ÌÇÐÄÊÓƵ

Email

Positions

Assistant Professor

Molec. Physiology/Hamilton
ÌÇÐÄÊÓƵ of Medicine
Houston, TX, US

Addresses

BCM-MD Anderson Hall (Lab)

Room: BCMA-400B
Houston, TX, 77030
United States

Education

PhD from Korea University

02/2004 - Seoul, South Korea

Professional Interests

• Ca2+ channel-mediated events in skeletal muscle and whole body metabolism

Websites

Selected Publications

• Carlo Manno, Lourdes Figueroa, Leandro Royer, Sandrine Pouvreau, Chang Seok Lee et. al.. " Altered Ca2+ concentration, permeability and buffering in the myofiber Ca2+ store of a mouse model of malignant hyperthermia. " Journal of Physiology. 2013 Sep 15; 591 (18)
• Dimitra K. Georgiou*, Adan Dagnino-Acosta*, Chang Seok Lee*, Deric M. Griffin, Hui Wang, William R. Lagor, Robia G. Pautler, Robert T. Dirksen and Susan L. Hamilton.. " Ca2+ Binding/Permeation via Calcium Channel, CaV1.1, Regulates the Intracellular Distribution of the Fatty Acid Transport Protein, CD36, and Fatty Acid Metabolism. " J. Biol. Chem.. 2015 Aug ;
• Chang Seok Lee1, Adan Dagnino-Acosta1, Viktor Yarotskyy2, Amy Hanna1, Alla Lyfenko2, Mark Knoblauch1, Dimitra K. Georgiou1, Ross A. Poché1, Michael W. Swank1, Cheng Long1, Iskander I. Ismailov1, Johanna Lanner1, Ted Tran1, KeKe Dong et. al.. " Ca2+ Permeation and/or Binding to CaV1.1 Fine-Tunes Skeletal Muscle Ca2+ Signaling to Sustain Muscle Function.. " Skeletal Muscle. 2015 Jan 29; 5 (4)
• Chang Seok Lee1*, Dimitra K.Georgiou1*, Adan Dagnino-Acosta1*, Jianjun Xu1,5, Iskander I. Ismailov1,6, Mark Knoblauch1, Tanner O. Monroe1, RuiRui Ji1, Amy D. Hanna et. al.. " Ligands for FKBP12 Increase Ca2+ Influx and Protein Synthesis to Improve Skeletal Muscle Function. " J. Biol. Chem.. 2014 Sep 12; 289 (37)
• Jae-Sung Yi1, Jun-sub Park1, Young-Mi Ham1, Nga Nguyen1, Na-Rae Lee1, Jin Hong1, Bong-Woo Kim1, Hyun Lee1, Chang-Seok Lee et. al.. " MG53-induced IRS-1 ubiquitination negatively regulates skeletal myogenesis and insulin signaling. " Nature Communications. 2013 Aug 22;
• Johanna T Lanner*, Dimitra K Georgiou*, Adan Dagnino-Acosta, Alina Ainbinder, Qing Cheng, Aditya D Joshi, Zanwen Chen, Viktor Yarotskyy, Joshua M Oakes, Chang Seok Lee et. al.. " AICAR prevents heat-induced sudden death in RyR1 mutant mice independent of AMPK activation. " Nat. Med.. 2012 Feb ; 18 (2)
• Chang Seok Lee1*, Jae-Sung Yi1*, Soon-Young Jung1, Bong-Woo Kim1, Na-Rae Lee1, Hyo-Jung Choo1, Soon-Young Jang1, Jikhyun Han1, Sung-Gil Chi1, Minseon Park2, Jae-Ho Lee2, and Young-Gyu Ko. " TRIM72 negatively regulates myogenesis via targeting insulin receptor substrate-1. " Cell Death Diff.. 2010 Aug ; 17 (8)

Projects

Regulation of Apoptosis by Endoplasmic/Sarcoplasmic Reticulum Ca2+ Stores: Role in Central Core Disease

ÌÇÐÄÊÓƵ of Medicine (01/2012 - present)

Molecular Physiology and Biophysics

Project on going

A novel mechanism of brown adipogenesis through Ca2+ events

ÌÇÐÄÊÓƵ of Medicine (01/2015 - present)

Molecular Physiology and Biophysics

On going Project

Memberships

American Association for the Advancement of Science (AAAS)

Regular Member (08/2015 - 08/2016)

Biophysical Society

Postdoc member (03/2011 - 03/2012)

Skills

Ca2+ signaling pathways

Muscle Fiber typing

Muscle Metabolisms

Brown adipose precursor cell culture