Betty L. Slagle

(713) 798-3006

Email

bslagle@bcm.edu

Professional Interests

Pathogenesis of viral hepatitis

Professional Statement

Chronic infection with hepatitis B virus (HBV) affects approximately 350 million people worldwide and constitutes a significant risk factor for severe liver disease, including hepatocellular carcinoma (HCC). HBx is the sole regulatory protein encoded by HBV. It is required for virus replication, and has a cancer cofactor role in HBx transgenic mice. New plasmid-based HBV replication assays provide an opportunity to evaluate HBx function in the context of virus replication, and in a biologically relevant setting. The long-term goal of our research is to identify the function provided by HBx that is critical for virus replication. The information generated may allow us to identify new cellular targets through which to disrupt chronic virus replication and prevent serious liver pathology and HCC.

Selected Publications

Marriott SJ, Lee TH, Slagle BL, Butel JS. " " Virology. 1996 Oct 1; 224 (1) : 206-13.
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Hsu HC, Peng SY, Lai PL, Sheu JC, Chen DS, Lin LI, Slagle BL, Butel JS. " " Cancer. 1994 Jan 1; 73 (1) : 42-7.
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Madden CR, Finegold MJ, Slagle BL. " " J. Virol.. 2002 Nov ; 76 (22) : 11770-4.
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Nath A, Slagle B, Wolinsky JS. " " Arch. Virol.. 1989 ; 107 (41276) : 159-67.
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Nag A, Datta A, Yoo K, Bhattacharyya D, Chakrabortty A, Wang X, Slagle BL, Costa RH, Raychaudhuri P. " " J. Virol.. 2001 Nov ; 75 (21) : 10383-92.
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Slagle BL, Zhou YZ, Birchmeier W, Scorsone KA. " " Hepatology. 1993 Oct ; 18 (4) : 757-62.
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Sepulveda AR, Finegold MJ, Smith B, Slagle BL, DeMayo JL, Shen RF, Woo SL, Butel JS. " " Cancer Res.. 1989 Nov 1; 49 (21) : 6108-17.
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Wentz MJ, Becker SA, Slagle BL. " " Virus Res.. 2000 Jun ; 68 (1) : 87-92.
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Connolly E, Melegari M, Landgraf P, Tchaikovskaya T, Tennant BC, Slagle BL, Rogler LE, Zavolan M, Tuschl T, Rogler CE. " " Am. J. Pathol.. 2008 Sep ; 173 (3) : 856-64.
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Xu Z, Yen TS, Wu L, Madden CR, Tan W, Slagle BL, Ou JH. " " J. Virol.. 2002 Mar ; 76 (5) : 2579-84.
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Keasler VV, Hodgson AJ, Madden CR, Slagle BL. " " J. Virol.. 2007 Mar ; 81 (6) : 2656-62.
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Madden CR, Finegold MJ, Slagle BL. " " J. Virol.. 2000 Jun ; 74 (11) : 5266-72.
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Slagle BL, Lanford RE, Medina D, Butel JS. " " Cancer Res.. 1984 May ; 44 (5) : 2155-62.
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Slagle BL, Kaufman RH, Reeves WC, Icenogle JP. " " Cancer. 1998 Oct 1; 83 (7) : 1401-8.
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Becker SA, Zhou YZ, Slagle BL. " " Cancer Res.. 1996 Nov 1; 56 (21) : 5092-7.
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Slagle BL, Lee TH, Butel JS. " " Prog. Med. Virol.. 1992 ; 39 : 167-203.
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Keasler VV, Hodgson AJ, Madden CR, Slagle BL. " " Virology. 2009 Jul 20; 390 (1) : 122-9.
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Slagle BL, Zhou YZ, Butel JS. " " Cancer Res.. 1991 Jan 1; 51 (1) : 49-54.
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Hodgson AA, Hyser JM, Keasler VV, Cang Y, Slagle BL. " " Virology. 2012 Apr 25; 426 (1) : 73-82.
