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Daniel Calame

Calame

Daniel Calame, M.D., Ph.D.

Instructor

Email

daniel.calame@bcm.edu

Positions

Instructor
Pediatrics
Pediatric Neurology and Developmental Neurosciences
ÌÇÐÄÊÓƵ of Medicine
Houston, TX, US

Honors & Awards

MDA Development Award
Muscular Dystrophy Association
Chao Physician Scientist Award
ÌÇÐÄÊÓƵ of Medicine
CNCDP-K12
NINDS, Kennedy-Krieger Institute
Burroughs Wellcome Fund Career Award for Medical Scientist Finalist

Professional Interests

  • Clinical neurogenetics
  • Neurodevelopmental disorders
  • Hereditary spastic paraplegia
  • Pathogenesis of developmental movement disorders
  • Cerebral palsy
  • Human genetics and genomics

Professional Statement

Despite advances in genome-wide technologies including exome sequencing, short-read whole genome sequencing, and array comparative genomic hybridization, diagnostic genetic testing fails to deliver a definitive diagnosis to most patients with rare neurogenetic diseases including muscular dystrophies, neuropathies, epilepsy, cerebral palsy, and neurodevelopmental disorders. In both my clinical practice and my research in Jim Lupski's lab as part of the ÌÇÐÄÊÓƵ of Medicine Genomics Research Elucidates the Genetics of Rare disease (BCM-GREGoR) program I am fully committed to ‘solving the unsolved’ – to find genetic answers and end the diagnostic odyssey for patients and families with rare diseases. In addition, I am interested in better characterization of the phenotypic spectrum and natural history of rare diseases to improve anticipatory guidance and prognostication and develop clinical trials readiness.

Selected Publications

  • Calame DG, Bakhtiari S, et al.. " " Genet Med. 2021 ; 23(12) (12) : 2455-2460.
    Pubmed PMID: .
  • Calame DG, Herman I, et al. " " Ann Neurol. 2022 ; 92 (2) : 304-321.
    Pubmed PMID: .
  • Daniel G Calame, Tianyu Guo , Chen Wang, et al.. " " Am J Hum Genet. 2023 Aug 3; 110 (8) : 1394-1413.
    Pubmed PMID: .
  • Brown et al.. " " Nature. 2022 ; 605 (7909) : 349-356.
    Pubmed PMID: .

Memberships

Child Neurology Society
American Academy of Neurology
American Academy of Pediatrics
Alpha Omega Alpha

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