Positions
- Assistant Professor
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Medicine - Endocrinology
ÌÇÐÄÊÓƵ of Medicine
Houston, Texas, United States
- Assistant Professor
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Molecular & Cellular Biology
ÌÇÐÄÊÓƵ of Medicine
Houston, Texas, United States
- Member
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Dan L Duncan Comprehensive Cancer Center
ÌÇÐÄÊÓƵ of Medicine
Houston, Texas, United States
- Member
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Texas Medical Center Digestive Diseases Center
ÌÇÐÄÊÓƵ of Medicine
Houston, Texas, United States
Addresses
- Alkek Building for Biomedical Research (Office)
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Room: ABBR-R615
Houston, TX, 77030
United States
dongyin.guan@bcm.edu
Education
- PhD from Case Western Reserve University
- Cleveland
- Postdoctoral Fellowship at University of Pennsylvania
- Philadelphia
Professional Interests
- The impacts of environmental factors and genetic background on physiological rhythms using cutting-edge functional epigenomic approaches.
Professional Statement
Circadian rhythms allow mammals to anticipate daily environmental changes and maintain physiological homeostasis. Circadian misalignment is correlated to many metabolic diseases based on epidemiological studies. For example, night shift workers and individuals with sleep disorders are at increased risk of obesity, diabetes, and related metabolic diseases, similar to the effects of overnutrition. The PI has established a connection between circadian remodeling and metabolic dysfunction associated with fatty liver disease in diet-induced obesity mice (Cell 2018 PMID: 30057115 and Science 2020 PMID: 32732282). The recent research focus in the Guan lab includes investigating the impacts of environmental factors and genetic background on physiological rhythms using cutting-edge functional epigenomic approaches (Nature Communications 2025, Cell Metabolism 2025). The Guan lab is highly collaborative and integrative of unbiased multiple-omics and loss-of-function tools to develop innovative chrono-pharmacological and chrono-nutritive therapeutic strategies relating to metabolic diseases and cancer.
The Guan Lab is looking for talented individuals to join our team. We value dedication, collaboration, a positive attitude, and perseverance. The lab is currently receiving graduate students at BCM for rotation and recruiting postdoctoral researchers and research technicians.
The Guan Lab is looking for talented individuals to join our team. We value dedication, collaboration, a positive attitude, and perseverance. The lab is currently receiving graduate students at BCM for rotation and recruiting postdoctoral researchers and research technicians.
Videos
Selected Publications
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Guan D, Xiong Y, Trinh TM, Xiao Y, Hu W, Jiang C, Dierickx P, Jang C, Rabinowitz JD, Lazar MA.. " " Science. 2020 Sep 11; 369 (6509) : 1388-1394.
Pubmed PMID: . -
Guan D, Xiong Y, Borck PC, Jang C, Doulias PT, Papazyan R, Fang B, Jiang C, Zhang Y, Briggs ER, Hu W, Steger D, Ischiropoulos H, Rabinowitz JD, Lazar MA.. " Diet-Induced Circadian Enhancer Remodeling Synchronizes Opposing Hepatic Lipid Metabolic Processes. " Cell. 2018 Aug 9; 174 (4) : 831-842.
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Guan D, Lazar MA.. " " J Clin Invest. 2021 Aug 2; 131 (5) : e148278.
Pubmed PMID: . -
Zhou D, Chen Y, Liu P, Zhu K, Holder-Haynes J, Lloyd SJ, La CM, Astapova II, Choa S, Xiong Y, Bae H, Aguilar M, Yang H, An YA, Sun Z, Herman MA, Gao X, Pei L, Jang C, Rabinowitz JD, Mattar SG, Zhang Y, Guan D.. " " Cell Metab. 2025 Oct 7; 37 (10) : 1961-1979.
Pubmed PMID: .
Funding
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Recruitment of First-Time, Tenure-Track Faculty Members
- Cancer Prevention and Research Institute of Texas
- CPRIT Scholar
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Mentored Research Scientist Career Development Award (K01)
- NIDDK
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MERIT R37
#CA296577 - (06/01/2025 - 05/31/2030)
- Grant funding from NCI
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