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Kumar M, Jung SY, Hodgson AJ, Madden CR, Qin J, Slagle BL. " " J. Virol.. 2011 Jan ; 85 (2) : 987-95.
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Madden CR, Finegold MJ, Slagle BL. " " J. Virol.. 2001 Apr ; 75 (8) : 3851-8.
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Becker SA, Lee TH, Butel JS, Slagle BL. " " J. Virol.. 1998 Jan ; 72 (1) : 266-72.
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Chomarat P, Rice JM, Slagle BL, Wild CP. " " Toxicol. Lett.. 1998 Dec 28; 102 : 595-601.
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Slagle BL, Butel JS. " " Virology. 1985 May ; 143 (1) : 127-42.
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Donehower LA, Slagle BL, Wilde M, Darlington G, Butel JS. " " Nucleic Acids Res.. 1989 Jan 25; 17 (2) : 699-710.
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Keasler VV, Lerat H, Madden CR, Finegold MJ, McGarvey MJ, Mohammed EM, Forbes SJ, Lemon SM, Hadsell DL, Grona SJ, Hollinger FB, Slagle BL. " " Virology. 2006 Apr 10; 347 (2) : 466-75.
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Slagle BL, Lee TH, Medina D, Finegold MJ, Butel JS. " " Mol. Carcinog.. 1996 Apr ; 15 (4) : 261-9.
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Khaoustov VI, Ozer A, Smith JR, Noda A, Mearns M, Krishnan B, Slagle BL, Yoffe B. " " Lab. Invest.. 1995 Jul ; 73 (1) : 118-27.
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Butel JS, Lee TH, Slagle BL. " " Trends Microbiol.. 1996 Mar ; 4 (3) : 119-24.
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Slagle BL, Medina D, Butel JS. " " J. Natl. Cancer Inst.. 1987 Aug ; 79 (2) : 323-35.
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Donehower LA, Harvey M, Slagle BL, McArthur MJ, Montgomery CA, Butel JS, Bradley A. " " Nature. 1992 Mar 19; 356 (6366) : 215-21.
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Slagle BL, Wheeler DA, Hager GL, Medina D, Butel JS. " " Virology. 1985 May ; 143 (1) : 41289.
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Longato L, de la Monte S, Kuzushita N, Horimoto M, Rogers AB, Slagle BL, Wands JR. " " Hepatology. 2009 Jun ; 49 (6) : 1935-43.
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Slagle BL. " " Hepatology. 1995 Feb ; 21 (2) : 597-9.
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Scorsone KA, Zhou YZ, Butel JS, Slagle BL. " " Cancer Res.. 1992 Mar 15; 52 (6) : 1635-8.
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Hodgson AJ, Keasler VV, Slagle BL. " " Cancer Res.. 2008 Dec 15; 68 (24) : 10341-8.
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Madden CR, Slagle BL. " " Dis. Markers. 2001 ; 17 (3) : 153-7.
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Zhou YZ, Slagle BL, Donehower LA, vanTuinen P, Ledbetter DH, Butel JS. " " J. Virol.. 1988 Nov ; 62 (11) : 4224-31.
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Luo N, Cai Y, Zhang J, Tang W, Slagle BL, Wu X, He S. " " Virus Res.. 2012 May ; 165 (2) : 170-8.
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Shiyanov P, Hayes SA, Donepudi M, Nichols AF, Linn S, Slagle BL, Raychaudhuri P. " " Mol. Cell. Biol.. 1999 Jul ; 19 (7) : 4935-43.
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Jaitovich-Groisman I, Benlimame N, Slagle BL, Perez MH, Alpert L, Song DJ, Fotouhi-Ardakani N, Galipeau J, Alaoui-Jamali MA. " " J. Biol. Chem.. 2001 Apr 27; 276 (17) : 14124-32.
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Butel JS, Lee TH, Slagle BL. " " Int. Symp. Princess Takamatsu Cancer Res. Fun. 1995 ; 25 : 185-98.
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Betty Slagle

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Betty L. Slagle

Betty L. Slagle

Email

Professional Interests

Professional Statement

Selected Publications

Skills

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