromb Vasc Biol. 2014 ; 34 (1) : 34-43.
Pubmed PMID: .
Khan IM, Dai Perrard XY, Perrard JL, Mansoori A, Smith CW, Wu H, Ballantyne CM. " " Atherosclerosis. 2014 ; 233 (2) : 419-28.
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Wang J, Perrard XD, Perrard JL, Mukherjee A, Rosales C, Chen Y, Smith CW, Pownall HJ, Ballantyne CM, Wu H. " " Atherosclerosis.. 2012 ; 223 (2) : 342-9.
Pubmed PMID: .
Wang Q, Perrard XD, Perrard JL, Mansoori A, Raya JL, Hoogeveen R, Smith CW, Ballantyne CM, Wu H. " " Atherosclerosis. 2011 ; 219 (1) : 100-8.
Pubmed PMID: .
Wu H, Perrard XD, Wang Q, Perrard JL, Polsani VR, Jones PH, Smith CW, Ballantyne CM. " " Arterioscler Thromb Vasc Biol.. 2010 ; 30 (2) : 186-92.
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Wu H, Gower RM, Wang H, Perrard XY, Ma R, Bullard DC, Burns AR, Paul A, Smith CW, Simon SI, Ballantyne CM. " " Circulation. 2009 ; 119 (20) : 2708-17.
Pubmed PMID: .
Wu H, Ghosh S, Perrard XD, Feng L, Garcia GE, Perrard JL, Sweeney JF, Peterson LE, Chan L, Smith CW, Ballantyne CM. " " Circulation. 2007 ; 115 (8) : 1029-38.
Pubmed PMID: .
Wu H, Ballantyne CM. " " Nat Rev Cardiol. 2017 Jul ; 14 (7) : 385-386.
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Wu H, Ballantyne CM. " " J Clin Invest. 2017 Jan 3; 127 (1) : 43-54.
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Khan IM, Pokharel Y, Dadu RT, Lewis DE, Hoogeveen RC, Wu H, Ballantyne CM. " " J Clin Endocrinol Metab. 2016 Nov ; 101 (11) : 4195-4204.
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Zhou H, Ran Y, Da Q, Shaw TS, Shang D, Reddy AK, López JA, Ballantyne CM, Ware J, Wu H, Peng Y. " " J Immunol. 2016 Jul 1; 197 (1) : 288-295.
Pubmed PMID: .
Lin L, Lee JH, Buras ED, Yu K, Wang R, Smith CW, Wu H, Sheikh-Hamad D, Sun Y. " " Aging. 2016 Jan ; 8 (1) : 178-191.
Pubmed PMID: .
Foster GA, Xu L, Chidambaram AA, Soderberg SR, Armstrong EJ, Wu H, Simon SI. " " J Immunol.. 2015 Dec 1; 195 (11) : 5380-5392.
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Wu H, Ballantyne CM.. " " Circ Res. 2020 May 22; 126 (11) : 1549-1564..
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Antony A, Lian Z, Perrard XD, Perrard J, Liu H, Cox AR, Saha P, Hennighausen L, Hartig SM, Ballantyne CM, Wu H.. " " Diabetes. 2021 ; 70 : 720-732.
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Wu H, Xu L, Ballantyne CM.. " " J Clin Endocrinol Metab.. 2020 ; 105 : 1030-45.
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Lian Z, Perrard XD, Peng X, Raya JL, Hernandez AA, Johnson CG, Lagor WR, Pownall HJ, Hoogeveen RC, Simon SI, Sacks FM, Ballantyne CM, Wu H.. " " Arterioscler Thromb Vasc Biol.. 2020 ; 40 : 72-85.
Pubmed PMID: .
Wang Q, Wu H.. " " Front Immunol.. 2018 ; 9 : 2509.
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Kalathookunnel Antony A, Lian Z, Wu H.. " " Front Immunol.. 2018 ; 9 : 2945.
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Dai Perrard XY, Lian Z, Bobotas G, Dicklin MR, Maki KC, Wu H.. " " J Clin Lipidol.. 2017 ; 11 : 1361-1371.
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Wu J, Wu H, An J, Ballantyne CM, Cyster JG.. " " Proc Natl Acad Sci U S A.. 2018 ; 115 : 6786-6791.
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Lian Z, Saeed A, Peng X, Perrard XD, Jia X, Hussain A, Ballantyne CM, Wu H.. " " J Clin Lipidol.. 2020 ; 14 : 850-858.
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Cox AR, Masschelin PM, Saha PK, Felix JB, Sharp R, Lian Z, Xia Y, Chernis N, Bader DA, Kim KH, Li X, Yoshino J, Li X, Li G, Sun Z, Wu H, Coarfa C, Moore DD, Klein S, Sun K, Hartig SM. " " Cell Metab .. 2022 Dec 6; 34 (12) : 1932-1946.
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Peng X, Lian Z, Perrard XD, Xiao Y, Ni J, O'Brien V, Dong H, Pownall HJ, Ballantyne CM, Wu H.. " " Cells. 2022 May 30; 11 (11) : 1795.
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Peng X, Wu H.. " " Curr Atheroscler Rep.. 2022 May ; 24 (5) : 297-306..
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Mao H, Li L, Fan Q, Angelini A, Saha PK, Coarfa C, Rajapakshe K, Perera D, Cheng J, Wu H, Ballantyne CM, Sun Z, Xie L, Pi X.. " " Nat Commun.. 2021 Sep 6; 12 (1) : 5296.
Pubmed PMID: .

Funding

Regulation of type I inflammation in diet-induced obesity: Grant funding from NIH

Inflammation and insulin resistance in aging: Grant funding from NIH

Inflammatory link between hypertriglyceridemia and atherosclerosis: Grant funding from American Heart Association

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