Chetan Rajpurohit
Postdoctoral Associate
Positions
- Postdoctoral Associate
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Department of Molecular and Human Genetics
ÌÇÐÄÊÓƵ of Medicine
Houston, Texas, US
Addresses
- One Baylor Plaza (Lab)
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Houston, TX, 77030
United States
Education
- PhD from CSIR-Indian Institute of Toxicology Research
- 10/2019 - Lucknow, Uttar Pradesh, India
- MSc from Dayanand College Ajmer
- 05/2012 - Ajmer, Rajasthan, India
Professional Statement
My research at Hui Zheng Lab focuses on understanding the cellular mechanisms underlying Alzheimer's disease (AD) using transgenic human induced pluripotent stem cell (iPSC)-derived brain cells associated with the disease. Specifically, we have differentiated iPSCs with R406W and P301S mutations in the microtubule-associated protein tau into cortical neurons and astrocytes to study the downstream targets of transcription factor EB (TFEB). TFEB is a master regulator of lysosomal biogenesis and autophagy pathways. My goal is to investigate how TFEB activity manages APP and tau aggregation in iPSC-derived neurons and how it alters their characteristics.
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