David Lonard

David Lonard, Ph.D.

Professor

Email

dlonard@bcm.edu

Positions

Professor: Mol & Cell Biology-Mol.Regulation
��Ƶ of Medicine
Houston, TX, US

Member: Dan L Duncan Comprehensive Cancer Center
��Ƶ of Medicine
Houston, Texas, United States

Addresses

BCM-Michael DeBakey Center (Office): Room: BCMM-M809
Houston, TX, 77030
United States

BCM-Michael DeBakey Center (Lab): Room: BCMM-M809
Houston, TX, 77030
United States

Education

Advanced Training from ��Ƶ Of Medicine: 01/2002 - Houston, TX, United States

Ph.D. from Texas A&M University: 01/1996 - College Station, TX, United States

B.S. from Texas A&M University: 01/1992 - College Station, TX, United States

Certifications

Associate Professor: ��Ƶ of Medicine

Professional Interests

Research interests

Professional Statement

My laboratory is interested in delineating the molecular mechanisms that link proteasome-mediated protein degradation to nuclear receptor mediated gene expression and coactivator function. As a postdoctoral fellow in Dr. Bert O’Malley’s group, I was able to establish that the ubiquitin-proteasome pathway is required for efficient transcription mediated through the estrogen receptor and other nuclear receptors. These studies established that the proteasome has complex and dynamic effects on the function of steroid receptor coactivator (SRC) family members. My current interests are focused on taking advantage of these basic findings to design high throughput small molecule inhibitors (SMIs) to target these coactivators. Given the pleiotropic roles of SRC family coactivators in cancer, energy metabolism and reproduction, we plan to develop novel coactivator-targeting compounds as therapeutic agents to treat or control these broad pathological and physiological states. Through high throughput screening of small molecule compound libraries, we have identified agents that are able to inhibit SRC function.

