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Ann Marie Leen

Leen

Ann Marie Leen, Ph.D.

Professor

(832) 824-4690

Positions

Professor
Pediatrics-Hem-Onc and Center for Cell & Gene Therapy
ÌÇÐÄÊÓÆµ of Medicine
Houston, TX, US
Member
Dan L Duncan Comprehensive Cancer Center
ÌÇÐÄÊÓÆµ of Medicine
Houston, Texas, United States

Education

PhD from University Of Birmingham
01/2002 - Birmingham, United Kingdom
PhD from ÌÇÐÄÊÓÆµ Of Medicine
01/2005 - Houston, TX, United States

Professional Interests

  • T cell immunotherapy for viruses and cancer

Professional Statement

Dr. Leen's research interests involve using cytotoxic T cells (CTL) for viral and malignant diseases. Dr. Leen is a co-principal investigator on a clinical trial assessing the safety of adoptively transferred donor-derived virus-specific CTL for the prophylaxis and treatment of adenoviral infections post allogeneic stem cell transplant. She is also developing and optimizing methods for generating tumor-specific CTL directed against the cancer testis antigens SSX2 and SSX4, which are expressed in a variety of tumors including Hodgkin Reed Sternberg cells. Therefore, the development of effective methods to reactivate and expand tumor-specific T cells directed against these antigens will lead to the development of immunotherapy protocols for the treatment of patients with relapsed EBV negative Hodgkin's disease and non-Hodgkin Lymphoma.

Websites

Selected Publications

  • Ildefonso CJ, Kong L, Leen A, Chai SJ, Petrochelli V, Chintagumpala M, Hurwitz MY, Chévez-Barrios P, Hurwitz RL. " " Mol. Ther.. 2010 Oct ; 18 (10) : 1885-90.
    Pubmed PMID: .
  • Vera JF, Brenner LJ, Gerdemann U, Ngo MC, Sili U, Liu H, Wilson J, Dotti G, Heslop HE, Leen AM, Rooney CM. " " J. Immunother.. 2010 Apr ; 33 (3) : 305-15.
    Pubmed PMID: .
  • Leen AM, Bollard CM, Myers GD, Rooney CM. " " Biol. Blood Marrow Transplant.. 2006 Mar ; 12 (3) : 243-51.
    Pubmed PMID: .
  • Leen AM, Rooney CM. " " Br. J. Haematol.. 2005 Jan ; 128 (2) : 135-44.
    Pubmed PMID: .

Memberships

American Society of Gene Therapy
International Society of Cellular Therapy

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