Enrico Rey Barrozo

Enrico Rey Barrozo, Ph.D.

Assistant Professor

Email

enrico.barrozo@bcm.edu

Positions

Assistant Professor: Obstetrics & Gynecology
��Ƶ of Medicine
Houston, Texas, US

Faculty Member: Development, Disease Models & Therapeutics Graduate Program
��Ƶ of Medicine

Addresses

Barrozo Lab (Lab): One Baylor Plaza
210D
Houston, TX, 77030
United States

Barrozo Lab (Office): One Baylor Plaza
203D
Houston, TX, 77030
United States
Phone: (713) 798-7454

Professional Statement

At ��Ƶ of Medicine and Texas Children’s Hospital, I strive to understand the rules governing host-microbe interactions and early immune development. I have secured funding, including an NSF postdoctoral fellowship, an NIH Loan Repayment Award in Pediatrics, an R03 Maternal and Infant Environmental Health Riskscape (MIEHR) Pilot Award, and a $100,000 Career Development Award from the American Society for Gene & Cell Therapy (ASGCT). With this funding, we have pioneered spatial transcriptomics in human and mouse placenta tissue, identifying immune microenvironments in congenital ZIKV mouse models and placentae from human COVID-19 gravidae. We apply this approach to understand how environmental exposures, such as microplastic accumulation in the placenta, correlate with health disparities and developmental immunotoxicology. Additionally, we have conducted groundbreaking single-cell RNA-sequencing (scRNA-seq) studies on amniotic fluid and fetal cerebrospinal fluid (CSF) cells collected during laparoscopic fetoscopic repair of spina bifida. This research revealed clonal expansion and activation of fetal T cells as early as the second trimester in utero. Furthermore, we generated the first scRNA-seq data from pediatric RSV + SARS-CoV-2 co-infected subjects, uncovering synergistic and antagonistic innate immune responses. The combination of my training in multiomics, viral pathogenesis, and environmental exposures lend to a promising niche that aligns with the directives of the NICHD, NIAID, NIEHS, and NIMHD. Continued mentorship in maternal-fetal immunology and microbiome research will further enhance my capabilities. I am committed to leveraging Baylor's intellectual resources and Texas Children’s Hospital's facilities to explore genetic, environmental, and microbial molecular mechanisms driving perinatal and pediatric disease states.

Websites

Barrozo Lab

Selected Publications

Barrozo ER, Seferovic MD, Castro ECC, Major AM, Moorshead DN, Jochum MD, Rojas RF, Shope CD, Aagaard KM. " " Med. 2023 Jul 7;
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Barrozo ER, Seferovic MD, Hamilton MP, Moorshead DN, Do T, O’Neil D, Aagaard KM. " " Am J Obstet Gynecol. 2023 Aug 18;
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Barrozo ER, Aagaard KM. " " BJOG. 2021 Oct 15;
Hunter R, Baird B, Garcia M, Begay J, Goitom S, Lucas S, Herbert G, Scieszka D, Padilla J, Brayer K, Ottens AK, Suter MA, Barrozo ER, Hines C, Bleske B, Campen MJ. " " Toxicol Sci. 2023 Sep 11;
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Hessami K, Norooznezhad AH, Monteiro S, Barrozo ER, Abdolmaleki AS, Arian SE, Zargarzadeh N, Shekerdemian LS, Aagaard KM, Shamshirsaz AA.. " " JAMA Netw Open. 2022 Oct 3;
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Hessami K, Aagaard KM, Castro EC, Arian SE, Nassr AA, Barrozo ER, Seferovic MD, Shamshirsaz AA. " " Am J Perinatol. 2022 Nov ;
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Walker K, Kalra D, Lowdon R, Chen G, Molik D, Soto DC, Dabbaghie F, Khleifat AA, Mahmoud M, Paulin LF, Raza MS, Pfeifer SP, Agustinho DP, Aliyev E, Avdeyev P, Barrozo ER, et al., Sedlazeck FJ, Busby B.. " " F1000Res. 2022 May 16;
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Beavis AC, Tran Kim, Barrozo ER, Phan SI, Teng M, He Biao. " " J Virol. 2021 Oct 6;
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Barrozo ER, Nakayama S, Singh P, Neumann D, Bloom DC. " " 2020 ;
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Barrozo ER, Nakayama S, Singh P, Vanni EAH, Arvin AM, Neumann D, Bloom DC. " " 2020 ;
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Phelan D, Barrozo ER, Bloom DC. " " 2017 ;
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Barrozo ER, Fowler DA, Beckman ML. " " 2015 ;
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Garcia MA, Liu R, Nihart A, El Hayek E, Castillo E, Barrozo ER, Suter MA, Bleske B, Scott J, Forsythe K, Gonzalez-Estrella J, Aagaard KM, Campen MJ. " " Toxicol Sci. 2024 ;
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Garcia MA, Liu R, Nihart A, El Hayek E, Castillo E, Barrozo ER, Suter MA, Bleske B, Scott J, Forsythe K, Gonzalez-Estrella J, Aagaard KM, Campen MJ. " " Toxicol Sci. 2024 Feb ;
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Barrozo ER, Racusin DA, Jochum MD, Garcia BT, Suter MA, Delbeccaro M, Shope C, Antony K, Aagaard KM.. " " Am J Obstet Gynecol. 2024 May ;
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Bolte E, Dean T, Garcia B, Seferovic MD, Sauter K, Hummel G, Bucher M, Li F, Hicks J, Qin X, Suter MA, Barrozo ER, Jochum M, Shope C, Friedman JE, Gannon M, Weslowski SR, Mccurdy CE, Kievit P, Aagaard KM. " " Am J Obstet Gynecol. 2024 Jun ;
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Memberships

American Association for the Advancement of Science: Member (07/2015)

American Society for Virology: Member (07/2017)

Edward A. Bouchet Graduate Honor Society: Member (11/2019)

American Society of Gene & Cell Therapy: Associate Member (07/2019)

Society for Maternal-Fetal Medicine: Member (01/2021)

American Society for Microbiology: Member (02/2021)

10x Genomics Clinical Translational Research Network: Member (05/2021)

Society for Reproductive Investigation (SRI): Member (01/2022)

The American Association of Immunologists: Member (06/2023)

The American Society for Reproductive Immunology (ARSI): Member (01/2024)

Perinatal Research Society (PRS): Associate Member (01/2024)

Funding

F31 NIH Predoctoral Fellowship #F31AI140713: (08/08/2019 - 12/31/2020); Grant funding from NIAID

Career Development Award in Immunological Aspects of Gene Therapy and Vaccines: $100,000.00 (01/01/2022 - 01/01/2023); Grant funding from American Society for Gene & Cell Therapy

Molecular Mechanisms of Immune Programming In Utero #2208903: $138,000.00 (06/01/2022 - 02/01/2024); Grant funding from NSF Postdoctoral Research Fellowship in Biology

NIH Loan Repayment Program, Pediatric Research #1L40AI171990-01: $200,000.00 (07/01/2022 - 06/01/2024); Grant funding from NIAID

Maternal and Infant Environmental Health Riskscape (MIEHR) Pilot Award: $50,000.00 (04/01/2023 - 04/01/2024); Grant funding from NIEHS/NIMHD; Disproportionate Bioaccumulation of Microplastics in the Placentae of Vulnerable Populations Correlated with Adverse Obstetrics Outcomes

Impact of Microplastic Accumulation on Preterm Birth Through Placental Inflammatory Pathways #P30ES030285: $40,000.00 (06/20/2024 - 05/31/2025); Grant funding from Gulf Coast Center for Precision Environmental Health (GC-CPEH)

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