Websites

Selected Publications

Li X, Lonard DM, O'Malley BW. " " Mech. Ageing Dev.. ; 125 (41558) : 669-78.
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He B, Feng Q, Mukherjee A, Lonard DM, DeMayo FJ, Katzenellenbogen BS, Lydon JP, O'Malley BW. " " Mol. Endocrinol.. 2008 Feb ; 22 (2) : 344-60.
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Yi P, Feng Q, Amazit L, Lonard DM, Tsai SY, Tsai MJ, O'Malley BW. " " Mol. Cell. 2008 Feb 29; 29 (4) : 465-76.
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Lonard DM, O'Malley BW. " " Prog Mol Biol Transl Sci. 2009 ; 87 : 117-35.
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Yu G, Zhao Y, He J, Lonard DM, Mao CA, Wang G, Li M, Li X. " " J Mol Cell Biol. 2010 Aug ; 2 (4) : 192-8.
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Long W, Foulds CE, Qin J, Liu J, Ding C, Lonard DM, Solis LM, Wistuba II, Qin J, Tsai SY, Tsai MJ, O'Malley BW. " " J. Clin. Invest.. 2012 May 1; 122 (5) : 1869-80.
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Lonard DM, O'Malley BW. " " Trends Biochem. Sci.. 2005 Mar ; 30 (3) : 126-32.
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Lonard DM, O'Malley BW. " " Nature. 2008 Apr 24; 452 (7190) : 946-7.
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Dennis AP, Lonard DM, Nawaz Z, O'Malley BW. " " J. Steroid Biochem. Mol. Biol.. 2005 Mar ; 94 (4) : 337-46.
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Lonard DM, Kumar R, O'Malley BW. " " Mol. Endocrinol.. 2010 Feb ; 24 (2) : 279-85.
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Luo Z, Xu X, Gu P, Lonard D, Gunaratne PH, Cooney AJ, Azencott R. " " PLoS ONE. 2011 ; 6 (10) : e23263.
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Stanisic V, Lonard DM, O'Malley BW. " " Prog. Brain Res.. 2010 ; 181 : 153-76.
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Lonard DM, Smith CL. " " Steroids. 2002 Jan ; 67 (1) : 15-24.
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Han SJ, Lonard DM, O'Malley BW. " " Trends Endocrinol. Metab.. 2009 Jan ; 20 (1) : 41501.
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Lonard DM, Lanz RB, O'Malley BW. " " Endocr. Rev.. 2007 Aug ; 28 (5) : 575-87.
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Lonard DM, O'malley BW. " " Mol. Cell. 2007 Sep 7; 27 (5) : 691-700.
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Lonard DM, O'Malley BW. " " Nat Rev Endocrinol. 2012 Oct ; 8 (10) : 598-604.
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Stanisic V, Malovannaya A, Qin J, Lonard DM, O'Malley BW. " " J. Biol. Chem.. 2009 Jun 12; 284 (24) : 16135-45.
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Geng C, He B, Xu L, Barbieri CE, Eedunuri VK, Chew SA, Zimmermann M, Bond R, Shou J, Li C, Blattner M, Lonard DM, Demichelis F, Coarfa C, Rubin MA, Zhou P, O'Malley BW, Mitsiades N. " " Proc. Natl. Acad. Sci. U.S.A.. 2013 Apr 23; 110 (17) : 6997-7002.
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Nawaz Z, Lonard DM, Dennis AP, Smith CL, O'Malley BW. " " Proc. Natl. Acad. Sci. U.S.A.. 1999 Mar 2; 96 (5) : 1858-62.
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Cavarretta IT, Mukopadhyay R, Lonard DM, Cowsert LM, Bennett CF, O'Malley BW, Smith CL. " " Mol. Endocrinol.. 2002 Feb ; 16 (2) : 253-70.
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Liu J, Yu G, Zhao Y, Zhao D, Wang Y, Wang L, Liu J, Li L, Zeng Y, Dang Y, Wang C, Gao G, Long W, Lonard DM, Qiao S, Tsai MJ, Zhang B, Luo H, Li X. " " J. Cell. Sci.. 2010 Dec 1; 123 : 4076-84.
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Lonard DM, Tsai SY, O'Malley BW. " " Mol. Cell. Biol.. 2004 Jan ; 24 (1) : 14-24.
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Wang Y, Lonard DM, Yu Y, Chow DC, Palzkill TG, O'Malley BW. " " Mol. Endocrinol.. 2011 Dec ; 25 (12) : 2041-53.
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Yan F, Gao X, Lonard DM, Nawaz Z. " " Mol. Endocrinol.. 2003 Jul ; 17 (7) : 1315-31.
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Wu RC, Feng Q, Lonard DM, O'Malley BW. " " Cell. 2007 Jun 15; 129 (6) : 1125-40.
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Yi P, Xia W, Wu RC, Lonard DM, Hung MC, O'Malley BW. " " Genes Dev.. 2013 Feb 1; 27 (3) : 274-87.
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Lonard DM, O'Malley BW. " " 2008 ; 1 (13) : pe16.
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Lonard DM, Nawaz Z, Smith CL, O'Malley BW. " " Mol. Cell. 2000 Jun ; 5 (6) : 939-48.
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Nawaz Z, Lonard DM, Smith CL, Lev-Lehman E, Tsai SY, Tsai MJ, O'Malley BW. " " Mol. Cell. Biol.. 1999 Feb ; 19 (2) : 1182-9.
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Lonard DM, O'Malley BW. " " Cell. 2006 May 5; 125 (3) : 411-4.
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Li X, Lonard DM, Jung SY, Malovannaya A, Feng Q, Qin J, Tsai SY, Tsai MJ, O'Malley BW. " " Cell. 2006 Jan 27; 124 (2) : 381-92.
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Li C, Ao J, Fu J, Lee DF, Xu J, Lonard D, O'Malley BW. " " Oncogene. 2011 Oct 20; 30 (42) : 4350-64.
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Li X, Amazit L, Long W, Lonard DM, Monaco JJ, O'Malley BW. " " Mol. Cell. 2007 Jun 22; 26 (6) : 831-42.
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Funding

Small molecule SRC-2 antagonists as regulators of Sertoli cell function and male fertility #5U01HD076596: $219,100.00 (08/24/2012 - 06/30/2017); Grant funding from NIH; The goal of this study is to identify and develop small molecule antagonist capable of inhibiting SRC-2 for their use as male contraceptive agents

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