Anil Kumar Panigrahi, Ph.D.
Assistant Professor
Positions
- Assistant Professor
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Molecular & Cellular Biology
ÌÇÐÄÊÓƵ of Medicine
Houston, TX, US
Professional Interests
- Mechanism of enhancer action; Cell-free assays for transcription; Proteomics of transcriptional dynamics
Professional Statement
I recognize the fact that many questions in biology cannot be answered in their strictly cellular or organismal contexts, necessitating development of cell-free (in vitro) approaches. I have been always interested in understanding the intricacies of eukaryotic transcription regulation. I began my doctoral training in India by developing assays for ATP-dependent chromatin remodeling. Here at BCM, I developed cell-free assays to quantify enhancer-promoter communications and consequent transcription activation. I aim to employ these assays to further understand the proteomic dynamics at the enhancer-promoter contacts that result in actual transcriptional potentiation. Additionally, my work has provided evidence that different regions within a gene's coding and regulatory domains physically and dynamically interact during the gene's transcription. I aim to further understand how and why such interactions occur.
Websites
Selected Publications
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Panigrahi A.K., Foulds C.E., Lanz R.B., Hamilton R.A., Yi P., Lonard D.M., Tsai M-J., Tsai S.Y., O’Malley B.W.. " " Molec Cell. 2018 ; 70 : 679-694.e7.
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Bader D., Hartig S., Putluri V., Foley S., Hamilton M., Smith E., Saha P., Panigrahi A., Walker C., Zong L., Martini-Stoica H., Chen R., Rajapakshe K., Coarfa C., Sreekumar A., Mitsiades N., Bankson J., Ittmann M., O'Malley B.W., Putluri N. & McGuire S.. " " Nature Metabolism. 2019 ; 1 : 70-85.
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Panigrahi AK, Zhang N, Mao Q, Pati D. " " Mol. Cell. Biol.. 2011 Nov ; 31 (21) : 4335-47.
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Panigrahi AK, Zhang N, Otta SK, Pati D. " " Biochem. J.. 2012 Mar 15; 442 (3) : 661-70.
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