Positions
- Associate Professor
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Pathology and Immunology
ÌÇÐÄÊÓƵ of Medicine
- Associate Professor
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Molecular & Cellular Biology
ÌÇÐÄÊÓƵ of Medicine
- Member
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Dan L Duncan Comprehensive Cancer Center
ÌÇÐÄÊÓƵ of Medicine
- Faculty Member
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Cancer & Cell Biology Graduate Program
ÌÇÐÄÊÓƵ of Medicine
- Faculty Member
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Development, Disease Models & Therapeutics Graduate Program
ÌÇÐÄÊÓƵ of Medicine
Addresses
- One Baylor Plaza (Office)
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Office: BCM-T221
Houston, TX, 77030-3411
United States
- One Baylor Plaza (Lab)
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Lab: BCM-T207
Houston, TX, 77030-3411
United States
Education
- PhD from Institute of Biophysics, Chinese Academy of Sciences
- Beijing, China
- Postdoctoral Training at ÌÇÐÄÊÓƵ of Medicine
- Houston, Texas, United States
Honors & Awards
- Idea Development Award
- DOD, Prostate Cancer Research Program, 2023
- Research Project Grant (R01)
- NCI/NIH, 2023
- Individual Investigator Research Award
- Cancer Prevention & Research Institute of Texas, 2020
- Breakthrough Award Funding Level 2
- DOD, Breast Cancer Research Program, 2017
- Collaborative Research Project with AHMMRF
- Adrienne Helis Malvin Medical Research Foundation, 2015
- Idea Development Award
- DOD, Prostate Cancer Research Program, 2013
- Individual Investigator Research Award
- Cancer Prevention & Research Institute of Texas, 2013
- Idea Development Award
- DOD, Prostate Cancer Research Program, 2013
- New Investigator Award
- DOD, Prostate Cancer Research Program, 2009
- Concept Award
- DOD, Breast Cancer Research Program, 2009
- Exploration-Hypothesis Development Award
- DOD, Prostate Cancer Research Program, 2007
Professional Interests
- MAPK4 biology in human cancers
- Signaling Pathways Regulating Prostate Cancer
- Therapy-resistance of Human Cancers
- Mouse Models for Human Cancers
- Tumor Microenvironment
Professional Statement
Focusing on cancer research, educating researchers, making discoveries, and turning discoveries into effective therapies for cancer patients.
Selected Publications
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Wang W, Shen T, Dong B, Creighton CJ, Meng Y, Zhou W, Shi Q, Zhou H, Zhang Y, Moore DD, Yang F. " " J Clin Invest. 2019 ; 129 (3) : 1015-29.
Pubmed PMID: . -
Shen T, Wang W, Zhou W, Coleman I, Cai Q, Dong B, Ittmann M, Creighton CJ, Bian Y, Meng Y, Rowley DR, Nelson PS, Moore DD, Yang F. " " J Clin Invest. 2021 ; 131 (4) : e135465.
Pubmed PMID: . -
Cai Q, Zhou W, Wang W, Dong B, Han D, Shen T, Creighton CJ, Moore DD, Yang F. " " Sci Adv. 2021 ; 7 (46) : eabi6439.
Pubmed PMID: . -
Shen T, Dong B, Meng Y, Moore DD, Yang F. " " Proc Natl Acad Sci U S A. 2022 ; 119 (43) : e2205350119.
Pubmed PMID: .
Projects
- MAPK4 biology in human cancers
- MAPK4 is an atypical MAPK that was not well studied. MAPK4 biology in human diseases, including cancers, was largely unknown. We discovered that MAPK4 activates Akt/mTOR and several other key signal pathways to promote cancer initiation, progression, and therapy-resistance. We are now pioneering the research on MAPK4 biology in human cancers and are carrying out in-depth studies to reveal the molecular mechanisms underlying MAPK4 regulation of human cancers.
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